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Nasonex vs Allegra
Introduction
For patients suffering from seasonal allergies or other types of persistent nasal symptoms, certain medications that inhibit the body's immune response to allergens can help in managing these uncomfortable occurrences. Nasonex and Allegra are two such drugs that are often prescribed for allergy relief. They each function differently but both have significant effects in alleviating allergy symptoms. Nasonex is a corticosteroid nasal spray, impacting inflammation levels directly at the source by reducing swelling and irritation in the nose. Allegra, on the other hand, is classified as an antihistamine which works systemically by blocking histamines - substances your body produces during an allergic reaction - throughout your whole body. Therefore, while Allegra might also relieve itchiness of eyes or skin aside from sneezing and runny noses, Nasonex primarily focuses its effect within nasal passages.
Nasonex vs Allegra Side By Side
| Attribute | Nasonex | Allegra |
|---|---|---|
| Brand Name | Nasonex | Allegra |
| Contraindications | Should not be taken if using certain antifungal or antibiotic medications such as ketoconazole and erythromycin. Not recommended if there is an untreated infection in the nose area, recent nasal ulcers, surgery, or injury. | Should not be taken with certain antifungal or antibiotic medications. Dosage adjustment may be needed for those with kidney disease. |
| Cost | Brand name: around $240 for 17 grams (120 sprays); Generic: between $50 and $100 for 17 grams | Brand name: about $20 for 30 tablets (180 mg each); Generic: starting from around $10 for thirty 180mg tablets |
| Generic Name | Mometasone furoate monohydrate | Fexofenadine hydrochloride |
| Most Serious Side Effect | Signs of an allergic reaction, sores or white patches inside or around your nose, blurred vision, fever, chills | Allergic reaction signs, rapid heartbeat or fluttering in your chest, confusion and dizziness, trouble urinating, feeling restless or excited |
| Severe Drug Interactions | Certain antifungal or antibiotic medications such as ketoconazole and erythromycin | Certain antifungal or antibiotic medications |
| Typical Dose | For adults and children over 12: two sprays in each nostril once daily. For children 2 to 11: one spray in each nostril per day. | For adults and children over 12: 60 mg twice daily or 180 mg once per day. For children 6 to 11: 30mg twice a day. |
What is Nasonex?
Mometasone furoate (the generic name for Nasonex) is a glucocorticoid steroid for topical application, particularly used in the treatment of allergic rhinitis and nasal polyps. It was first approved by the FDA in 1997. Nasonex works by reducing inflammation and swelling in the nasal passages, effectively alleviating symptoms such as congestion, sneezing, and runny nose caused by seasonal or perennial allergies.
On the other hand, Fexofenadine (commonly known as Allegra), is an antihistamine that reduces effects of natural chemical histamines in the body which can produce symptoms like itching, watery eyes, runny nose or sneezing. Being second generation antihistamines it has fewer side effects than traditional ones with minimal sedative effect.
Though both are used to treat allergy symptoms their method of action differs significantly; while Nasonex targets inflammation provoked by an overactive immune response directly at its source within your nasal passage itself , Allegra operates more generally throughout your body to block histamine receptors thereby preventing allergic reactions.
What conditions is Nasonex approved to treat?
Nasonex is approved for the treatment of various conditions related to allergies and nasal polyps:
- Seasonal and perennial allergic rhinitis, commonly known as hay fever
- Nasal congestion associated with seasonal allergic rhinitis
- Prophylaxis of seasonal allergic rhinitis symptoms
- Nasal polyps in patients 18 years of age or older
How does Nasonex help with these illnesses?
Nasonex, a type of nasal spray, aids in managing allergy symptoms by reducing inflammation in the nasal passages. It accomplishes this through its active ingredient, mometasone furoate, which is a corticosteroid. This compound inhibits immune responses and reduces swelling and irritation within the nose. Inflammation plays an important role in the body's response to allergens such as pollen or dander; it leads to common allergic reactions like sneezing, runny nose or congestion.
