Dr. Rayne H. Rouce
Claim this profileTexas Children's Hospital
Studies Acute Lymphoblastic Leukemia
Studies Lymphoblastic Leukemia-Lymphoma
9 reported clinical trials
20 drugs studied
Area of expertise
1Acute Lymphoblastic Leukemia
CD19 positive
CD5 positive
CD7 positive
2Lymphoblastic Leukemia-Lymphoma
CD19 positive
CD5 positive
CD7 positive
Affiliated Hospitals
Clinical Trials Rayne H. Rouce is currently running
CAR T-Cell Therapy
for Leukemia and Lymphoma
Patients with relapsed or refractory leukemia or lymphoma are often refractory to further chemotherapy. In this study, the investigators will attempt to use T cells obtained directly from the patient, which can be genetically engineered to express a chimeric antigen receptor (CAR). The CAR used in this study can recognize CD22, a protein expressed on the surface of leukemia and lymphoma cells. The phase 1 part of this study will determine the safety and appropriate dose level of these CAR T cells, and the phase 2 part of the study will determine how effective this CAR T cell therapy is. Both patients who have never had prior CAR T cell therapy and those who have had prior CAR T cell therapy may be eligible to participate in this study.
Recruiting1 award Phase 1 & 215 criteria
Stem Cell Transplantation
for Leukemia
This phase III trial compares hematopoietic (stem) cell transplantation (HCT) using mismatched related donors (haploidentical \[haplo\]) versus matched unrelated donors (MUD) in treating children, adolescents, and young adults with acute leukemia or myelodysplastic syndrome (MDS). HCT is considered standard of care treatment for patients with high-risk acute leukemia and MDS. In HCT, patients are given very high doses of chemotherapy and/or radiation therapy, which is intended to kill cancer cells that may be resistant to more standard doses of chemotherapy; unfortunately, this also destroys the normal cells in the bone marrow, including stem cells. After the treatment, patients must have a healthy supply of stem cells reintroduced or transplanted. The transplanted cells then reestablish the blood cell production process in the bone marrow. The healthy stem cells may come from the blood or bone marrow of a related or unrelated donor. If patients do not have a matched related donor, doctors do not know what the next best donor choice is. This trial may help researchers understand whether a haplo related donor or a MUD HCT for children with acute leukemia or MDS is better or if there is no difference at all.
Recruiting2 awards Phase 3
More about Rayne H. Rouce
Clinical Trial Related1 year of experience running clinical trials · Led 9 trials as a Principal Investigator · 5 Active Clinical TrialsTreatments Rayne H. Rouce has experience with
- Fludarabine
- Cyclophosphamide
- CTL019
- Tisagenlecleucel
- Allogeneic CD5.CAR/28zeta CAR T Cells
- Autologous CD5.CAR/28zeta CAR T Cells
Breakdown of trials Rayne H. Rouce has run
Acute Lymphoblastic Leukemia
Lymphoblastic Leukemia-Lymphoma
Non-Hodgkin's Lymphoma
Lymphoma
Other Doctors you might be interested in
Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Rayne H. Rouce specialize in?
Rayne H. Rouce focuses on Acute Lymphoblastic Leukemia and Lymphoblastic Leukemia-Lymphoma. In particular, much of their work with Acute Lymphoblastic Leukemia has involved CD19 positive patients, or patients who are CD5 positive.
Is Rayne H. Rouce currently recruiting for clinical trials?
Yes, Rayne H. Rouce is currently recruiting for 5 clinical trials in Houston Texas. If you're interested in participating, you should apply.
Are there any treatments that Rayne H. Rouce has studied deeply?
Yes, Rayne H. Rouce has studied treatments such as Fludarabine, Cyclophosphamide, CTL019.
What is the best way to schedule an appointment with Rayne H. Rouce?
Apply for one of the trials that Rayne H. Rouce is conducting.
What is the office address of Rayne H. Rouce?
The office of Rayne H. Rouce is located at: Texas Children's Hospital, Houston, Texas 77030 United States. This is the address for their practice at the Texas Children's Hospital.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.