Extended Mesenteric Excision for Crohn's Disease

Recruiting in Palo Alto (17 mi)

+1 other location

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Montreal General Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?

The study is looking at the role of the mesentery in disease recurrence for ileocolic Crohn's disease. It is a prospective study that has been designed to perform extended mesenteric excision on patients undergoing their first ileocolic resection for Crohn's disease. Endoscopic recurrence will be monitored with the hypothesis that patients receiving extended mesenteric ileocolic resection will have reduced endoscopic recurrence at 6 months after resection.

Research Team

Eligibility Criteria

This trial is for adults over 18 with Crohn's Disease affecting the distal ileum/ileocolic region, who haven't had previous ileocolic resections. It includes all forms of Crohn's presentations like stricturing and fistulizing. Those with prior surgeries in the area or disease in other sites, as well as those with intraabdominal sepsis, cannot participate.

Inclusion Criteria

I am over 18 years old.

I have not had surgery to remove part of my small and large intestine.

My Crohn's disease comes in various forms, including stricturing and fistulizing.

See 1 more

Exclusion Criteria

I have had surgery to remove part of my small and large intestine.

I have Crohn's disease in parts of my body other than the intestines.

I have an infection in my abdomen.

Treatment Details

Interventions

Extended Mesenteric Resection (Procedure)

Trial OverviewThe study tests if removing more of the mesentery (the tissue that attaches intestines to the back wall of the abdomen) during first-time surgery can reduce disease recurrence at six months post-surgery in patients with Crohn's Disease.

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: Intervention ArmExperimental Treatment1 Intervention

Prospective study arm involving an extended mesenteric ileocolic excision.

Group II: Control ArmActive Control1 Intervention

Historical controls from a retrospective chart review of patients who had a limited ileocolic resection.