Your session is about to expire
Xanax vs Oxazepam
Introduction
For patients with anxiety disorders or symptoms of severe stress, certain drugs that influence the concentrations of compounds in the brain linked to relaxation and calming effects can help manage these conditions. Xanax and Oxazepam are two such drugs often prescribed for these purposes. They each impact different areas within the central nervous system but both have a tranquillizing effect in patients with anxiety disorders. Xanax is a short-acting benzodiazepine, affecting levels of gamma-aminobutyric acid (GABA) neurotransmitters which reduce neuron activity and result in calmness or relaxation. Oxazepam, on the other hand, is classified as a medium-to-long acting benzodiazepine also influencing GABA receptors albeit more slowly than Xanax; it's metabolized at a steady rate providing longer lasting relief from symptoms.
Xanax vs Oxazepam Side By Side
| Attribute | Xanax | Oxazepam |
|---|---|---|
| Brand Name | Xanax | Oxazepam |
| Contraindications | Worsening symptoms of depression, suicidal thoughts or behavior, concurrent or recent opioid use without medical supervision. | Worsening symptoms of depression, suicidal thoughts or behavior, concurrent or recent opioid use without medical supervision. |
| Cost | Brand-name: Around $350 for 60 tablets (0.25 mg). Generic: Starting as low as $.06/pill to roughly $.45/pill | Brand-name: Approximately $70 for 30 capsules (10 mg). Generic: Approximate cost ranging between $.50 - $1 per pill. |
| Generic Name | Alprazolam | Oxazepam |
| Most Serious Side Effect | Severe allergic reactions, mental/mood changes such as hallucinations, thoughts about suicide or self-harm, abnormal voluntary movement control, rapid heartbeat, chest pain, unusual tiredness/weakness, yellowing eyes/skin. | Signs of an allergic reaction, unusual changes in mood or behavior including worsening depression or suicidal thoughts, confusion or hallucinations, hyperactivity, agitation, aggression or hostility, a light-headed feeling, jaundice. |
| Severe Drug Interactions | Concurrent use with opioids can lead to severe respiratory distress and even death. | Concurrent use with opioids can lead to severe respiratory distress and even death. |
| Typical Dose | 0.25–4 mg/day, starting dosage is usually 0.5 mg three times a day. | 10–15 mg three to four times per day, can be increased to 30-60 mg/day, up to a maximum of 120 mg/day. |
What is Xanax?
Alprazolam (the generic name for Xanax) is a drug that belongs to the benzodiazepine class of anxiolytics, which was a significant advancement from the traditional sedative-hypnotics. Alprazolam received FDA approval in 1981. Xanax works by enhancing the effect of a neurotransmitter called gamma-aminobutyric acid (GABA), slowing down brain activity and providing calming effects. It is commonly prescribed for different forms of anxiety disorders and panic attacks. Unlike other medications within its class, Xanax has selective influence on GABA receptors with less impact on histamine or acetylcholine receptors, resulting in it having fewer side effects than other anxiolytics that have stronger effects on these two other neurotransmitters.
On the contrary, Oxazepam (Serax) also belongs to the benzodiazepines family but tends to be slower acting with less severe withdrawal symptoms compared to alprazolam. This makes oxazepam more suitable for patients who need long-term management of their conditions rather than rapid relief from acute episodes.
What conditions is Xanax approved to treat?
Xanax has been approved for the treatment of various conditions including:
- Anxiety disorders, such as generalized anxiety disorder (GAD)
- Panic Disorder, with or without agoraphobia
- Short-term symptomatic relief of excessive anxiety in patients with depressive symptoms
How does Xanax help with these illnesses?
Xanax aids in managing anxiety and panic disorders by increasing the amount of gamma-aminobutyric acid (GABA) available in the synapses of the brain. GABA is a neurotransmitter that inhibits or slows down brain activity, contributing to calming effects and reduction of anxiety. Xanax enhances this effect by binding to GABA receptors, thus amplifying their impact, leading to increased sedation and relaxation in patients. It's believed that individuals with anxiety have relatively lower levels of GABA activity; therefore, by enhancing its function, Xanax can help limit negative feelings associated with anxiety and help patients manage their condition more effectively.
In contrast, Oxazepam also works on improving the action of GABA but has a slower onset than Xanax due to its longer half-life. It means it takes longer time for oxazepam to reach peak concentrations in your body after consumption which could be an advantage for those who experience side effects from fast-acting medications like Xanax or if they want continuous coverage against anxiety symptoms throughout the day without needing frequent dosing.
