Augmentin Xr

Urinary Tract Infections, Sinusitis, Gonorrhea + 11 more

Treatment

2 FDA approvals

20 Active Studies for Augmentin Xr

Treatment for

Urinary Tract Infections

What is Augmentin Xr

Amoxicillin

The Generic name of this drug

Treatment Summary

Amoxicillin, also known as BRL-2333, is a type of penicillin medication. It was developed in 1972 and approved by the FDA in 1974. It is similar to penicillin and ampicillin but it produces higher levels of the drug in the bloodstream.

Amoxicillin

is the brand name

image of different drug pills on a surface

Augmentin Xr Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Amoxicillin

1978

1067

Approved as Treatment by the FDA

Amoxicillin, also called Amoxicillin, is approved by the FDA for 2 uses including Duodenal Ulcer and Duodenal ulcer caused by helicobacter pylori .

Duodenal Ulcer

Used to treat Duodenal ulcer caused by helicobacter pylori in combination with Clarithromycin

Duodenal ulcer caused by helicobacter pylori

Used to treat Duodenal ulcer caused by helicobacter pylori in combination with Clarithromycin

Effectiveness

How Augmentin Xr Affects Patients

Amoxicillin works by blocking the proteins that help create the cell walls of bacteria. This means that it is effective for a long time and can be taken twice a day. It is a relatively safe drug, but patients should be aware of the risks of anaphylaxis, C. Diff infections, and drug resistance.

How Augmentin Xr works in the body

Amoxicillin blocks proteins that help bacteria build their cell walls. Without these proteins, bacteria cannot repair or build new cell walls. This leads to the death of the bacteria.

When to interrupt dosage

The prescribed dosage of Augmentin Xr is contingent upon the diagnosed condition, for instance Lower Respiratory Tract Infection (LRTI), Duodenal Ulcer and Stomach Ulcer. The amount of dosage fluctuates as per the technique of delivery (e.g. For suspension - Oral or Oral) noted in the table beneath.

Condition

Dosage

Administration

ear, nose, and throat infections

, 500.0 mg, 875.0 mg, 200.0 mg, 400.0 mg, 200.0 mg/mL, 400.0 mg/mL, 600.0 mg/mL, 250.0 mg, 125.0 mg/mL, 250.0 mg/mL, 125.0 mg, 775.0 mg, 1000.0 mg, 25.0 mg/mL, 50.0 mg/mL, 600.0 mg, 437.5 mg, 2000.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral, Tablet, chewable, Tablet, chewable - Oral, Kit, Suspension - Oral, Capsule, Capsule - Oral, Suspension, Tablet, coated, Tablet, coated - Oral, Tablet - Oral, Tablet, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, For suspension, For suspension - Oral, Granule, for suspension, Granule, for suspension - Oral, Powder, for solution, Powder, for solution - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Capsule; Capsule, delayed release; Kit; Tablet, Capsule; Capsule, delayed release; Kit; Tablet - Oral, Tablet, soluble, Tablet, soluble - Oral, Tablet, for suspension - Oral, Tablet, for suspension, Tablet, extended release - Oral, Tablet, extended release, Kit - Oral, Intravenous, Powder, for solution - Intravenous, Capsule, delayed release, Capsule, delayed release - Oral

Gonorrhea

Sinusitis

Bronchitis

Otitis

ABDIC protocol

Duodenal Ulcer

Bacterial Infections

Urinary Tract Infection (UTI)

Peptic Ulcer With H. Pylori Infection

Community Acquired Pneumonia (CAP)

Urinary Tract Infections

Helicobacter Pylori Infection

Warnings

Augmentin Xr has six contraindications, and it must not be used in combination with any of the conditions specified in the table below.

Augmentin Xr Contraindications

Condition

Risk Level

Notes

Liver Dysfunction

Do Not Combine

Pulse Frequency

Do Not Combine

Jaundice, Obstructive

Do Not Combine

Jaundice, Obstructive

Do Not Combine

Liver Dysfunction

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Amoxicillin may interact with Pulse Frequency

There are 20 known major drug interactions with Augmentin Xr.

Common Augmentin Xr Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Amoxicillin.

Aclidinium

Minor

Amoxicillin may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Amoxicillin may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Albutrepenonacog alfa

Minor

Amoxicillin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Allylestrenol

Minor

Amoxicillin may decrease the excretion rate of Allylestrenol which could result in a higher serum level.

Augmentin Xr Toxicity & Overdose Risk

Overdosing on amikacin can cause symptoms such as blood in the urine, low urine output, abdominal pain, kidney failure, vomiting, diarrhea, rash, increased energy, and drowsiness. Treatment for an overdose includes supportive care and may include inducing vomiting or dialysis.

image of a doctor in a lab doing drug, clinical research

Augmentin Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Augmentin Xr?

