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Flovent vs Asmanex
Introduction
For individuals suffering from chronic respiratory conditions such as asthma, certain medications can help in managing symptoms by reducing inflammation and improving air flow. Flovent and Asmanex are two such drugs that are often prescribed for asthma patients. Both these drugs belong to the class of corticosteroids which work by decreasing inflammation in the lungs, but they differ in their formulation and dosage forms.
Flovent (fluticasone propionate) is available as a metered-dose inhaler while Asmanex (mometasone furoate) comes as a twisthaler device. Flovent acts on glucocorticoid receptors to reduce inflammatory response whereas Asmanex, apart from acting on glucocorticoid receptors also inhibits multiple cells like mast cells, eosinophils etc., involved in asthmatic response. Therefore, both have unique ways of modulating the immune system's response thus aiding relief from asthmatic symptoms. It’s important for each patient to discuss with their provider about which option may be best suited for them based on individual health history.
Flovent vs Asmanex Side By Side
| Attribute | Flovent | Asmanex |
|---|---|---|
| Brand Name | Flovent | Asmanex |
| Contraindications | Should not be taken if suffering from certain types of infections such as tuberculosis (TB), fungal infections, or viral infections like chickenpox and measles unless advised by a physician. May worsen symptoms of asthma in some people. | Should not be taken if suffering from certain types of infections such as tuberculosis (TB), fungal infections, or viral infections like chickenpox and measles unless advised by a physician. May worsen symptoms of asthma in some people. |
| Cost | $260 for a 120 dose inhaler | $230 for a 120 dose inhaler |
| Generic Name | fluticasone propionate | mometasone furoate |
| Most Serious Side Effect | Can occasionally cause a rapid or uneven heart rate, chest pain, tremors or nervousness. In rare instances, it may result in vision problems such as blurred vision, tunnel vision, eye pain, or swelling. | Signs of an allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Symptoms of a hormonal disorder: unusual tiredness or weakness, sudden weight loss or gain, increased thirst and urination. Vision problems such as blurry vision or other changes in eyesight. Mood changes like feelings of depression or agitation. |
| Severe Drug Interactions | Not specifically mentioned in the article, but as a corticosteroid, it could interact with drugs that suppress the immune system. | Not specifically mentioned in the article, but as a corticosteroid, it could interact with drugs that suppress the immune system. |
| Typical Dose | For adults and adolescents aged 12 years and older, dosages range from 88 to 880 mcg twice daily. For children aged 4 to 11, the starting dosage is 88 mcg twice a day. | Typically initiated at a dosage of 220 mcg once daily in the evening. The dosage can then be increased to 440 mcg, still taken once daily in the evening. |
What is Flovent?
Fluticasone propionate (the generic name for Flovent) is a corticosteroid that reduces inflammation in the airways, aiding in easier breathing. It was first approved by the FDA in 1990, marking a significant development from previous asthma treatments. Flovent operates by reducing swelling and irritation within the airways, thereby allowing more efficient passage of air. This drug is prescribed primarily for chronic conditions such as asthma and does not work immediately during an active asthma attack.
On the other hand, Mometasone furoate (commonly known as Asmanex) also belongs to the class of medications known as corticosteroids and functions similarly to Flovent. Both drugs are designed with similar goals - to manage and prevent symptoms caused by asthma; however, they differ slightly in their delivery methods and dosage instructions.
Flovent has been widely recognized for its effective yet gentle action on inflamed bronchial tubes but may have minor influence on adrenal gland function at high doses compared to Asmanex's lower systemic effects due to its higher topical potency.
What conditions is Flovent approved to treat?
Flovent is used for the management of asthma symptoms in patients aged 4 years and older as a maintenance therapy:
- Chronic treatment of asthma to reduce inflammation and associated airway constriction
- Prophylactic therapy to prevent or lessen the severity of asthmatic attacks
- Not suitable for relief during an acute bronchospasm (an immediate-relief inhaler would be necessary)
How does Flovent help with these illnesses?
Flovent helps to manage asthma by reducing inflammation in the airways of the lungs. It accomplishes this by inhibiting the release of substances in the body that cause inflammation. Flovent is a corticosteroid, a type of hormone that plays an essential role in regulating immune responses and reducing inflammation. Asthma patients often have inflamed airways which can make it more difficult for air to move in and out, leading to symptoms like shortness of breath, coughing, wheezing and chest tightness. By reducing this inflammation with regular use, Flovent can limit these symptoms and help patients control their asthma better.
What is Asmanex?
Asmanex is a brand name for mometasone, which is a glucocorticoid or steroidal anti-inflammatory. It works by reducing the inflammation in the airways, helping individuals with conditions such as asthma to breathe more easily. Mometasone was first approved by the FDA in 1987 and is usually administered via an inhaler device.
Unlike Flovent (fluticasone), Asmanex does not have a strong mineralocorticoid effect, meaning it has less potential to cause fluid retention and high blood pressure - common side effects associated with other corticosteroids. Asmanex's specific action on immune cells within lung tissue makes its side-effect profile different from that of many systemic steroids, particularly regarding weight gain and bone density reduction.
