MRI for Lupus

Recruiting in Palo Alto (17 mi)

Overseen by Homa Timlin, MD, MSc, MRCP, CCST

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Johns Hopkins University

Disqualifiers: Pregnancy, Renal dialysis, Renal transplant, others

No Placebo Group

Approved in 2 Jurisdictions

Trial Summary

What is the purpose of this trial?

This study is being done to find out if a non-invasive Magnetic Resonance Imaging (MRI) examination of the kidneys may be helpful for diagnosing lupus nephritis in patients with systemic lupus erythematosus (SLE). Participation involves having a kidney MRI that will take between 30 to 60 minutes. Participants may have 1-4 kidney MRIs over a 6-month time period.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Kidney MRI, Magnetic Resonance Imaging of the Kidneys, Renal MRI for lupus?

Research shows that advanced MRI techniques, like BOLD MRI, can help detect kidney issues in lupus patients without invasive procedures. These imaging methods are promising for diagnosing and monitoring kidney health in lupus nephritis, potentially leading to better treatment strategies. ^{1 2 3 4 5}

Is MRI safe for use in humans, particularly for kidney-related conditions?

MRI, including kidney MRI, is generally considered safe for humans as it is a noninvasive imaging technique used to diagnose and monitor various kidney conditions, including lupus nephritis and chronic kidney disease. ^{1 3 5 6 7}

How is the Kidney MRI treatment different from other treatments for lupus nephritis?

Kidney MRI is unique because it uses advanced imaging techniques to assess kidney damage in lupus nephritis without invasive procedures like biopsies. It provides detailed information on kidney function and disease progression, which can help in early diagnosis and better management of the condition. ^{1 2 4 5 8}

Research Team

Homa Timlin, MD, MSc, MRCP, CCST

Principal Investigator

Johns Hopkins School of Medicine

Eligibility Criteria

This trial is for individuals with systemic lupus erythematosus (SLE) who may have kidney inflammation known as lupus nephritis. Details on specific inclusion and exclusion criteria are not provided, but typically participants would need to meet certain health standards.

Inclusion Criteria

I am over 18, diagnosed with SLE, and can have a kidney MRI.

Exclusion Criteria

I have had a kidney transplant.

I am currently on kidney dialysis.

I do not have any conditions or devices that prevent me from having an MRI.

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

MRI Assessment

Participants undergo 1-4 kidney MRIs to evaluate inflammation, fibrosis, and atrophy

6 months

1-4 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after MRI assessments

4 weeks

Treatment Details

Interventions

• Kidney MRI (Procedure)

Trial Overview The study is testing the use of non-invasive kidney MRI scans to diagnose lupus nephritis in SLE patients. Participants will undergo one or more MRI scans over six months to assess this diagnostic method.

Participant Groups

Group I: MRI Experimental Treatment 1 Intervention

A participant will undergo a MRI (1-4).

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Johns Hopkins University School of Medicine Baltimore, MD

Who Is Running the Clinical Trial?

Johns Hopkins University

Lead Sponsor

Trials

2366

Patients Recruited

15,160,000+

Janssen Scientific Affairs, LLC

Industry Sponsor

Trials

165

Patients Recruited

579,000+

Findings from Research

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Blood oxygen level dependent magnetic resonance imaging for detecting pathological patterns in lupus nephritis patients: a preliminary study using a decision tree model. Shi, H., Jia, J., Li, D., et al.[2018]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Tomoelastography Paired With T2* Magnetic Resonance Imaging Detects Lupus Nephritis With Normal Renal Function. Marticorena Garcia, SR., Grossmann, M., Bruns, A., et al.[2019]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study. de Boer, A., Harteveld, AA., Stemkens, B., et al.[2021]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Clinical study on the use of advanced magnetic resonance imaging in lupus nephritis. Chen, YX., Zhou, W., Ye, YQ., et al.[2022]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Research progress in functional magnetic resonance imaging assessment of lupus nephritis kidney injury. Liu, S., Zhou, W.[2023]

In a study of 122 participants with chronic kidney disease (CKD), baseline apparent diffusion coefficient (ADC) values from kidney MRI were associated with changes in kidney function over time, indicating potential for MRI to help identify patients at risk for CKD progression.

However, this association was influenced by albuminuria, and overall, kidney MRI biomarkers remained stable over a 12-month period, suggesting they may not change significantly in the short term.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Kidney Functional Magnetic Resonance Imaging and Change in eGFR in Individuals with CKD. Srivastava, A., Cai, X., Lee, J., et al.[2023]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effect of MR angiography on the diagnosis and treatment of patients with suspected renovascular disease. Omary, RA., Henseler, KP., Salem, R., et al.[2019]

In a pilot study involving 21 participants (6 with lupus nephritis, 8 with lupus non-nephritis, and 7 healthy volunteers), non-contrast MRI biomarkers showed significant correlations with standard renal function measurements, indicating their potential as reliable indicators of disease activity in lupus.

The study found that delayed blood flow and microstructural disruption in the kidneys of lupus nephritis patients were detectable through MRI, suggesting these imaging techniques could help assess kidney health without invasive procedures.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Evaluation of non-contrast MRI biomarkers in lupus nephritis. Skeoch, S., Hubbard Cristinacce, PL., Dobbs, M., et al.[2022]

References

1. England pubmed.ncbi.nlm.nih.gov

Blood oxygen level dependent magnetic resonance imaging for detecting pathological patterns in lupus nephritis patients: a preliminary study using a decision tree model. [2018]

2. United States pubmed.ncbi.nlm.nih.gov

Tomoelastography Paired With T2* Magnetic Resonance Imaging Detects Lupus Nephritis With Normal Renal Function. [2019]

3. United States pubmed.ncbi.nlm.nih.gov

Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study. [2021]

4. England pubmed.ncbi.nlm.nih.gov

Clinical study on the use of advanced magnetic resonance imaging in lupus nephritis. [2022]

5. England pubmed.ncbi.nlm.nih.gov

Research progress in functional magnetic resonance imaging assessment of lupus nephritis kidney injury. [2023]

6. United States pubmed.ncbi.nlm.nih.gov

Kidney Functional Magnetic Resonance Imaging and Change in eGFR in Individuals with CKD. [2023]

7. United States pubmed.ncbi.nlm.nih.gov

Effect of MR angiography on the diagnosis and treatment of patients with suspected renovascular disease. [2019]

8. Italy pubmed.ncbi.nlm.nih.gov

Evaluation of non-contrast MRI biomarkers in lupus nephritis. [2022]