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Remote Ischemic Conditioning for Limited Mobility

N/A
Waitlist Available
Led By W Todd Cade, PhD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to post-intervention visit (approximately 7 weeks)

Summary

This trial aims to see if a technique called remote ischemic conditioning can help improve muscle strength, exercise tolerance, and overall quality of life in individuals over 65 who have mobility issues.

Who is the study for?
This trial is for people over 65 who have trouble moving around, possibly due to aging, weakness, or frailty. Participants should be able to perform some low-intensity exercises and must not have conditions that would make the trial unsafe or unsuitable for them.
What is being tested?
The study is testing whether adding remote ischemic conditioning (RIC) to low-intensity resistance exercise can improve muscle strength, mass, exercise tolerance, resilience, quality of life and physical function in older adults with limited mobility.
What are the potential side effects?
While specific side effects are not detailed here, RIC generally involves brief and repeated interruptions of blood flow which might cause discomfort. Exercise may lead to muscle soreness or fatigue.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to post-intervention visit (approximately 7 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to post-intervention visit (approximately 7 weeks) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Acceptability of study intervention as measured by an Intervention Acceptability Questionnaire
Feasibility of study intervention as measured by the attrition rate
Secondary study objectives
Change in Brief Resilience 5-point Likert Scale
Change in Short Physical Performance Battery (SPPB)
Change in muscle strength as measured by dynamometry

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: High-Dose RIC (Remote Ischemic Conditioning) InterventionActive Control2 Interventions
Low-intensity resistance exercise training plus high-dose RIC.
Group II: Low-Dose RIC InterventionPlacebo Group2 Interventions
Low-intensity resistance exercise training plus low-dose RIC.

Find a Location

Who is running the clinical trial?

National Institutes of Health (NIH)NIH
2,840 Previous Clinical Trials
8,172,600 Total Patients Enrolled
Duke UniversityLead Sponsor
2,463 Previous Clinical Trials
2,981,840 Total Patients Enrolled
W Todd Cade, PhDPrincipal InvestigatorDuke University
~13 spots leftby Jun 2026
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