In contrast to Nasonex's local action on inflamed nasal tissue, Allegra (fexofenadine) operates systemically – meaning it has effects throughout the body – blocking histamine receptors and thus preventing histamine from causing allergic reactions. Histamine is a chemical that acts as an alarm signal when your body encounters harmful substances; however, in cases of allergies where these substances aren't actually dangerous for you personally (like pollen), this signaling can be overly aggressive leading to uncomfortable symptoms.
While both Nasonex and Allegra work towards relieving allergy symptoms their different mechanisms might make one more suitable than another depending on factors such as severity of symptoms or desired speed of relief onset.
What is Allegra?
Allegra is a brand name for fexofenadine, an antihistamine that works by blocking histamines in the body. These are chemicals responsible for allergic symptoms such as runny nose, itching or sneezing. Unlike some other antihistamines, Allegra does not cross into the brain from the blood and therefore causes less drowsiness. This makes it particularly useful for daytime use when alertness is required.
Fexofenadine was first approved by the FDA in 1996 and has been used extensively since then to treat symptoms of seasonal allergies and chronic urticaria (hives). Its side effect profile tends to be mild with headaches being most commonly reported but rarely causing discontinuation of treatment. The non-drowsy nature of Allegra helps separate it from many other allergy medications which can cause significant sedation.
What conditions is Allegra approved to treat?
Allegra, also known by its generic name fexofenadine, has received approval for the treatment of:
- Seasonal allergic rhinitis (hay fever)
- Chronic idiopathic urticaria (hives not caused by a specific trigger) By alleviating these symptoms, Allegra can help you get through allergy season with fewer discomforts and disruptions to your daily life.
How does Allegra help with these illnesses?
Histamine is a compound involved in local immune and inflammatory responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It plays a central role in allergic reactions by dilating blood vessels and making them more permeable. Allegra works by inhibiting the action of histamine at H1 receptor sites thereby reducing or preventing many of the symptoms associated with allergies like runny nose, itching eyes/nose/throat, sneezing, hives, and itchiness. Unlike Nasonex which is administered nasally to reduce inflammation directly in nasal passages affected by allergies or other conditions such as polyps or sinusitis; Allegra can be taken orally for systemic relief throughout your body without direct application to nasal tissues. This makes it especially beneficial for those suffering from widespread allergy symptoms beyond just nasal congestion or irritation.
How effective are both Nasonex and Allegra?
Both Mometasone (Nasonex) and Fexofenadine (Allegra) have established histories of success in treating patients with allergy symptoms. Nasonex, a corticosteroid nasal spray, was first approved by the FDA in 1997 while Allegra, an antihistamine, received its approval only three years later in 2000. Both medications act on different pathways to control allergic reactions; Nasonex reduces inflammation in the nasal passages whilst Allegra blocks histamines that cause itching and sneezing.
The effectiveness of both drugs has been directly studied in numerous clinical trials over the past two decades. A double-blind study conducted between these two medications revealed that they were equally effective at managing symptoms such as itchy or runny nose, sneezing, and watery eyes caused by seasonal allergies. However, another study showed that for perennial allergies like dust mites or pet dander where nasal congestion is common symptomatology, adding a topical steroid like Nasonex can significantly improve symptom relief compared to antihistamines alone.
A review conducted in 2011 demonstrated that fexofenadine is well-tolerated even among pediatric populations with minimal side effects reported across various age groups from children to adults. The optimal dosage recommended is usually between 60mg-180mg/day depending on the severity of symptoms which seems to provide maximum relief without causing any sedation or other adverse effects unlike some older generation antihistamines.
On the other hand, mometasone has consistently proven itself as an excellent treatment option for controlling moderate-severe allergy symptoms especially those associated with chronic rhinitis including post-nasal drip and sinus pressure beyond just regular sneezing or itching due its anti-inflammatory properties.
In conclusion though both are highly effective options for managing allergic rhinitis; one might be preferred over another based on individual patient needs such as presence of specific types of allergies(seasonal vs perennial), prevalence/severity of certain symptoms(nasal blockade vs itchy eyes), risk tolerance towards potential side-effects(sedation etc.), age group(pediatric vs adult) etc.
