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Transcranial Magnetic Stimulation for Healthy Volunteers

Phase < 1
Waitlist Available
Led By Thorsten Kahnt, Ph.D.
Research Sponsored by National Institute on Drug Abuse (NIDA)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Must not have
Daily smoking (at least four continuous weeks) within the past 12 months
Predisposition to seizures (e.g., first-degree family history of potentially hereditary epilepsy, etc.)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after each intervention
Awards & highlights

Summary

This trial aims to test a technique called transcranial magnetic stimulation (TMS) in healthy volunteers aged 18 to 45 years. Participants will undergo up to 5 different experiments involving TMS

Who is the study for?
This trial is for healthy, right-handed individuals aged 18 to 45. Participants will engage in up to five experiments involving transcranial magnetic stimulation (TMS) and functional MRI scans while performing various tasks.
What is being tested?
The study tests intermittent and continuous Theta Burst Stimulation (iTBS/cTBS), plus a sham version, using TMS on healthy volunteers. The goal is to understand how TMS affects brain activity related to learning and decision-making.
What are the potential side effects?
Participants may experience sensations like tapping or pulling under the coil during TMS, muscle twitches in the face, neck, arm, or leg muscles, and they might be asked to tense certain muscles.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have smoked daily for at least a month in the past year.
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I have a family history that might increase my risk of seizures.
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I have severe vision problems that affect my daily activities.
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I am fluent in English.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after each intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and after each intervention for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Task Performance

Trial Design

5Treatment groups
Experimental Treatment
Group I: Experiment 5Experimental Treatment2 Interventions
Healthy volunteers in experiment 5
Group II: Experiment 4Experimental Treatment1 Intervention
Healthy volunteers in experiment 4
Group III: Experiment 3Experimental Treatment2 Interventions
Healthy volunteers in experiment 3
Group IV: Experiment 2Experimental Treatment3 Interventions
Healthy volunteers in experiment 2
Group V: Experiment 1Experimental Treatment3 Interventions
Healthy volunteers in experiment 1

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Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)Lead Sponsor
2,543 Previous Clinical Trials
3,248,776 Total Patients Enrolled
2 Trials studying Normal Physiology
970 Patients Enrolled for Normal Physiology
Thorsten Kahnt, Ph.D.Principal InvestigatorNational Institute on Drug Abuse (NIDA)
2 Previous Clinical Trials
700 Total Patients Enrolled
1 Trials studying Normal Physiology
550 Patients Enrolled for Normal Physiology
~400 spots leftby Nov 2044
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