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What is Belbuca
BuprenorphineThe Generic name of this drug
Treatment SummaryBuprenorphine is a medication used to treat severe pain and opioid addiction. It is sold under the brand name Suboxone and is formulated with naloxone, a drug that blocks the effects of opioids if injected. Buprenorphine works by binding to the opioid receptors in the brain, but it has weaker effects than other opioids. This makes it less likely to cause side effects, such as sedation, respiratory depression, and overdose. Buprenorphine is also used in opioid substitution therapy to help people with opioid addiction stop using illicit drugs and reduce their risk of contracting HIV and hepatitis C.
Buprenexis the brand name
Belbuca Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Buprenex
Buprenorphine
1985
261
Approved as Treatment by the FDA
Buprenorphine, commonly known as Buprenex, is approved by the FDA for 1 uses which include Opioid-Related Disorders .Opioid-Related Disorders
Used to treat Opioid Dependence in combination with Naloxone
Effectiveness
How Belbuca Affects PatientsBuprenorphine is an opioid pain reliever that works by binding to receptors in the brain and spinal cord. It can cause feelings of euphoria, drowsiness, decreased cough reflex, and constricted pupils. It can be addictive and can lead to physical dependence if taken for a long time. If stopped abruptly, withdrawal symptoms such as body aches, trouble sleeping, and stomach cramps can occur. It can also cause life-threatening respiratory depression and overdose, especially when taken with other CNS depressants like alcohol. It can lead to constipation, and its long-term use can affect the hormones that control sexual function and
How Belbuca works in the bodyBuprenorphine is a drug that acts on opioid receptors in the body. It binds to the mu-opioid receptor and blocks the kappa-opioid receptor. It binds to the mu-opioid receptor much more strongly than other opioids like heroin, oxycodone, or methadone, but it has less of an effect on the body than those drugs. This means that when you take buprenorphine, you don't get as much pain relief but you also don't experience as strong of side effects, like respiratory depression. It also means that people don't get as much of a
When to interrupt dosage
The prescribed measure of Belbuca is contingent upon the diagnosed condition, such as Pain, Pain and Opioid Dependence. The dosage fluctuates as per the method of delivery (e.g. Tablet - Oral or Sublingual) featured in the table underneath.Condition
Dosage
Administration
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Opioid-Related Disorders
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Pain
0.324 mg/mL, , 0.3 mg/mL, 8.0 mg, 0.01 mg/hour, 0.02 mg/hour, 0.005 mg/hour, 2.0 mg, 80.0 mg, 16.0 mg, 0.075 mg, 0.15 mg, 0.3 mg, 0.45 mg, 0.6 mg, 0.75 mg, 0.9 mg, 0.0075 mg/hour, 0.015 mg/hour, 12.0 mg, 4.0 mg, 1.4 mg, 11.4 mg, 2.9 mg, 5.7 mg, 8.6 mg, 0.7 mg, 4.2 mg, 2.1 mg, 6.3 mg, 0.2 mg, 300.0 mg, 100.0 mg, 0.0025 mg/hour, 74.2 mg, 96.0 mg, 24.0 mg, 128.0 mg, 64.0 mg, 32.0 mg, 300.0 mg/mL, 1000.0 mg/mL, 7.5 mg/hour, 15.0 mg/hour, 20.0 mg/hour, 5.0 mg/hour, 10.0 mg/hour
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Sublingual, Tablet, Tablet - Sublingual, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Oral, Tablet - Oral, Film, soluble, Film, soluble - Sublingual, Patch, Patch - Transdermal, Subcutaneous, Implant, Implant - Subcutaneous, Buccal, Film - Buccal, Film, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Film, soluble - Buccal, Pill - Sublingual, Pill, Solution, Solution - Subcutaneous, Buccal; Sublingual, Film, soluble - Buccal; Sublingual, Film - Buccal; Sublingual, Solution, gel forming, extended release, Solution, gel forming, extended release - Subcutaneous
Warnings
Belbuca has twenty-two contraindications, and it should not be consumed in conjunction with any of the conditions presented in the following table.Belbuca ContraindicationsCondition
Risk Level
Notes
Alcohol Withdrawal Delirium
Do Not Combine
Asthma
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
suspected gastrointestinal obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Asthma
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Head
Do Not Combine
ethanol
Do Not Combine
Stomatitis
Do Not Combine
Abdomen
Do Not Combine
severe CNS depression
Do Not Combine
opioid naive
Do Not Combine
Myasthenia Gravis
Do Not Combine
Epilepsy
Do Not Combine
Hypocalcemia
Do Not Combine
Hypokalemia
Do Not Combine
Hypomagnesemia
Do Not Combine
Mental Depression
Do Not Combine
Cerebrospinal Fluid
Do Not Combine
Long QT Syndrome
Do Not Combine
Common Belbuca Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Buprenorphine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Buprenorphine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Buprenorphine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Buprenorphine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Buprenorphine.