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At what dose is Nasonex typically prescribed?
Nasonex nasal spray dosage for adults and children over 12 is typically two sprays in each nostril once daily, or as directed by a healthcare provider. For children between the ages of 2 to 11, it's usually one spray in each nostril per day. On the other hand, Allegra dosages vary depending on the specific formulation. Adults and children over 12 can generally take a single dose of either Allegra 180 mg or Allegra-D (with decongestant) every day for up to two weeks. Children aged six through eleven should take no more than one dose of Allegra 30mg twice daily under adult supervision. Dosage adjustments may be needed based on individual response after a few days or weeks.
At what dose is Allegra typically prescribed?
Allegra treatment is typically initiated at a dosage of 60 mg twice daily or 180 mg once per day for adults and children over the age of twelve. The dose should not exceed these recommendations. For children between six and eleven years old, the usual starting dose is 30mg twice a day. This may then be adjusted as necessary based on response to treatment; however, it should never exceed the maximum allotted amounts. Allegra's effects are usually felt within an hour after intake and last for about 24 hours, making it ideal for managing symptoms throughout the entire day with just one dose.
What are the most common side effects for Nasonex?
Common side effects of Nasonex include:
- Headache
- Viral infection (such as the common cold)
- Coughing
- Nosebleeds
- Sore throat
- Pain in muscles or joints
- Nasal irritation or burning
Meanwhile, Allegra can cause side effects such as:
- Dizziness
- Headaches
- Diarrhea -Nausea.
It's worth noting that every individual may react differently to medications and while these are commonly reported symptoms, it doesn't mean they'll occur in everyone who takes these drugs. Always consult a healthcare professional with any concerns about potential side effects.
Are there any potential serious side effects for Nasonex?
Nasonex and Allegra are both generally considered safe, but like all medications, they can occasionally cause side effects. For Nasonex, these may include:
- Signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue or throat
- Sores or white patches inside or around your nose
- Nosebleeds
- Blurred vision, tunnel vision, eye pain or redness;
- Fever
- Chills.
Allegra's potential side effects might include:
- Symptoms like a flu such as fever, chills and body aches
- Coughing up thick mucus
- Rapid heart rate
- Feeling nervous or restless.
If you experience any severe symptoms while taking either medication - including those listed above - please stop the medication immediately and contact your healthcare provider.
What are the most common side effects for Allegra?
Allegra, an over-the-counter antihistamine, commonly used to treat hay fever and hives, can cause different types of side effects:
- Dry mouth or throat
- Nausea or upset stomach
- Drowsiness or fatigue
- Headache
- Muscle or back pain
While these side effects are typically mild and temporary, if they persist or worsen it is important to contact a healthcare provider. Just like any medication, Allegra may not be suitable for everyone and should be taken as directed.
Are there any potential serious side effects for Allegra?
Allegra, while generally well-tolerated, can cause adverse effects in some cases. It's essential to be aware of potential symptoms that may indicate serious reactions:
- Allergic reaction signs such as hives; difficulty breathing; swelling of your face, lips, tongue, or throat
- Rapid heartbeat or fluttering in your chest
- Confusion and dizziness
- Trouble urinating (especially an older male)
- Dry mouth and a dry cough
- Feeling restless or excited (especially in children)
If you experience any of these side effects while taking Allegra, it is crucial to seek medical attention promptly.
Contraindications for Nasonex and Allegra?
Both Nasonex and Allegra, as with most other allergy medications, may exacerbate symptoms in some individuals. If you notice your allergic reactions worsening or any unusual side effects after taking these drugs, it's crucial to seek immediate medical attention.
Neither Nasonex nor Allegra should be taken if you are using certain types of antifungal or antibiotic medications such as ketoconazole and erythromycin respectively. Always inform your physician about all the medicines you are currently taking; these include prescription drugs, over-the-counter products and even herbal supplements. Certain drug interactions can alter how your medication works or increase the risk for serious side effects.
