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What is Clomipramine Hydrochloride
ClomipramineThe Generic name of this drug
Treatment SummaryClomipramine is a tricyclic antidepressant (TCA) used to treat depression and other mental health conditions. It works by increasing the activity of neurotransmitters serotonin and norepinephrine in the brain to improve mood. Common side effects include sedation, blurred vision, dry mouth, constipation, and urinary retention. Clomipramine is also used to treat obsessive-compulsive disorder, panic disorder, chronic pain, cataplexy, trichotillomania, stuttering, premature ejaculation, and premenstrual syndrome. It is absorbed quickly from the gut and metabolized in
Anafranilis the brand name
Clomipramine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Anafranil
Clomipramine
1989
104
Approved as Treatment by the FDA
Clomipramine, also called Anafranil, is approved by the FDA for 1 uses like Obsessive-Compulsive Disorder .Obsessive-Compulsive Disorder
Helps manage Obsessive Compulsive Disorder (OCD)
Effectiveness
How Clomipramine Hydrochloride Affects PatientsClomipramine is an antidepressant medication which works by blocking certain chemicals in the brain that control mood. It usually takes around two weeks for people's mood to improve after taking this drug. It is thought that clomipramine changes how receptors in the brain respond to other chemicals, which leads to increased production of a certain chemical that affects mood. Clomipramine is also used to treat certain types of pain, especially those caused by nerve damage.
How Clomipramine Hydrochloride works in the bodyClomipramine is a drug that affects the reuptake of serotonin in the brain. It also blocks certain receptors and sodium channels, which may help to reduce chronic pain, especially neuropathic pain.
When to interrupt dosage
The proposed dose of Clomipramine Hydrochloride is based on the diagnosed disorder, such as Obsessive-Compulsive Disorder, Depression and Panic Disorder. The measure of dosage is contingent on the method of administration listed in the table below.Condition
Dosage
Administration
Obsessive-Compulsive Disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, Tablet - Oral
Panic Disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, Tablet - Oral
Depression
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, Tablet - Oral
Warnings
Clomipramine Hydrochloride ContraindicationsCondition
Risk Level
Notes
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Clomipramine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Anagrelide.
Apixaban
Major
The metabolism of Apixaban can be decreased when combined with Clomipramine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Asenapine.
Clomipramine Hydrochloride Toxicity & Overdose RiskAnafranil overdose can cause a range of symptoms, from mild to severe, which depend on the amount taken, age of the person, and how long ago the drug was taken. Severe reactions include changes in heart rhythm, very low blood pressure, seizures, and loss of consciousness. In some cases, death has occurred due to an Anafranil overdose. Other side effects include drowsiness, blurry vision, dry mouth, constipation, difficulty urinating, dizziness when standing up, rapid heartbeat, high blood pressure, heart failure, memory problems and confusion, and mood swings in those with bipolar disorder. Withdraw
Clomipramine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Clomipramine Hydrochloride?
634 active clinical trials are currently assessing the potential of Clomipramine Hydrochloride to alleviate Panic Disorder, Obsessive-Compulsive Disorder and Depression.Condition
Clinical Trials
Trial Phases
Obsessive-Compulsive Disorder
16 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1
Panic Disorder
15 Actively Recruiting
Not Applicable, Phase 2
Depression
364 Actively Recruiting
Phase 1, Phase 2, Early Phase 1, Not Applicable, Phase 4, Phase 3
Clomipramine Hydrochloride Reviews: What are patients saying about Clomipramine Hydrochloride?
5Patient Review
2/3/2017 This drug has done wonders for my OCD. It's helped me more than any other SRIs I've tried, to the point where I only have mild symptoms that I can manage. The side effects are a bit of a nuisance (dry mouth and constipation), but they're worth it in light of the benefits I've experienced.
5Patient Review
6/24/2022 This treatment is much more effective than an SSRI.
