Exercise for Prostate Cancer

N/A

Recruiting

Led By Dong-Woo Kang, PhD

Research Sponsored by Dana-Farber Cancer Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline (week 1) and post-intervention (week 18)

Awards & highlights

No Placebo-Only Group

Summary

This trial will assess if exercise can slow prostate cancer progression in Black men on active surveillance.

Who is the study for?

This trial is for Black men over 18 with early-stage prostate cancer who are on active surveillance. They should be able to visit Dana-Farber Cancer Institute, understand English, sign consent forms, and have medical clearance to exercise. They must do less than 60 minutes of moderate-to-vigorous exercise weekly and not plan any invasive treatments for the next 16 weeks.

What is being tested?

The REMOVE Trial tests if a home-based, virtual high-intensity interval training (HIIT) program can slow prostate cancer progression in participants. It's a supervised 16-week aerobic exercise regimen designed specifically for this study.

What are the potential side effects?

While specific side effects aren't listed for this type of non-drug intervention, general risks may include muscle soreness, fatigue or injury from physical activity. Participants will be monitored for any adverse reactions related to the exercise program.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline (week 1) and post-intervention (week 18)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline (week 1) and post-intervention (week 18)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (week 1) and post-intervention (week 18) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Prostate-Specific Antigen (PSA) Level

Secondary study objectives

Cardiorespiratory Fitness

Fear of Cancer Progression Assessment

Health-Related Quality of Life

+6 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Group B: 16-Week Usual CareExperimental Treatment1 Intervention

Participants will be allocated in a 1:1 ratio, using a permuted blocked design with varying block size. Study procedures will be conducted as follows: * Testing visits at Week 1 and 18 for physical exams, physical fitness and function assessments, and survey questionnaires. * Upon completion of post-intervention assessments, participants will have the option to take part in the 16-week HIIT exercise program.

Group II: Group A: 16-Week HIIT Exercise ProgramExperimental Treatment1 Intervention

Participants will be allocated in a 1:1 ratio, using a permuted blocked design with varying block size. Study procedures will be conducted as follows: * Testing visits at Week 1, 9, and 19 for physical exams, physical fitness and function assessments, survey questionnaires, and cardiopulmonary fitness assessment. * Virtual, aerobic training sessions three times weekly with trained oncology exercise specialist.

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