The targeted effects of Asmanex can be beneficial for treating persistent asthma especially in patients who do not respond well to "typical" bronchodilators like albuterol. Always remember that these medications should be used under proper medical supervision.
What conditions is Asmanex approved to treat?
Asmanex is an approved medication for the management and prevention of asthma symptoms in patients aged 4 years and older. Specifically, it is indicated for:
- The maintenance treatment of asthma as prophylactic therapy.
- It may also be used for long-term asthma control in some individuals.
How does Asmanex help with these illnesses?
Corticosteroids are a class of drugs that reduce inflammation in the body, which can be particularly helpful for conditions like asthma. Asmanex is one such corticosteroid that works by reducing inflammation and swelling in the airways to improve breathing and control symptoms of asthma. Similar to its counterpart Flovent, Asmanex targets glucocorticoid receptors within the cells involved in immune responses, thereby inhibiting inflammatory reactions. However, unlike Flovent, Asmanex tends to produce fewer systemic side effects due to its lower bioavailability after inhalation. This makes it an alternative option when patients do not respond well or experience adverse effects from other typical corticosteroids such as Flovent. It may also be combined with bronchodilators or other anti-asthmatic medications for a more comprehensive approach towards managing this chronic respiratory disease.
How effective are both Flovent and Asmanex?
Both fluticasone propionate (Flovent) and mometasone furoate (Asmanex) have well-documented histories of effectiveness in managing asthma symptoms. They were initially approved by the FDA within a few years of each other, with Flovent gaining approval in 1996 and Asmanex following shortly after in 2004. These two corticosteroids work similarly to reduce inflammation within the airways, making them key components for many patients' asthma management plans.
A direct comparison study between these two drugs reported comparable efficacy rates in reducing overall asthma symptom scores. Neither drug was found to be superior over the other when it came to controlling asthma flare-ups or improving lung function tests during this study. Additionally, both medications demonstrated similar safety profiles with minimal side effects mostly confined to mild throat irritation and oral candidiasis.
In terms of usage, a review from 2010 indicated that fluticasone's optimal dose is generally considered as twice daily due its shorter half-life while mometasone can be used once daily due its longer duration action which could lead better compliance among patients who prefer less frequent dosing.
While both steroids are equally effective at controlling inflammation and preventing asthmatic episodes, one might be preferred over the other depending on individual patient needs such as adherence to medication schedule or susceptibility to certain side effects like throat irritation or oral fungal infections.
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At what dose is Flovent typically prescribed?
Inhaled dosages of Flovent for adults and adolescents aged 12 years and older range from 88 to 880 mcg twice daily. However, lower starting doses (88-220 mcg twice daily) are generally sufficient for treating asthma in most people. Children aged 4 to 11 may be started on a dosage of 88 mcg twice a day. In either population, if the symptoms persist or worsen over time, the dosage can be increased but should not exceed the maximum recommended dose of 880 mcg per day in any case.
At what dose is Asmanex typically prescribed?
Asmanex treatment is typically initiated at a dosage of 220 mcg once daily in the evening. The dosage can then be increased to 440 mcg, still taken once daily in the evening, if necessary and as directed by a healthcare provider. It's important to know that the maximum recommended dose for Asmanex is 440 mcg per day. If there’s no significant improvement or control over asthma symptoms after two weeks of therapy at this dosage, re-evaluation may be needed and alternative therapeutic options should be considered.
What are the most common side effects for Flovent?
Common side effects of Flovent and Asmanex may include:
- Headache or dizziness
- Nausea, vomiting, upset stomach
- Dry mouth/throat and hoarseness
- Cough or throat irritation
- Stuffy nose, sinus pain, sneezing
- Changes in voice
- Muscle weakness or tired feeling (asthenia)
- Infections such as the flu (influenza) or cold symptoms
- Redness, rash or itching skin around the application area
Please note that both medications could also possibly cause more serious side effects like weakening of bones with long-term use, cataracts, glaucoma and slower growth rates in children. Always inform your healthcare provider if you experience any unusual side effects after starting a new medication.
Are there any potential serious side effects for Flovent?
Flovent and Asmanex are both corticosteroid medications used to control and prevent symptoms caused by asthma. While they have similar uses, their potential side effects do differ:
- Flovent can occasionally cause a rapid or uneven heart rate, chest pain, tremors or nervousness. In rare instances, it may result in vision problems such as blurred vision, tunnel vision, eye pain or swelling.
- Signs of allergic reaction with either medication include hives; difficulty breathing; swelling of the face, lips, tongue or throat.
- With Asmanex there is a slight risk of experiencing changes in mood - including depression or feelings of extreme happiness; strange thoughts or behavior (such as confusion), sleep problems (insomnia); seizures (convulsions); muscle weakness and fatigue.
Both Flovent and Asmanex could lead to bone loss if used over long periods. If you experience any severe side effects while using these drugs please contact your healthcare professional immediately for advice.
What are the most common side effects for Asmanex?
