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Nutritional Intervention

Nutritional Supplements for Knee Surgery Recovery

N/A

Recruiting

Led By Chris McGlory, PhD

Research Sponsored by Dr. Chris McGlory, PhD

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosed anterior cruciate ligament injury requiring reconstruction surgery

Patellar tendon graft or quadriceps tendon graft reconstruction procedure

Must not have

Current use of any form of steroid or within the last 6 months

Any form of cancer currently or in the last 5 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 18 months and 12 weeks (8 weeks post surgery), respectively.

Summary

"This trial aims to investigate whether a combination of essential amino acids and omega-3 fatty acids can help prevent muscle loss and weakness after knee surgery. The study will involve participants taking these supplements before and after

Who is the study for?

This trial is for adults with a diagnosed anterior cruciate ligament injury who are scheduled for reconstruction surgery using patellar or quadriceps tendon grafts in Kingston, ON. It's designed to see if certain nutritional supplements can help prevent muscle loss after knee surgery.

What is being tested?

The study tests whether taking omega-3 fatty acids and essential amino acids can reduce muscle atrophy compared to a control group taking safflower oil and non-essential amino acids. Participants will start the supplements 4 weeks before surgery and continue for 2 weeks after.

What are the potential side effects?

Potential side effects may include digestive discomfort or allergic reactions related to the supplement ingredients like omega-3 fatty acids or amino acids. However, these are generally considered safe.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I need surgery for a torn ACL in my knee.

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I had knee surgery using a patellar or quadriceps tendon graft.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have used steroids in the past 6 months.

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I have had cancer in the past 5 years or have it now.

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I have a bleeding disorder or am on blood-thinning medication.

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My surgery is planned at a location not part of the research center.

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My surgery is scheduled within the next 5 weeks.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 18 months and 12 weeks (8 weeks post surgery), respectively.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~18 months and 12 weeks (8 weeks post surgery), respectively.

This trial's timeline: 3 weeks for screening, Varies for treatment, and 18 months and 12 weeks (8 weeks post surgery), respectively. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Feasibility of Recruitment and Retention

Secondary study objectives

Erythrocyte Phospholipid Composition

Expression of Translational Factors Related to Skeletal Muscle Protein Synthesis

Muscle Cross-Sectional Area

+9 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Nutritional InterventionExperimental Treatment1 Intervention

5 g omega-3 fatty acids (3.75 g eicosapentaenoic acid \[EPA\] + 1.25 g docosahexaenoic acid \[DHA\]) per day for 6 weeks, starting 4 weeks before and continuing 2 weeks after surgery, plus 40 g (2 x 20 g) of EAA per day, starting 1 week before and continuing 2 weeks after surgery.

Group II: Placebo ControlPlacebo Group1 Intervention

5 g safflower oil per day for 6 weeks, starting 4 weeks before and continuing 2 weeks after surgery, plus 40 g (2 x 20 g) of NEAA per day, starting 1 week before and continuing 2 weeks after surgery.

0 / 7Eligibility criteria met