A total of 60 active clinical trials are being conducted to investigate the potential of Augmentin Xr for treating Urinary Tract Infections, ENT infections and Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Bacterial Infections

0 Actively Recruiting

Urinary Tract Infections

0 Actively Recruiting

Duodenal Ulcer

0 Actively Recruiting

Bronchitis

2 Actively Recruiting

Not Applicable

ABDIC protocol

0 Actively Recruiting

ear, nose, and throat infections

0 Actively Recruiting

Community Acquired Pneumonia (CAP)

5 Actively Recruiting

Not Applicable, Phase 1, Phase 3

Sinusitis

2 Actively Recruiting

Not Applicable

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Peptic Ulcer With H. Pylori Infection

0 Actively Recruiting

Urinary Tract Infections

7 Actively Recruiting

Not Applicable, Phase 4

Gonorrhea

0 Actively Recruiting

Urinary Tract Infection (UTI)

6 Actively Recruiting

Phase 1, Phase 3, Phase 4, Phase 2

Otitis

3 Actively Recruiting

Not Applicable

Augmentin Xr Reviews: What are patients saying about Augmentin Xr?

3.7

Patient Review

3/15/2013

Augmentin Xr for Severe Sinusitis caused by Haemophilus Influenzae

This medication helped me with my sinus infection, but unfortunately also caused diarrhea. I had terrible stomach pains for two days, and then the diarrhea started. It's now been three days and I think I'm going to stop taking the medication.

3.7

Patient Review

3/10/2013

Augmentin Xr for Acute Bacterial Infection of the Sinuses

The pills are unfortunately very large and difficult to swallow.

3.7

Patient Review

8/21/2010

Augmentin Xr for Severe Sinusitis caused by Haemophilus Influenzae

3.7

Patient Review

5/20/2011

Augmentin Xr for Acute Bacterial Infection of the Sinuses

I felt nauseous and exhausted after taking this medication, but it did clear up my sinuses.

3.7

Patient Review

2/18/2013

Augmentin Xr for Acute Bacterial Infection of the Sinuses

On day five of the medication, I started experiencing loose stools and nausea. It is now day six, and my stomach feels like I am coming down with a stomach bug. Two more days left to finish the dose.

3.3

Patient Review

6/8/2011

Augmentin Xr for Acute Sinus Infection caused by Klebsiella Pneumoniae Bacteria

I am taking this medication 2 pills twice a day. I have had bad gas but other than that no problem. I am taking it for a sinus infection. I hope the treatment works.

Patient Review

6/20/2013

Augmentin Xr for Acute Bacterial Infection of the Sinuses

I experienced some bad diarrhea after taking this medication, which lasted longer than the recommended duration. I also felt dizzy and, now, three days after my last pill, I have blisters in my mouth?

2.7

Patient Review

3/27/2015

Augmentin Xr for Acute Bacterial Infection of the Sinuses

I started taking this medication for a sinus infection and have experienced severe stomach pain, nausea, and diarrhea since the first day. I take it with food but still experience issues. The pain has even wake me up at night. I reported these problems to my nurse on the sixth day but haven't heard back yet.

1.7

Patient Review

1/20/2013

Augmentin Xr for Acute Bacterial Infection of the Sinuses

I was on a 10-day course of this medication for sinusitis, otitis media, and pharyngitis. However, on day four my tongue and gums started swelling up painfully and the area became discolored. I called my doctor and they told me to stop taking the medication immediately. While it did help with the infections, the side effects were not worth it. I've been off the drug for four days now and I'm still experiencing pain and difficulty eating.

1.3

Patient Review

11/11/2012

Augmentin Xr for Severe Sinusitis caused by Haemophilus Influenzae

I started taking this medication for my sinus infection and, within days, I developed a terrible stomachache that has only gotten worse. Additionally, I've had a pounding headache since starting the antibiotic which has only gotten worse. My cough has improved but overall I feel much worse.

1.3

Patient Review

4/6/2019

Augmentin Xr for Severe Sinusitis caused by Streptococcus Pneumoniae

I was given this drug for strep throat. My strep throat symptoms cleared up within a day. But three hours after starting the antibiotics I started having diarrhea. The diarrhea got so bad I experienced 22 episodes in 24 hours before finally calling my doctor and stopping the medication.

Patient Review

3/26/2013

Augmentin Xr for Acute Bacterial Infection of the Sinuses

I do not recommend this drug. I have seen it lead to death firsthand.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about augmentin xr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the difference between Augmentin and Augmentin XR?

"This is because AUGMENTIN XR contains a lower dose of clavulanic acid than the other AUGMENTIN tablets. The Extended Release Tablet also provides a longer duration of amoxicillin concentrations in the blood than the immediate-release Tablets."

Answered by AI

What is Augmentin XR used for?

"It will not work for viral infections (such as common cold, flu).

The antibiotic Amoxicillin/clavulanic acid is a combination penicillin-type antibiotic used to treat bacterial infections. It works by stopping the growth of bacteria. This antibiotic can only treat bacterial infections and won't work on viral infections like the common cold or flu."

Answered by AI

Is Augmentin the strongest antibiotic?

"Amoxicillin is an antibiotic. It is used to treat infections. Augmentin is an antibiotic. It contains amoxicillin and clavulanic acid. Augmentin works against more types of bacteria than amoxicillin alone. In this regard, it could be considered stronger than amoxicillin."