For those with kidney disease who require a dosage adjustment while on Allegra, consult a healthcare professional before starting treatment. Similarly, if you have an infection in the nose area (such as herpes simplex) that has not been treated yet or recent nasal ulcers/surgery/injury leading to soreness or delay healing while on Nasonex - it is recommended to talk through this with your doctor.
How much do Nasonex and Allegra cost?
For the brand name versions of these drugs:
- The price of 17 grams (120 sprays) of Nasonex averages around $240, which works out to about $8/day if you use two sprays in each nostril once daily.
- The price for a box of 30 tablets (180 mg each) Allegra is about $20, working out to approximately $0.67/day.
Thus, if you are using two sprays per day of Nasonex as recommended, then brand-name Allegra is less expensive on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which one these drugs suit your condition better.
In terms of generic versions:
- Mometasone furoate monohydrate, the active ingredient in Nasonex, costs significantly less at roughly between $50 and $100 for 17 grams.
- Fexofenadine hydrochloride is available as an over-the-counter medication with prices starting from as low as around $10 for thirty 180mg tablets or approximately $.33 cents/day.
Remember that while generics have the same active ingredients and effectiveness as branded medications they may vary slightly due to inactive components such fillers or colorings.
Popularity of Nasonex and Allegra
Mometasone furoate, in generic form as well as brand names such as Nasonex, was estimated to have been prescribed to about 2.6 million people in the US in 2020. Mometasone accounted for just over 10% of nasal spray prescriptions in the US. However, it appears to be the most-common “atypical” nasal corticosteroid (not classified as a broad class of antihistamines). The prevalence of mometasone has been generally increasing since its approval by FDA.
Fexofenadine hydrochloride, including brand versions such as Allegra, was prescribed to nearly 4 million people in the USA in 2020. In the US, fexofenadine accounts for just under 15% of H1 antagonist prescriptions and roughly around 7% overall allergy medication prescriptions. The prevalence of fexofenadine has remained approximately steady over the last decade.
Conclusion
Both Nasonex (mometasone) and Allegra (fexofenadine) have a long-standing record of usage in patients with allergies, supported by numerous clinical studies that indicate they are more effective than placebo treatments. They may be used in conjunction but careful consideration is required as this can increase the risk of side effects. Due to their different mechanisms of action, with Nasonex acting primarily as a glucocorticoid receptor agonist to decrease inflammation and Allegra functioning predominantly as an antihistamine, they tend to be prescribed under different circumstances. Nasonex is particularly beneficial for nasal symptoms such as congestion, sneezing or runny nose while Allegra works well for systemic allergy symptoms including itching, redness and hives.
Both drugs are available in generic form which offers significant cost savings especially for those paying out-of-pocket. Both Nasonex and Allegra may require some time before their full effect becomes noticeable.
The side effect profile is similar between the two drugs; both are generally well-tolerated though potential side effects include headache and dry mouth for both medications. As always, it's crucial that patients closely monitor any changes when starting treatment and seek medical help immediately if severe reactions occur.
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Refrences
- Baldwin, C. M., & Scott, L. J. (2008). Mometasone Furoate. Drugs. Springer Science and Business Media LLC.http://doi.org/10.2165/00003495-200868120-00009
- Smith, S. M., & Gums, J. G. (2009, June 22). Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opinion on Drug Metabolism & Toxicology. Informa Healthcare.http://doi.org/10.1517/17425250903044967
- Nelson, H. S., Reynolds, R., & Mason, J. (2000, May). Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria. Annals of Allergy, Asthma & Immunology. Elsevier BV.http://doi.org/10.1016/s1081-1206(10)62515-x
- Schenkel, E. (2003, September). Features of mometasone furoate nasal spray and its utility in the management of allergic rhinitis. Expert Opinion on Pharmacotherapy. Informa Healthcare.http://doi.org/10.1517/14656566.4.9.1579
- Gawchik, S., Goldstein, S., Prenner, B., & John, A. (2003, April). Relief of cough and nasal symptoms associated with allergic rhinitis by mometasone furoate nasal spray. Annals of Allergy, Asthma & Immunology. Elsevier BV.http://doi.org/10.1016/s1081-1206(10)61826-1