Neural Stimulation for Schizophrenia

N/A

Waitlist Available

Research Sponsored by The University of Texas at Dallas

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change in daily expectations of social interactions will be assessed from the pre-stimulation ema period (7 days before the stimulation visit) to the post-stimulation ema period (7 days after the stimulation visit)

Summary

This trial will assess whether stimulating the brain can improve symptoms & functioning in people with schizophrenia-like disorders.

Who is the study for?

This trial is for adults aged 18-60 with schizophrenia or schizoaffective disorder experiencing recent paranoia. It's not suitable for pregnant individuals, those with certain developmental disorders, neurological conditions like epilepsy, active substance use disorders, severe sensory impairments, a history of electroconvulsive therapy, non-English speakers, or anyone with implanted medical devices.

What is being tested?

The study investigates if brain stimulation through transcranial Direct Current Stimulation (tDCS) can alleviate psychotic symptoms and improve social functioning in people with schizophrenia spectrum disorders.

What are the potential side effects?

Potential side effects of tDCS may include discomfort at the electrode site on the scalp, itching or tingling during stimulation, fatigue after treatment sessions, headache or nausea.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change in daily paranoia feelings will be assessed from the pre-stimulation ema period (7 days before the stimulation visit) to the post-stimulation ema period (7 days after the stimulation visit)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change in daily paranoia feelings will be assessed from the pre-stimulation ema period (7 days before the stimulation visit) to the post-stimulation ema period (7 days after the stimulation visit)

This trial's timeline: 3 weeks for screening, Varies for treatment, and change in daily paranoia feelings will be assessed from the pre-stimulation ema period (7 days before the stimulation visit) to the post-stimulation ema period (7 days after the stimulation visit) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Paranoid Ideation for Active vs. Sham Stimulation

Social functioning for Active vs. Sham Stimulation

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Active anodal tDCS first, then Sham tDCSExperimental Treatment1 Intervention

Active anodal tDCS (40 minutes; divided into two 20-minutes sessions) followed by behavioral testing; Washout (about 1 week); sham stimulation (40 minutes; divided into two 20-minutes sessions) followed by behavioral testing.

Group II: Sham tDCS first, then Active anodal tDCSPlacebo Group1 Intervention

Sham tDCS (40 minutes; divided into two 20-minutes sessions) followed by behavioral testing; Washout (about 1 week); Active anodal tDCS (40 minutes; divided into two 20-minutes sessions) followed by behavioral testing Intervention.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

tDCS

2017

Completed Phase 2

~630

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