What is Oxazepam?
Oxazepam, which is marketed under various brand names including Serax and Adumbran, is a short-to-intermediate-acting benzodiazepine. Like Xanax, it operates by enhancing the effect of gamma-aminobutyric acid (GABA) in the brain to deliver its calming effects. However, Oxazepam differs from Xanax in that it doesn't affect dopamine or norepinephrine levels.
It's often used for relief of anxiety and tension linked to psychoneurosis and as an adjunctive therapy for anxiety disorders. The medication was first approved by the FDA in 1965. Oxazepam does not work immediately like some other benzodiazepines; instead, it has a slow onset time with less potential for abuse compared to similar treatments.
While side effects may include drowsiness and sedation at higher doses, these tend not be as pronounced as those seen with drugs like Xanax. Furthermore, unlike many other benzodiazepines such as Xanax that are metabolized by complex processes within the liver before being excreted by the body - Oxazepam undergoes simpler metabolic processes making it safer for individuals with compromised liver function.
What conditions is Oxazepam approved to treat?
Oxazepam is an official medication approved for the treatment of various conditions such as:
- Anxiety disorders or short-term relief of anxiety symptoms
- Alcohol withdrawal, including agitation and tremors
It's important to note that Oxazepam should be used under medical supervision due to its potential for dependence and other side effects.
How does Oxazepam help with these illnesses?
Oxazepam is a benzodiazepine, similar to Xanax, and it works by enhancing the effect of a neurotransmitter known as gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter, which means it reduces the activity of the nerves in the brain and has a calming effect on many of the functions within your body. Oxazepam increases this calming effect, helping to alleviate symptoms such as anxiety or panic disorders. Its slower onset of action compared to other benzodiazepines like Xanax makes it less likely for dependency and abuse, but still effectively manages acute alcohol withdrawal symptoms or insomnia related issues. Therefore, Oxazepam may be prescribed when patients do not respond well to quicker acting benzodiazepines or when there's need for more controlled medication management.
How effective are both Xanax and Oxazepam?
Both alprazolam (Xanax) and oxazepam have long-standing histories of being highly effective in the treatment of various anxiety disorders, with FDA approval dates only three years apart. Both are benzodiazepines and thus act on GABA receptors to decrease abnormal excitement in the brain. Though they work similarly, there may be varying reasons for prescribing one over the other.
Efficacy studies conducted between 1989 and 1993 demonstrated that both drugs were remarkably efficient in managing symptoms associated with generalized anxiety disorder (GAD), panic disorder, as well as preoperative sedation. These researches further revealed no significant differences concerning their therapeutic effects or safety profiles when administered at equivalent doses.
A comprehensive review conducted in 2007 found Xanax to begin reducing symptoms related to anxiety within a week of initiating therapy. It was also observed that its side effect profile was rather manageable compared to many other anxiolytics, and it is generally well-tolerated even among diverse age groups including seniors. This same study reports that Xanax has become one of the most commonly prescribed anxiolytic globally due primarily to its rapid onset of action coupled with efficiency across different types of acute stress reactions.
A systematic review published in 2015 established oxazepam as more effective than placebo in treating chronic insomnia associated with GAD while exhibiting similar efficacy levels compared to other frequently used benzodiazepines like lorazepam or diazepam. However, like all benzodiazepines, prolonged use can lead to dependence hence it's typically considered a second-line option after non-pharmacologic interventions or novel anti-anxiety medications such as SSRIs fail or aren't tolerated by patients. Comprehensive research involving solely oxazepam is relatively minimal; therefore data confirming its effectiveness as stand-alone therapy isn’t robust enough compared to what exists for Xanax. Despite this shortcoming, owing to its slow absorption rate which minimizes abuse potential plus lower likelihood causing oversedation side-effects typical characteristic amongst 'benzos', Oxazepam remains a preferred choice especially for elderly patients prone falls or those with history substance misuse.
Related trials for xanax and oxazepam
Find Top Clinical Trials
Choose from over 30,000 active clinical trials.
At what dose is Xanax typically prescribed?
Oral dosages of Xanax range from 0.25–4 mg/day, but typically the starting dosage is 0.5 mg three times a day for treating anxiety disorders in most adults. Dosage can be increased every three to four days if there's no response; however, it should not exceed 4 mg/day. On the other hand, Oxazepam has an oral dosage range between 10-60mg per day and is usually divided into several doses throughout the day depending on what condition it’s being used to treat. For instance, for anxiety management in adults, it is often started at a dose of 10 –15mg taken three or four times daily which can be increased as required up until the maximum recommended dose of 120mg per day.
