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Cognitive Training for Parkinson's Disease

N/A
Waitlist Available
Led By Sule Tinaz, MD, PhD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age ≥ 40 years
Diagnosis of idiopathic PD
Must not have
Hoehn & Yahr stage > 3 (i.e., able to stand and walk, but not fully independent)
History of head injury with loss of consciousness longer than a few minutes
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at baseline, 6 weeks, and 12 weeks.
Awards & highlights
No Placebo-Only Group

Summary

This trialwill explore if cognitive training can help people with PD better manage daily tasks by testing their brain & cognitive skills.

Who is the study for?
This trial is for people over 40 with Parkinson's Disease who are on stable medication. Participants must speak English, not be pregnant or breastfeeding, have no excessive alcohol use, and no metal implants that affect MRI scans. They should be able to lie flat for an hour and not have severe cognitive impairments or other neurological disorders.
What is being tested?
The study tests if mental imagery training and psychoeducation can improve thinking skills and brain function in daily activities for those with Parkinson's. It involves cognitive assessments and MRIs to measure the effects of the interventions.
What are the potential side effects?
Since this trial focuses on non-invasive cognitive training rather than medication, traditional side effects like nausea or headaches aren't expected. However, participants may experience fatigue or discomfort from long periods of concentration or lying still during MRI scans.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 40 years old or older.
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I have been diagnosed with Parkinson's disease.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My Parkinson's disease is advanced; I can stand and walk but need help.
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I've had a head injury that made me unconscious for more than a few minutes.
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I have specific symptoms suggesting a brain disorder not related to Parkinson's.
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I cannot lie flat for an hour.
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I have a history of a serious brain or nerve condition.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at baseline, 6 weeks, and 12 weeks.
This trial's timeline: 3 weeks for screening, Varies for treatment, and at baseline, 6 weeks, and 12 weeks. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Quality of life in Neurological Disorders (Neuro-QoL) Version 2 Cognitive Function scores
Brain
Secondary study objectives
Change in composite executive function test scores
Change in local and global functional connectivity-based graph measures

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Mental ImageryExperimental Treatment1 Intervention
Group II: PsychoeducationActive Control1 Intervention

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,922 Previous Clinical Trials
3,031,511 Total Patients Enrolled
National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,377 Previous Clinical Trials
651,806 Total Patients Enrolled
Sule Tinaz, MD, PhDPrincipal InvestigatorYale University
~1 spots leftby Jan 2025
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