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Machine Perfusion

Liver Perfusion for Liver Transplant

N/A
Waitlist Available
Led By Cristiano Quintini, MD
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months post-transplantation
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing whether a new method of preserving livers (NMP) before transplantation is better than the current standard (cold storage). NMP has been used before with promising results. If NMP is found to be better than cold storage, it would improve donor pool and outcomes for high risk ECD liver transplants.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months post-transplantation
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months post-transplantation for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
The rate of primary non-function
Secondary study objectives
The rate of Early Allograft Dysfunction post-transplantation
graft survival
peak Alanine Aminotransferase (ALT) in the first 7 days post-transplantation
+2 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Normothermic Liver perfusionExperimental Treatment1 Intervention
This group has the liver grafts preserved using the Normothermic Liver perfusion Device

Find a Location

Who is running the clinical trial?

The Cleveland ClinicLead Sponsor
1,056 Previous Clinical Trials
1,371,587 Total Patients Enrolled
Cristiano Quintini, MDPrincipal Investigator - The Cleveland Clinic
Cleveland Clinic Hospital
University Di Bologna (Medical School)
3 Previous Clinical Trials
53 Total Patients Enrolled
Koji Hashimoto, MD, PhDPrincipal InvestigatorThe Cleveland Clinic
2 Previous Clinical Trials
28 Total Patients Enrolled

Media Library

Normothermic Liver Perfusion (Machine Perfusion) Clinical Trial Eligibility Overview. Trial Name: NCT03456284 — N/A
Liver Transplant Research Study Groups: Normothermic Liver perfusion
Liver Transplant Clinical Trial 2023: Normothermic Liver Perfusion Highlights & Side Effects. Trial Name: NCT03456284 — N/A
Normothermic Liver Perfusion (Machine Perfusion) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03456284 — N/A
~5 spots leftby Dec 2025
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