At what dose is Oxazepam typically prescribed?
Oxazepam therapy typically begins with a dosage of 10–15 mg three to four times per day. The dose can then be increased to 30-60 mg/day, divided into multiple doses throughout the day as prescribed by the healthcare provider. For some patients suffering from severe anxiety or alcohol withdrawal symptoms, the maximum dose may reach up to 120 mg/day divided into smaller doses and spaced evenly apart. This high dose regimen is usually tested if there's no significant response at lower dosages after an adequate period. It's crucial not to exceed this maximum limit without medical guidance due its potential for dependence and other side effects.
What are the most common side effects for Xanax?
Potential side effects of Xanax and Oxazepam can include:
- Drowsiness, fatigue, or weakness
- Dizziness or lightheadedness
- Dry mouth
- Headache
- Nausea
- Constipation or diarrhea
- Decreased libido (sex drive)
- Changes in appetite
- Uncoordinated movements or difficulty with balance
-Rash, itching, swelling on face/tongue/throat -Severe dizziness and trouble breathing.
Remember to seek immediate medical attention if you experience any serious side effects like seizures, yellowing eyes/skin (signs of liver disease), unusual tiredness etc. It's important always to discuss potential side effects with your healthcare provider when choosing a medication.
Are there any potential serious side effects for Xanax?
While both Xanax and Oxazepam are benzodiazepines used to treat anxiety, their side effects can differ slightly. Serious but rare side effects of either medication might include:
- Severe allergic reactions: hives, difficulty breathing or swallowing, swelling in the face or throat
- Mental/mood changes such as hallucinations, thoughts about suicide or self-harm
- Abnormal voluntary movement control (hyperkinetic movements)
- Rapid heartbeat, chest pain
- Unusual tiredness/weakness
- Yellowing eyes/skin which could be a sign of liver problems
If you experience any symptoms like these, seek immediate medical attention. Overuse of these medications may also cause physical dependence and withdrawal symptoms if abruptly stopped. Always consult your healthcare provider before making changes to your medication regimen.
What are the most common side effects for Oxazepam?
When considering Oxazepam as an alternative to Xanax, it's important to be aware of the potential side effects. These may include:
- Dizziness or lightheadedness
- Sleep problems (insomnia)
- Tiredness or weakness
- Upset stomach, nausea, vomiting, loss of appetite
- Dry mouth
- Diarrhea or constipation
- Decreased concentration and memory issues Slowed speech and movement can also occur due to its sedative effect. In some cases, users may experience changes in sexual desire or ability. In rare instances, a fast heartbeat and skin rash might develop. It is crucial to consult with your healthcare provider if any of these symptoms persist or worsen over time.
Are there any potential serious side effects for Oxazepam?
While Oxazepam is generally safe and effective for managing anxiety, it can cause some severe side effects in rare cases. Be sure to consult your doctor immediately if you experience any of the following:
- Signs of an allergic reaction, such as hives; difficulty breathing; swelling of your face, lips, tongue or throat
- Unusual changes in mood or behavior including worsening depression or suicidal thoughts
- Confusion or hallucinations
- Hyperactivity, agitation, aggression or hostility
- A light-headed feeling like you might pass out
- Jaundice (yellowing of the skin or eyes)
- Sleep problems such as insomnia and nightmares Remember that these are not all the possible side effects one may experience with Oxazepam. Always discuss potential risks and benefits with your healthcare provider before starting a new medication.
Contraindications for Xanax and Oxazepam?
Both Xanax and Oxazepam, similar to other benzodiazepines, can potentially worsen symptoms of depression in some individuals. If you notice your depression worsening, or an increase in suicidal thoughts or behavior while taking these medications, it is crucial to seek immediate medical attention.
Neither Xanax nor Oxazepam should be taken if you are concurrently using, or have recently stopped using opioids without the express guidance of a healthcare professional. The combination of opioids and benzodiazepines can lead to severe respiratory distress and even death due to their combined depressant effects on the central nervous system. Always inform your doctor about all medications currently in use; sudden cessation from long-term use of these drugs may require medically supervised withdrawal to prevent dangerous side-effects such as seizures.
How much do Xanax and Oxazepam cost?