Answered by AI

Clinical Trials for Augmentin Xr

Image of Children's of Alabama in Birmingham, United States.

Antibiotic Duration for Infections in Children

60 - 17

All Sexes

Birmingham, AL

Infections like pneumonia, skin and soft tissue infection (also called SSTI or cellulitis), and urinary tract infections (UTI) are some of the most common reasons children get admitted to the hospital. All three of these conditions require antibiotics for treatment. Although antibiotics are needed to treat the infection and help children feel better, taking them longer than needed can negatively impact children and their families. Negative impacts include things like the burdens of taking more medications and medication side effects. There are guidelines (instructions) from expert medical organizations that suggest the number of days children need antibiotics, but they give a wide range (between 5 and 14 days). Unfortunately, these guidelines are not based on high-quality studies. National data suggests that doctors often choose on the higher end of this range when writing prescriptions for children in the hospital. Our three caregiver co-investigators, other parents of hospitalized children, doctors, other care providers, and researchers, all believe that additional study is needed to determine the best length of antibiotic treatment that weighs both the benefits and harms of antibiotics. The goal of our study is to understand if 5 total days of antibiotic treatment compared to 10 total days of antibiotic treatment is better for children who have been in the hospital for pneumonia, SSTI, or UTI. We will study this question through a randomized control trial. In other words, half of the children will receive 5-days of antibiotics and the other half will receive 10-days of antibiotics. Children in this study (and their caregivers) will not know how many days of antibiotics they will receive to cure their infection because some children will take a placebo (or a pill without antibiotics in it). Only the pharmacy will know if a child is getting antibiotic or placebo (for days 6-10 of treatment). During the first phase of the trial (feasibility phase), 4 hospitals will enroll children in the study. We plan on enrolling 50 patients during this phase. We are starting with just 4 hospitals, so our study team can create and update our study plans if needed. We will closely review information about how many patients and families agree to participate, and if they have any trouble completing any part of the study. We will also interview families to understand the choice to participate in the study, the choice not to participate in the study, and what it is like to be in the study. During the second study phase, we will enroll 1150 more patients across all 11 hospitals. Families will complete short, daily surveys until the 15th day after they started antibiotics, then a larger survey at day 15, at day 20, and at day 30. These surveys will ask about the child's symptoms and recovery from their illness, how the antibiotics are making them feel, and if they had to go back to their doctor, emergency room, or hospital. The answers to these questions will be combined to measure how well the child did, balancing feeling better and having bad effects from the antibiotics. We will use mathematical tests to determine which antibiotic duration is better for treating these illnesses. We will complete other mathematical tests to see if all children should receive the same length of antibiotics or if certain children should be prescribed shorter courses and others longer courses.

Phase 4

Waitlist Available

Drug

Children's of Alabama (+9 Sites)

Sunitha V Kaiser, MD, MSc

Image of Baylor College of Medicine in Houston, United States.

Educational Tool for Urinary Tract Infections

18+

All Sexes

Houston, TX

Urine culture is the most common microbiological test in the outpatient setting in the United States. Unfortunately, contamination during collection is prevalent and undermines test accuracy, leading to incorrect diagnosis, unnecessary treatment, wasted laboratory resources, and inflated costs. Unnecessary antibiotic treatment increases the risk of developing antimicrobial resistance, one of the most serious threats to patients and public health. The goal of this clinical trial is to test whether a bilingual (English and Spanish) educational intervention, an animated video and pictorial flyer, can reduce urine culture contamination and associated inappropriate antibiotic use in adult patients visiting safety-net primary care clinics. The main questions it aims to answer are: 1. Does providing patients with a bilingual educational intervention reduce urine culture contamination rates? 2. Does the intervention lead to fewer unnecessary urinary antibiotic prescriptions? 3. Does providing patients with a bilingual educational intervention reduce contaminated urinalyses? Researchers will compare patients randomized to receive the educational intervention (video and flyer) to those receiving usual care to see if the intervention improves urine collection accuracy and reduces inappropriate antibiotic use. Participants will watch a short, animated video with step-by-step instructions for proper midstream clean-catch urine (MSCC) collection, receive a pictorial flyer (with stills from the video) reinforcing the instructions, and provide a urine sample for culture. Hypothesis: patients who receive the educational intervention will have: lower urine culture contamination rates (primary outcome), fewer urinary antibiotic prescriptions (secondary outcome), and fewer contaminated urinalyses (secondary outcome). The objectives are to (1) develop educational tools: Create an animated video and pictorial flyer with step-by-step urine collection instructions for women and men, developed through an iterative, stakeholder-engaged process, (2) assess acceptability: Use mixed methods (quantitative surveys and qualitative interviews) to evaluate and refine the tools for usability and cultural/linguistic appropriateness, and (3) test effectiveness: Conduct a randomized controlled trial to assess the intervention's impact on urine contamination rates, antibiotic prescribing, and patient satisfaction.

Waitlist Available

Has No Placebo

Baylor College of Medicine

Larissa Grigoryan, MD, PhD