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Transvaginal probe (Photoacoustic + ultrasound imaging) for Cervical Cancer

N/A

Waitlist Available

Led By Perry W Grigsby, M.D.

Research Sponsored by Washington University School of Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months after completion of standard of care treatment (approximately 18 weeks)

Awards & highlights

No Placebo-Only Group

Summary

The investigators have developed co-registered transvaginal photoacoustic and ultrasound (US) imaging techniques that allow them to visualize ovarian tumor structure and functional changes simultaneously, which may potentially reveal early tumor angiogenesis development or residual tumors after systemic treatment that is not available by US alone. The ability to detect early angiogenesis changes, as well as tumor morphology changes using a non-invasive imaging modality will greatly enhance the care for patients. The investigators plan to explore these techniques in monitoring cervical cancer treatment response and conduct pilot feasibility studies.

Eligible Conditions

Cervical Cancer

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months after completion of standard of care treatment (approximately 18 weeks)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months after completion of standard of care treatment (approximately 18 weeks)

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months after completion of standard of care treatment (approximately 18 weeks) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Secondary study objectives

Charge pattern of blood oxygen saturation

Reduction rate of tumor angiogenesis

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Transvaginal probe (Photoacoustic + ultrasound imaging)Experimental Treatment1 Intervention

* A transvaginal imaging probe using ultrasound and photoacoustic imaging will be inserted into the vagina and will use different frequencies of lights to create images * This will occur before the first standard of care treatment, mid-treatment, end of treatment, and approximately 3 months after the end of treatment for a total of 4 imaging time points

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