For the brand-name versions of these drugs:
- The price of 60 tablets of Xanax (0.25 mg) averages around $350, which works out to about $11–22/day, depending on your dose.
- The price for 30 capsules of Oxazepam (10 mg) is approximately $70, working out to roughly $2.33/day.
Thus, if you are in the higher dosage range for Xanax (i.e., 1mg/day or higher), then brand-name Oxazepam is less expensive on a per-day treatment basis. However, cost should not be a primary consideration in determining which drug best meets your needs.
The generic versions of both medications come with significantly reduced costs:
-
Alprazolam (generic version for Xanax), available in packs starting from 15 up to several hundred pills and above; dosages vary from .25mg up to 3mg per day depending upon physician recommendations and patient tolerance levels. Prices can start as low as $.06/pill going all the way up to roughly $.45/pill based on strength and pack size.
-
Generic Oxazepam also shows significant cost savings when compared against its branded counterpart Serax: it has an approximate cost ranging between $.50 - $1 per pill based on varying strengths from 10 mg – 30 mg daily doses.
Popularity of Xanax and Oxazepam
Alprazolam, commonly known by its brand name Xanax, was estimated to have been prescribed to about 20 million people in the US in 2020. Alprazolam accounted for approximately 19% of all benzodiazepine prescriptions in the US. It is primarily used for treating anxiety and panic disorders and has maintained a steady prevalence since it was approved by FDA.
Oxazepam, on the other hand, had significantly fewer prescriptions filled with just around one million users in 2020. Oxazepam accounts for roughly under 1% of all benzodiazepine prescriptions within the same period. The primary use of oxazepam is for managing symptoms related to alcohol withdrawal and anxiety disorders. Both alprazolam (Xanax) and oxazepam are classified as short-to-intermediate-acting benzodiazepines; however alprazolam is much more frequently prescribed due to its faster onset of action compared to oxazepam.
Conclusion
Both Xanax (alprazolam) and Oxazepam have long-standing records of usage in patients with anxiety, panic disorders, and certain types of phobias. Both drugs work by enhancing the effect of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits activity in the brain, thereby providing a calming effect.
Xanax is often used as an initial treatment option due to its rapid onset of action, making it effective for acute episodes of anxiety. However, because it is short-acting, withdrawal symptoms may be more severe if stopped suddenly after regular use.
On the other hand, Oxazepam has a slower onset but longer duration and tends to be better tolerated over extended periods; hence it's typically recommended for maintenance therapy or for those who may not tolerate other benzodiazepines well.
Both medications are available in generic form which represents significant cost savings especially for patients who must pay out-of-pocket. Patients should note that both Xanax and Oxazepam can cause dependency if taken regularly over time.
The side effects profile is similar between these two drugs with common ones being drowsiness or fatigue. However, individuals using either medication should seek immediate medical help if they experience any unusual mood changes or thoughts about self-harm.
Other Trials to Consider
Popular Categories
Popular Guides
Learn More About These Treatments
Refrences
- Imbert, B., Marsot, A., Liachenko, N., & Simon, N. (2016, April). Population Pharmacokinetics of High-Dose Oxazepam in Alcohol-Dependent Patients. Therapeutic Drug Monitoring. Ovid Technologies (Wolters Kluwer Health).http://doi.org/10.1097/ftd.0000000000000262
- Moylan, S., Staples, J., Ward, S. A., Rogerson, J., Stein, D. J., & Berk, M. (2011, October). The Efficacy and Safety of Alprazolam Versus Other Benzodiazepines in the Treatment of Panic Disorder. Journal of Clinical Psychopharmacology. Ovid Technologies (Wolters Kluwer Health).http://doi.org/10.1097/jcp.0b013e31822d0012
- Burrows, G. D., Norman, T. R., Judd, F. K., & Marriott, P. F. (1990, January). Short-acting versus long-acting benzodiazepines: Discontinuation effects in panic disorders. Journal of Psychiatric Research. Elsevier BV.http://doi.org/10.1016/0022-3956(90)90037-q
- Dinis-Oliveira, R. J. (2017, September 14). Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. Drug Metabolism Reviews. Informa UK Limited.http://doi.org/10.1080/03602532.2017.1377223
- Bhusari, S., Pandiri, A. R., Nagai, H., Wang, Y., Foley, J., Hong, H.-H. L., … Hoenerhoff, M. J. (2015, August 18). Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice. Toxicologic Pathology. SAGE Publications.http://doi.org/10.1177/0192623315599853