Procedure
HIFEM and Radiofrequency for Muscle Weakness
Recruiting0 awards2 criteria
Greenwood Village, Colorado
This trial aims to study the impact of the BTL-899M device on muscle function in adults with lower extremity issues. They want to see if this device is effective in improving muscle function compared
Control Group for Blood dyscrasia
Recruiting1 award2 criteria
Aurora, Colorado
Combat and civilian trauma frequently result in open wounds that are at risk for infection. Data from the Department of Defense Trauma Registry demonstrate that 74% of combat trauma casualties have an open wound. The Committee on Tactical Combat Casualty Care, the Prolonged Field Care Working Group, and the Joint Trauma System clinical practice guidelines recommend antibiotic prophylaxis for open wounds after trauma. The civilian setting has similar risks of open wound infection after trauma. In parallel, current practice guidelines recommend the aggressive use of balanced blood products during resuscitation. It remains unclear how the replacement of blood after hemorrhage through transfusion may affect antibiotic concentrations. Data is necessary to better understand this relationship to enhance wound prophylaxis antibiotic dosing, particularly in severely wounded casualties who receive blood products during massive transfusions. It remains unclear how these resuscitation methods may alter pharmacokinetics. The investigators hypothesize that drug concentrations decrease in direct relation to the amount of blood transfused during low-volume, massive, and supermassive transfusion after trauma compared to patients who receive no blood products. The investigators seek to understand the relationship between drug concentrations and blood product administration using a non-compartmentalized model in the setting of hemorrhage. Specifically, they will (1) obtain drug concentrations at regular intervals during the first 12-18 hours after administration of antibiotics, (2) determine how much blood products and fluids are transfused during the 12 hours prior to antibiotic and 24 hours post-administration, and (3) perform data modeling to understand the relationship between blood transfusions and drug concentrations to inform data-driven dosing models. Liquid chromatography methods will be developed to measure drug concentrations. The investigators will conduct a prospective, multicenter study at two large trauma centers - Brooke Army Medical Center and the University of Colorado Hospital. They will seek to enroll any participant who is hospitalized or anticipated hospital admission for acute trauma and receives an antibiotic on the study list during their index hospitalization. They will then model the drug levels against the amount of blood and fluid infused to create an understanding of the pharmacokinetics of antibiotic wound prophylaxis.
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Phase 3 Trials
Aviptidil + SOC for Coronavirus
Recruiting1 awardPhase 3
Aurora, Colorado
This study looks at the safety and effectiveness of Aviptidil in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with Aviptidil plus current standard of care (SOC), or with placebo plus current SOC.
Remdesivir + SOC for Coronavirus
Recruiting1 awardPhase 3
Aurora, Colorado
This study looks at the safety and effectiveness of Remdesivir in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with Remdesivir plus current standard of care (SOC), or with placebo plus current SOC.
Antipsychotic
Lumateperone for Irritability in Autism
Recruiting1 awardPhase 3
Colorado Springs, Colorado
This trial will involve children between 5 and 17 years old with irritability associated with Autism Spectrum Disorder (ASD). The study will be conducted at multiple centers and will compare the effectiveness of a
Trials With No Placebo
Behavioural Intervention
Spinal Stimulation for Spinal Cord Injury
Recruiting1 award5 criteria
Englewood, Colorado
This trial aims to test the safety and effectiveness of using spinal stimulation at home to improve arm and hand function in people with upper extremity impairments. Participants will either receive the stimulation alongside a home exercise
Device
Fetal Monitoring Device for Pregnancy
Recruiting1 award1 criteria
Louisville, Colorado
This trial aims to test a new device that helps healthcare providers monitor the health of both the mother and baby during pregnancy and delivery. The study will compare this new device to the currently used Corometrics
Monoclonal Antibodies
GSK4418959 for Colorectal Cancer
Recruiting1 awardPhase 1 & 2
Denver, Colorado
This trial aims to investigate a new drug, GSK4418959, either alone or with another drug, for treating aggressive solid tumors with specific genetic traits. The study will evaluate the effectiveness, safety
Behavioural Intervention
Pramipexole vs Escitalopram for Depression in HIV
Recruiting1 awardPhase 2
Aurora, Colorado
This trial is comparing the safety and effectiveness of two different medications, pramipexole extended release and escitalopram, for treating major depressive disorder (MDD) in people with HIV.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.