THC for Type 2 Diabetes

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: University of California, San Diego

Trial Summary

What is the purpose of this trial?This study will examine the effects THC has on Glucose Metabolism and Endothelial Functioning in participants with Type 2 Diabetes. The participants will complete blood tests and tests to measure energy expenditure, CVD risks, and glucose metabolism. These tests will be performed prior to start of treatment and again after 2-weeks of treatment with the THC or placebo.

Eligibility Criteria

Adults aged 21-70 with Type 2 Diabetes, a BMI over 25 kg/m2, and stable diabetes medication for at least 3 months can join. They must not use tobacco or THC products recently, have no significant illnesses or heart issues, and agree to contraception if of childbearing potential.

Inclusion Criteria

I am willing to use contraception throughout the study.

I agree to use two forms of birth control during the study.

I have been on stable diabetes medication for over 3 months.

+6 more

Exclusion Criteria

You have experienced serious problems from using cannabis, such as extreme anxiety, paranoia, or severe changes in heart rate or blood pressure.

I have a history of conditions like seizures or head injuries that could make me more likely to have seizures.

I am willing and able to follow the study rules and attend all appointments.

+10 more

Participant Groups

The trial is testing the effects of THC on glucose metabolism in Type 2 Diabetes patients compared to a placebo. Participants will undergo blood tests and other assessments before and after two weeks of treatment to measure changes.

2Treatment groups

Active Control

Placebo Group

Group I: Active THCActive Control2 Interventions

Daily, inhaled, flexible dose of cannabis product with THC.

Group II: Placebo CannabisPlacebo Group2 Interventions

Daily, inhaled, flexible dose of cannabis product without THC.