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Corticosteroid

Steroid Injection for Chronic Cough

Phase < 1
Waitlist Available
Led By Lauren Howser
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age ≥ 18
History consistent with chronic unexplained or refractory cough
Must not have
Prior superior laryngeal nerve injection
Patients on ACE inhibitors or Angiotensin II receptor blockers (ARBs)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 weeks

Summary

This trial aims to determine if injecting steroids into the muscle can help treat unexplained chronic cough. Patients will receive either a steroid injection or a placebo injection in their muscle, and their outcomes will be compared

Who is the study for?
This trial is for individuals with unexplained chronic cough, possibly due to conditions like laryngitis or chronic bronchitis. Participants should not have received similar treatments recently and must be able to attend all study visits. Specific inclusion and exclusion criteria details are not provided.
What is being tested?
The trial tests if steroid injections into the muscle (Triamcinolone Acetonide) are more effective than placebo (saline injection) in treating chronic cough. It's a controlled study where patients don't know which treatment they get, but researchers do.
What are the potential side effects?
Possible side effects may include pain at the injection site, allergic reactions to steroids, increased risk of infections, mood swings, high blood sugar levels, and other steroid-related issues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I have a long-term cough that treatments haven't helped.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had an injection in the nerve of my voice box before.
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I am taking ACE inhibitors or ARBs for my blood pressure.
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My lung function tests have been abnormal since my cough began.
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My diabetes is not under control (A1c > 7%).
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I have sleep apnea that is not well-managed.
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I have severe heartburn that isn't managed by medication.
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I am taking medication for a long-term cough.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Leicester Cough Questionnaire
Secondary study objectives
Dichotomous yes/no to symptom improvement
Visual Analog Scale

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: SteroidExperimental Treatment1 Intervention
Triamcinolone injection into deltoid (arm)
Group II: PlaceboPlacebo Group1 Intervention
Placebo injection into deltoid (arm)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Triamcinolone Acetonide Injectable Suspension
2007
Completed Phase 3
~60

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
968 Previous Clinical Trials
7,399,660 Total Patients Enrolled
Lauren HowserPrincipal InvestigatorMedical University of South Carolina
~27 spots leftby May 2025
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