Belbuca Toxicity & Overdose RiskAn overdose of Morphine can cause constricted pupils, drowsiness, low blood pressure, difficulty breathing, and even death.
Belbuca Novel Uses: Which Conditions Have a Clinical Trial Featuring Belbuca?
Currently, 21 active trials are assessing the possibility of using Belbuca to address Opioid Dependence, Pain and Nociceptive Pain.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Opioid-Related Disorders
0 Actively Recruiting
Belbuca Reviews: What are patients saying about Belbuca?
5Patient Review
1/2/2022 This treatment really helped me get my life back to normal by gradually relieving my back pain. At first, it was a bit weird to put in my mouth but you get used to it. It's best if you don't drink liquids or eat for a while after putting it in. I haven't tried other medications so I can't compare it to oxycodone or morphine, but this worked well for me.
4.7Patient Review
5/10/2022 I was able to sit in a chair for the first time pain-free in three years, thanks to this medicine. I take 40mg of hydrocodone and 2 150mcg doses of belbuca every day. I feel like this has truly changed my life for the better and given me back some quality of life.
4Patient Review
4/13/2022 I hadn't been able to turn my head to the right for two months due to T2 T3 T4 disc generation, and I have a spine stimulator installed for my L5 disc that protruded into my nerves. Within 5 minutes of putting the strip in my mouth, I could turn my head again. I still have discomfort but maybe the dose just needs increased.
1.7Patient Review
3/14/2022 I took this for over a year and found it to be completely ineffective. I actually had more success when I stopped taking Percocet and only relied on Belbuca 450.
1.3Patient Review
11/17/2021 I can't get this to stay on my cheek long enough to actually work, and it's way too expensive. I've tried a similar patch before but had issues with the adhesive giving me rashes.
1.3Patient Review
6/15/2022 This treatment didn't work very well for me. It only slightly eased my pain, and now I'm dealing with a whole host of other dental problems.
1.3Patient Review
10/17/2021 This medication did not help relieve my pain or increase my mobility at all. I took it as prescribed, but felt that it only worked against my other hydrocodone medication. In my opinion, this drug is good for people who are in minimal pain or exaggerate their level of discomfort.
1Patient Review
9/2/2021 Belbuca was ineffective and actually caused me new problems. My teeth started hurting and feeling weak while using this treatment, and the patch itself would often drift onto my teeth. Additionally, you can't move around much with the patch in your mouth or else it will roll up and stop sticking to your cheek. Overall, I found the pain relief to be minimal and short-acting, even when I doubled the dose. In conclusion: horrible delivery system, negligible results.
1Patient Review
9/2/2021 Not only was this treatment ineffective for me, but it also made my teeth hurt and feel weak. I was unable to function normally and had to stay in bed most of the time just to reduce the pain. The delivery system is also very difficult and ridiculous.
Patient Q&A Section about belbuca
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class of drug is BELBUCA?
"BELBUCA contains buprenorphine, which is a Schedule III controlled substance. As an opioid, BELBUCA users are at risk of addiction, abuse, and misuse."
Answered by AI
Is BELBUCA a strong drug?
"BELBUCA is a strong prescription pain medicine that contains an opioid (narcotic) that is used to manage severe pain that requires continuous, around-the-clock treatment with an opioid. Other pain treatments, such as non-opioid pain medicines or immediate-release opioid medications, are not effective for this type of pain."
Answered by AI
What is BELBUCA and how does it work?
"BELBUCA is a small, thin square film that dissolves completely, allowing the medicine buprenorphine to be absorbed more efficiently. It has a mild peppermint taste."
Answered by AI