Asmanex, another option for asthma management, has its own set of potential side effects. Some may experience a cough, sore throat or hoarseness due to the medication. It can cause headaches and sinus inflammation leading to symptoms like stuffy nose. Asmanex might also lead to upset stomach or nausea in some individuals. Though less common, it can potentially induce sleep problems like insomnia as well as muscle or joint pain. In rare instances, weight gain rather than loss may be observed with long-term use of Asmanex due to its corticosteroid nature. If you notice mood changes such as agitation and nervousness while using this drug, it's crucial that you discuss these issues with your healthcare provider promptly.
Are there any potential serious side effects for Asmanex?
While Asmanex is generally well-tolerated, it's important to monitor the following rare but potentially serious side effects:
- Signs of an allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing
- Symptoms of a hormonal disorder: unusual tiredness or weakness, sudden weight loss or gain, increased thirst and urination
- Vision problems such as blurry vision or other changes in eyesight
- Mood changes like feelings of depression or agitation
- Increased wheezing/shortness of breath immediately after using Asmanex. This could be a sign that your asthma is getting worse.
If you experience any signs from the list above while taking Asmanex, contact your healthcare provider promptly for further advice.
Contraindications for Flovent and Asmanex?
Both Flovent and Asmanex, along with most other corticosteroid medications, may worsen symptoms of asthma in some people. If you notice your asthma worsening or an increase in shortness of breath, wheezing or chest tightness, please seek immediate medical attention.
Neither Flovent nor Asmanex should be taken if you are suffering from certain types of infections such as tuberculosis (TB), fungal infections or viral infections like chickenpox and measles unless advised by your physician. Always inform your doctor about any current infection; these conditions may need to be controlled before starting treatment with Flovent or Asmanex.
Moreover, corticosteroids can suppress the immune system making it harder for your body to fight off infections. Thus, it's vital that patients taking either medication steer clear of people with contagious illnesses and report any signs of infection to their doctors promptly.
How much do Flovent and Asmanex cost?
For the brand name versions of these drugs:
- The price of Flovent (fluticasone propionate), an inhaler with 120 doses, averages around $260. This works out to approximately $2.10 per day for one puff per day.
- In comparison, Asmanex (mometasone furoate) is priced at roughly $230 for a 120 dose inhaler which amounts to about $1.90 per day if used regularly once a day.
Thus, on a daily treatment basis and assuming regular use of just one puff/day, Asmanex comes out as slightly less expensive than Flovent. However, cost should not be your primary consideration in determining which drug is right for you.
Currently there are no generic versions available for both Flovent and Asmanex; they're only available as brand-name medicines in the United States market.
Popularity of Flovent and Asmanex
Fluticasone, available under the brand name Flovent among others, was estimated to have been prescribed to about 4.1 million people in the US in 2020. Fluticasone accounted for just over 8% of inhaled corticosteroid prescriptions in the US. It's a popular drug due to its long half-life and potent anti-inflammatory effects which help manage asthma symptoms.
Mometasone, including brand versions such as Asmanex, was prescribed to approximately 2.7 million people in the USA during that same period. In terms of overall inhalant corticosteroids use, mometasone accounts for around 5%. The prevalence of both fluticasone and mometasone has remained very steady over recent years with little variation seen between them.
Both are used primarily as maintenance treatment options for managing chronic asthma symptoms but differ slightly when it comes to their dosing schedules — fluticasone is typically administered twice daily while mometasone is usually given once daily at bedtime.
Conclusion
Both Flovent (fluticasone) and Asmanex (mometasone) are long-standing members of the inhaled corticosteroids family used to manage symptoms in patients with asthma. They have been backed by numerous clinical studies indicating their effectiveness over placebo treatments. Due to their different pharmacokinetic profiles, they may be prescribed under varying circumstances although both primarily work by reducing inflammation within the airways.
Flovent is often considered as a first-line treatment option for persistent asthma due to its effective symptom control and safety profile. On the other hand, Asmanex might be considered as an alternative therapy or addition for those who did not respond well to initial treatment options or have specific needs such as once-daily dosing convenience.
Both medications are available in generic form providing significant cost savings especially for patients paying out of pocket. Both Flovent and Asmanex require consistent usage meaning that full benefits may not be noticeable right away but develop over time with regular use.
The side effect profile is similar between these two drugs, both being generally well-tolerated but could cause throat irritation or fungal infection in mouth/throat if proper inhalation technique isn't followed. For both medications, it's important that patients closely monitor their breathing when starting treatment, and should seek medical help immediately if they notice any worsening of asthma symptoms.
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Refrences
- Staresinic, A. G., & Sorkness, C. A. (2000, September). Fluticasone propionate: a potent inhaled corticosteroid for the treatment of asthma. Expert Opinion on Pharmacotherapy. Informa UK Limited.http://doi.org/10.1517/14656566.1.6.1227
- Harnest, U., Price, D., Howes, T., & Sussman, G. (2008, January). Comparison of Mometasone Furoate Dry Powder Inhaler and Fluticasone Propionate Dry Powder Inhaler in Patients with Moderate to Severe Persistent Asthma Requiring High-Dose Inhaled Corticosteroid Therapy: Findings from a Noninferiority Trial. Journal of Asthma. Informa UK Limited.http://doi.org/10.1080/02770900801890646