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Electrolyte Solution

Saline Infusion for POTS

N/A
Waitlist Available
Led By Satish R Raj, MD MSCI
Research Sponsored by Vanderbilt University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Hypertension (BP>145/95 or need for anti-hypertensive medications)
Overt or acute cause for orthostatic tachycardia
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial will test whether people with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI/POTS) have difficulty conserving sodium, compared to healthy control subjects.

Who is the study for?
This trial is for individuals diagnosed with orthostatic intolerance or POTS by the Vanderbilt Autonomic Dysfunction Center, as well as healthy controls. It's not suitable for those with an obvious or sudden cause of rapid heartbeat, high blood pressure (over 145/95 or on medication), abnormal EKG results, or if pregnant.
What is being tested?
The study aims to see if patients with chronic orthostatic intolerance or POTS have trouble conserving sodium in their urine compared to healthy people. Participants will receive normal saline (0.9%) during the trial.
What are the potential side effects?
Receiving normal saline is generally safe but can sometimes cause mild side effects like a cool feeling at the injection site, a salty taste in the mouth, or rarely more serious reactions.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have high blood pressure or am on medication for it.
Select...
I experience a rapid heartbeat when standing up.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: 1Experimental Treatment1 Intervention
saline infusion for sodium loading

Find a Location

Who is running the clinical trial?

Vanderbilt UniversityLead Sponsor
710 Previous Clinical Trials
6,143,349 Total Patients Enrolled
13 Trials studying Postural Orthostatic Tachycardia Syndrome
752 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
National Center for Research Resources (NCRR)NIH
539 Previous Clinical Trials
317,072 Total Patients Enrolled
2 Trials studying Postural Orthostatic Tachycardia Syndrome
200 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,931 Previous Clinical Trials
47,766,678 Total Patients Enrolled
12 Trials studying Postural Orthostatic Tachycardia Syndrome
930 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome

Media Library

Normal Saline (Electrolyte Solution) Clinical Trial Eligibility Overview. Trial Name: NCT00581633 — N/A
Postural Orthostatic Tachycardia Syndrome Research Study Groups: 1
Postural Orthostatic Tachycardia Syndrome Clinical Trial 2023: Normal Saline Highlights & Side Effects. Trial Name: NCT00581633 — N/A
Normal Saline (Electrolyte Solution) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00581633 — N/A
~4 spots leftby Dec 2027
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