Remote Ischemic Conditioning for Limited Mobility

Recruiting in Palo Alto (17 mi)

Overseen byW Todd Cade, PhD

Age: 65+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Duke University

Approved in 2 Jurisdictions

Trial Summary

What is the purpose of this trial?The purpose of this study is to examine the feasibility and acceptability of a technique called remote ischemic conditioning (RIC) that aims to improve muscle strength, muscle mass, exercise tolerance, resilience (i.e. how well someone responds to a stressor), quality of life, physical activity, and physical function when added to rehabilitative exercise training in individuals over age 65 who have some difficulty with mobility.

Eligibility Criteria

This trial is for people over 65 who have trouble moving around, possibly due to aging, weakness, or frailty. Participants should be able to perform some low-intensity exercises and must not have conditions that would make the trial unsafe or unsuitable for them.

Inclusion Criteria

I am 65 or older and have been referred to an exercise program because of functional decline, getting weaker, or risk of falling.

Exclusion Criteria

I can follow instructions and safely do exercises.

I don't have any health conditions that prevent me from doing exercise tests.

My heart condition is stable.

Participant Groups

The study is testing whether adding remote ischemic conditioning (RIC) to low-intensity resistance exercise can improve muscle strength, mass, exercise tolerance, resilience, quality of life and physical function in older adults with limited mobility.

2Treatment groups

Active Control

Placebo Group

Group I: High-Dose RIC (Remote Ischemic Conditioning) InterventionActive Control2 Interventions

Low-intensity resistance exercise training plus high-dose RIC.

Group II: Low-Dose RIC InterventionPlacebo Group2 Interventions

Low-intensity resistance exercise training plus low-dose RIC.