5Patient Review
2/6/2014 I've been taking 100mg per day for about a month now with no negative side effects. This medication helped me almost immediately with my OCD by curbing my excessive counting behavior.
4.7Patient Review
4/4/2017 I've found this to be the best medication for intrusive thoughts, anxiety, and panic. That being said, it can have some nasty side effects that one should be aware of before taking it. Please speak with a professional to see if this is the right drug for you.
4.7Patient Review
9/18/2015 It took a little while for this to start working, but it was very effective in treating my OCD. I also saw a massive improvement in my insomnia and panic attacks.
4.3Patient Review
10/9/2017 I've been taking 100mg of clomipramine every day, and it has really helped me sleep better. The only downside is that I developed ringing in my ears, which may be a side effect of the drug.
4.3Patient Review
11/1/2022 This medication saved me. I had been struggling with chronic IBS and OCD for years, trying all sorts of different treatments to no avail. But as soon as I started taking Clomiprine, everything changed. Within a week my diarrhea and unwanted thoughts were gone. If you're struggling with anything similar, I urge you to give this medication a try.
4.3Patient Review
4/3/2014 I was struggling with some serious mental health issues, and this medication really turned things around for me. I felt a difference from the very first day, and now my intrusive thoughts are gone.
4.3Patient Review
10/6/2018 Despite the dry mouth and constipation, this medication is worth it because it helps me stay balanced and employed.
3.3Patient Review
2/16/2020 I've been using this medication for a couple years now. It's helped me feel better, but I have noticed some negative side effects like memory problems and an irregular heartbeat.
3Patient Review
3/21/2013 I found that clomipramine was more effective than alprazolam for me, but everyone is different.
1.7Patient Review
5/4/2017 I have severe OCD and this medication, which my doctor just raised the dosage of last week, did not help alleviate my symptoms at all. In addition to that, it caused some very unpleasant side effects like a fast heartbeat, muscle pain, and anorexia.
1.7Patient Review
3/23/2020 Made me feel very unstable and my thoughts were racing while I was on it.
1.7Patient Review
10/8/2012 I think this medication led to me overeating and gaining weight.
1Patient Review
7/3/2014 Unfortunately, this drug did not work well for me. I had heart palpitations on a small dosage of 10mg and it only got worse when the doctor increased my dosage to 20mg. I felt incredibly tired and had no appetite while taking this medication, and now that I'm off of it I feel like I have the flu.
1Patient Review
5/17/2017 Unfortunately, this medicine exacerbated my bipolar and OCD symptoms. I would go for a couple days without sleep, then sleep for a couple days in a row. It was constant twitching in my legs and feet that i didn't have before i started this medicine
Patient Q&A Section about clomipramine hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is clomipramine a strong antidepressant?
"Although Clomipramine is most commonly used as a treatment for obsessive-compulsive disorder, it is also an effective antidepressant. It works by affecting certain receptors in the brain, as shown in the table below."
Answered by AI
What are the most common side effects of clomipramine?
"The following side effects may occur when taking clomipramine: feeling dizzy or tired, dry mouth, trouble Line, upset stomach, nausea or vomiting, changes in appetite or weight, flushed skin, sweating, tiredness, or blurred vision. Symptoms of anxiety may get worse when you first start taking clomipramine."
Answered by AI
How does clomipramine make you feel?
"Clomipramine may make you feel sleepy, so your doctor may start you on a small dose. They may then gradually increase your dose as your body gets used to it. Clomipramine is usually taken once a day at bedtime, but it can also be taken in smaller doses two to three times a day."
Answered by AI
What is clomipramine prescribed for?
"It affects chemicals in the brain that may become unbalanced and cause OCD.
Clomipramine is used to treat obsessive compulsive disorder (OCD). OCD is a nervous condition wherein a person has recurring thoughts or ideas or does repetitive things because they are anxious. Clomipramine is a tricyclic antidepressant (TCA). It affects chemicals in the brain that may become unbalanced, which can lead to OCD."
Answered by AI