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Exercise for Neuropathic Pain from Chemotherapy
N/A
Waitlist Available
Led By Alice Ryan, PhD
Research Sponsored by Baltimore VA Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Diagnosis with cancer, stage I-IV
History of treatment with oxaliplatin, docetaxel, or paclitaxel, either alone or in combination with other agents
Must not have
Coronary artery disease
History of >1 chemotherapy regimen
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 13 weeks
Awards & highlights
No Placebo-Only Group
Summary
This trial will investigate whether exercise can help relieve neuropathic pain caused by chemotherapy.
Who is the study for?
This trial is for cancer survivors aged 21-70 who finished chemotherapy between 6 months and a year ago, can walk on a treadmill, and have neuropathic pain from the treatment. They must not be regular exercisers or have other types of neuropathy.
What is being tested?
The study looks at how aerobic exercise and resistive training might reduce nerve pain caused by chemotherapy. Participants will either join an exercise program or be in a control group to compare outcomes.
What are the potential side effects?
While specific side effects are not listed for exercising, potential risks may include muscle soreness, fatigue, or injury related to physical activity.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My cancer is between stage I and IV.
Select...
I have been treated with oxaliplatin, docetaxel, or paclitaxel.
Select...
I experience mild to severe chemotherapy-induced nerve pain.
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I can walk on a treadmill.
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I am between 21 and 70 years old.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I have been diagnosed with coronary artery disease.
Select...
I have undergone more than one chemotherapy treatment.
Select...
I do not have any physical conditions that stop me from exercising.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 13 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~13 weeks
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Sensory pain
Secondary study objectives
Nerve fiber density
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
3Treatment groups
Experimental Treatment
Group I: resistive trainingExperimental Treatment1 Intervention
Intervention is for 12 weeks 3 times weekly with training on site.
Group II: controlExperimental Treatment1 Intervention
This is an attention control group with regular contact by study staff.
Group III: aerobic exerciseExperimental Treatment1 Intervention
Aerobic exercise intervention is for 12 weeks 3 times weekly with training on site.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
resistive training
2006
Completed Phase 2
~40
Find a Location
Who is running the clinical trial?
Baltimore VA Medical CenterLead Sponsor
32 Previous Clinical Trials
3,035 Total Patients Enrolled
Alice Ryan, PhDPrincipal InvestigatorUniversity of Maryland at Baltimore School of Medicine