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Vitamin Supplement

Vitamin K for Knee Osteoarthritis

Phase 1 & 2
Waitlist Available
Led By Jean Liew, MD MS
Research Sponsored by Boston University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Clinical diagnosis of knee OA by the treating rheumatologist
≥60 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 weeks

Summary

This trial aims to test different types and doses of vitamin K supplements in older adults with knee osteoarthritis. The goal is to determine if vitamin K can improve outcomes related to knee osteoar

Who is the study for?
This trial is for older adults who have knee osteoarthritis. It's designed to see if different types and doses of vitamin K can help with the condition. To join, participants must meet certain health criteria that aren't specified here.
What is being tested?
The study tests two forms of vitamin K (K1 at 1000 µg or 500 µg daily, and K2 as MK-7 at 360 µg daily) against a placebo to find out which one might improve knee OA outcomes. Participants will be randomly assigned to receive one of these options.
What are the potential side effects?
While specific side effects are not listed, typical reactions to supplements like vitamin K could include changes in blood clotting ability, allergic reactions, or gastrointestinal discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My rheumatologist diagnosed me with knee osteoarthritis.
Select...
I am 60 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in menaquinone-7 (MK-7) levels
Change in phylloquinone levels
Change in uncarboxylated matrix Gla protein (ucMGP) levels
+1 more
Secondary study objectives
Participant acceptability of intervention
Study adherence

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Vitamin K2 (MK-7) 300 µgExperimental Treatment1 Intervention
Participants randomized to this arm will take one Vitamin K2 (MK-7) 300 µg pill daily for 4 weeks.
Group II: Vitamin K1 500 µgExperimental Treatment1 Intervention
Participants randomized to this arm will take one Vitamin K1 500 µg pill daily for 4 weeks.
Group III: Vitamin K1 1000 µgExperimental Treatment1 Intervention
Participants randomized to this arm will take one Vitamin K1 1000 µg pill daily for 4 weeks.
Group IV: PlaceboPlacebo Group1 Intervention
Participants randomized to this arm will take 1 placebo pill daily for 4 weeks.

Find a Location

Who is running the clinical trial?

Boston UniversityLead Sponsor
472 Previous Clinical Trials
9,987,771 Total Patients Enrolled
12 Trials studying Osteoarthritis
5,951 Patients Enrolled for Osteoarthritis
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)NIH
496 Previous Clinical Trials
1,089,457 Total Patients Enrolled
51 Trials studying Osteoarthritis
46,981 Patients Enrolled for Osteoarthritis
Jean Liew, MD MSPrincipal InvestigatorBoston University Chobanian & Avedisian School of Medicine, Department of Rheumatology
~37 spots leftby Dec 2026
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