← Back to Search

Transcranial Magnetic Stimulation

TMS for Stroke Rehabilitation

N/A
Waitlist Available
Led By Julianne Freeman, BS
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No history of seizures or epilepsy
Single ischemic infarction affecting the primary motor system
Timeline
Screening 3 weeks
Treatment Varies
Follow Up before, 0 mins after, 30 mins after and 60 mins after motor training.

Summary

This trial will test if a type of brain stimulation can help improve motor skills.

Who is the study for?
This trial is for stroke survivors aged 30-80, with a single ischemic infarction impacting the motor system. Participants must be able to consent, have no cognitive impairments or depression, and not suffer from other neurological diseases. They can't have contraindications to TMS like epilepsy, metal in the head/neck, implanted devices, history of migraines or take seizure-lowering meds.
What is being tested?
The study tests if repetitive transcranial magnetic stimulation (rTMS) on different parts of the brain improves motor function after a stroke. It involves various rTMS techniques over specific brain areas and sham treatments for comparison.
What are the potential side effects?
Possible side effects include discomfort at the stimulation site, headache, lightheadedness, twitching facial muscles during treatment sessions and in rare cases seizures may occur.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have never had seizures or epilepsy.
Select...
I had a stroke that affected my movement control.
Select...
My thinking and memory skills are functioning well.
Select...
I do not have any neurological diseases.
Select...
I have never had a migraine headache.
Select...
I am between 30 and 80 years old.
Select...
I am not taking any medication that increases my risk of seizures.
Select...
I am not currently experiencing depression.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before, 0 mins after, 30 mins after, and 60 mins after motor training.
This trial's timeline: 3 weeks for screening, Varies for treatment, and before, 0 mins after, 30 mins after, and 60 mins after motor training. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Stimulus Response Curve parameters
Change in wrist velocity
Secondary study objectives
Change in Resting Motor Threshold
Change in Short interval intracortical inhibition (SICI) of the primary motor cortex
Change in reaction time
+2 more

Trial Design

5Treatment groups
Experimental Treatment
Placebo Group
Group I: Single TMS over extensor carpi ulnaris spot of motor cortexExperimental Treatment1 Intervention
Location of single-pulse Transcranial Magnetic Stimulation (sTMS): extensor carpi ulnaris (ECU) hotspot of primary motor cortex (M1).
Group II: Repetitive TMS over ipsilateral premotor cortexExperimental Treatment1 Intervention
Location of repetitive Transcranial Magnetic Stimulation (rTMS): ipsilateral premotor cortex.
Group III: Repetitive TMS over contralateral primary motor cortexExperimental Treatment1 Intervention
Location of repetitive Transcranial Magnetic Stimulation (rTMS): contralateral primary motor cortex.
Group IV: Repetitive TMS over contralateral premotor cortexExperimental Treatment1 Intervention
Location of repetitive Transcranial Magnetic Stimulation (rTMS): contralateral premotor cortex.
Group V: Sham repetitive TMS over contralateral premotor cortexPlacebo Group1 Intervention
Location of Sham repetitive Transcranial Magnetic Stimulation (rTMS): contralateral premotor cortex.

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor
1,697 Previous Clinical Trials
2,603,848 Total Patients Enrolled
31 Trials studying Stroke
350,177 Patients Enrolled for Stroke
American Heart AssociationOTHER
346 Previous Clinical Trials
4,971,463 Total Patients Enrolled
42 Trials studying Stroke
3,926,973 Patients Enrolled for Stroke
Julianne Freeman, BSPrincipal InvestigatorEmory University

Media Library

Repetitive TMS over contralateral premotor cortex (Transcranial Magnetic Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT03268070 — N/A
Stroke Research Study Groups: Sham repetitive TMS over contralateral premotor cortex, Single TMS over extensor carpi ulnaris spot of motor cortex, Repetitive TMS over contralateral premotor cortex, Repetitive TMS over ipsilateral premotor cortex, Repetitive TMS over contralateral primary motor cortex
Stroke Clinical Trial 2023: Repetitive TMS over contralateral premotor cortex Highlights & Side Effects. Trial Name: NCT03268070 — N/A
Repetitive TMS over contralateral premotor cortex (Transcranial Magnetic Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03268070 — N/A
~12 spots leftby Feb 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top