Dr. Sharmila Dorbala, MBBS, MPH
Claim this profileBrigham and Women's Hospital
Studies Primary Cutaneous Amyloidosis
Studies Cardiac Amyloidosis
4 reported clinical trials
6 drugs studied
Affiliated Hospitals
Clinical Trials Sharmila Dorbala, MBBS, MPH is currently running
Ultrasound Therapy
for Cardiac Amyloidosis
This is a prospective pilot clinical study of subjects with cardiac amyloidosis and control subjects without amyloidosis where we plan to evaluate changes in myocardial blood flow, systolic and diastolic function before and after sonotherapy.
Recruiting3 awards Phase 45 criteria
[68Ga]CBP8 PET/MRI Imaging
for Cardiac Amyloidosis
The primary aim of our pilot study is to determine whether fibrosis in the heart can be measured with \[68Ga\]CBP8, a positron emission tomography (PET) probe, using PET/magnetic resonance imaging (MRI) imaging, in 30 individuals with documented cardiac amyloidosis. The investigators will also enroll 15 individuals with recent myocardial infarction and 15 individuals with hypertrophic cardiomyopathy as positive controls for fibrosis, and the investigators will enroll 5 individuals without cardiovascular disease to undergo \[68Ga\]CBP8 PET/MRI imaging as a healthy control group. The primary hypothesis of this study is that \[68Ga\]CBP8 will bind to interstitial collagen and quantify myocardial fibrosis in patients with cardiac amyloidosis. The investigators hypothesize that \[68Ga\]CBP8 uptake will be greater in patients with cardiac amyloidosis, myocardial fibrosis, and hypertrophic cardiomyopathy than in healthy controls. Secondly, the investigators also hypothesize that \[68Ga\]CBP8 activity more strongly correlates with standard MRI measures in patients with recent myocardial infarction and hypertrophic cardiomyopathy (where extracellular expansion is caused by myocardial fibrosis/collagen deposition) than in patients with cardiac amyloidosis (where myocardial fibrosis is combined with infiltration).
Recruiting1 award Phase 35 criteria
More about Sharmila Dorbala, MBBS, MPH
Clinical Trial Related1 year of experience running clinical trials · Led 4 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Sharmila Dorbala, MBBS, MPH has experience with
- F-18 Florbetapir/C-11 Acetate PET
- MRI
- N-13 Ammonia PET
- [68Ga]CBP8 PET/MRI
- Sonotherapy
- F-18 Florbetapir PET
Breakdown of trials Sharmila Dorbala, MBBS, MPH has run
Primary Cutaneous Amyloidosis
Cardiac Amyloidosis
Uraemic Cardiomyopathy
Cardiomyopathy
Other Doctors you might be interested in
Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Sharmila Dorbala, MBBS, MPH specialize in?
Sharmila Dorbala, MBBS, MPH focuses on Primary Cutaneous Amyloidosis and Cardiac Amyloidosis. In particular, much of their work with Primary Cutaneous Amyloidosis has involved TTR positive patients, or patients who are undergoing treatment.
Is Sharmila Dorbala, MBBS, MPH currently recruiting for clinical trials?
Yes, Sharmila Dorbala, MBBS, MPH is currently recruiting for 3 clinical trials in Boston Massachusetts. If you're interested in participating, you should apply.
Are there any treatments that Sharmila Dorbala, MBBS, MPH has studied deeply?
Yes, Sharmila Dorbala, MBBS, MPH has studied treatments such as F-18 florbetapir/C-11 acetate PET, MRI, N-13 ammonia PET.
What is the best way to schedule an appointment with Sharmila Dorbala, MBBS, MPH?
Apply for one of the trials that Sharmila Dorbala, MBBS, MPH is conducting.
What is the office address of Sharmila Dorbala, MBBS, MPH?
The office of Sharmila Dorbala, MBBS, MPH is located at: Brigham and Women's Hospital, Boston, Massachusetts 02115 United States. This is the address for their practice at the Brigham and Women's Hospital.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.