Ketamine for Postpartum Depression
(PREPARE-2 Trial)
Trial Summary
What is the purpose of this trial?
The purpose of this study is to identify pharmacokinetics of postpartum ketamine infusion. This study will assess ketamine kinetics and metabolism in this setting. Ketamine is expected to exert different kinetics during the physiologic state of post-pregnancy. The goal in conducting this study is to better understand the pharmacokinetics and pharmacodynamics of postpartum ketamine infusion. A secondary goal is to compare these kinetics to reproductive age matched controls and to assess sex differences in ketamine pharmacokinetics. The peripartum group of this study will receive ketamine after cesarean delivery, while the control group will consist of non-pregnant female subjects and male subjects receiving the same infusion protocol.
Eligibility Criteria
This trial is for women who have just given birth by cesarean section and are experiencing postpartum depression or pain. It aims to understand how ketamine, used here for its potential mood-lifting and pain-relieving effects, behaves in the body after pregnancy. Non-pregnant women and men will serve as controls to compare results.Inclusion Criteria
Treatment Details
Interventions
- Ketamine (NMDA Receptor Antagonist)