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Controlled Breathing for POTS

N/A

Recruiting

Led By Satish R Raj, MD, MSCI

Research Sponsored by University of Calgary

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18-60 years

Physician diagnosis of Postural Tachycardia Syndrome (POTS)

Must not have

Subjects who require portable oxygen at rest or with exercise

Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath

Timeline

Screening 3 weeks

Treatment Varies

Follow Up difference between hr from supine to peak hr during tilt test for each intervention (mean value hr between the 8th and 9th minute of supine; peak parameters, during hutt, mean value during the first min and between the 3rd and 8th min)

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether CO2 can help people with POTS by lowering heart rate and reducing symptoms when upright/standing.

Who is the study for?

This trial is for adults aged 18-60 with a physician's diagnosis of Postural Tachycardia Syndrome (POTS) who can visit the University of Calgary and are non-smokers. Pregnant individuals, those needing portable oxygen, or with severe heart/lung disease, anxiety disorders, or poor past study compliance cannot participate.

What is being tested?

The study tests if controlled breathing using the RespirAct™ system to increase CO2 levels can reduce rapid heartbeat and improve symptoms in POTS patients when standing. The goal is to find the best CO2 level for symptom relief.

What are the potential side effects?

Potential side effects may include discomfort from wearing a mask during the study and possible dizziness or shortness of breath due to changes in CO2 levels while using the RespirAct™ system.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 60 years old.

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I have been diagnosed with POTS by a doctor.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I need portable oxygen for breathing, either at rest or during physical activity.

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I cannot climb stairs without feeling short of breath due to heart or lung problems.

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I have a rapid heartbeat when standing up due to severe dehydration.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ difference between hr from supine to peak hr during tilt test for each intervention (mean value hr between the 8th and 9th minute of supine; peak parameters, during hutt, mean value during the first min and between the 3rd and 8th min)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~difference between hr from supine to peak hr during tilt test for each intervention (mean value hr between the 8th and 9th minute of supine; peak parameters, during hutt, mean value during the first min and between the 3rd and 8th min)

This trial's timeline: 3 weeks for screening, Varies for treatment, and difference between hr from supine to peak hr during tilt test for each intervention (mean value hr between the 8th and 9th minute of supine; peak parameters, during hutt, mean value during the first min and between the 3rd and 8th min) for reporting.