Stem Cell Therapy
Stem Cell Transplantation + Arthroscopy for Knee Osteoarthritis
This trial is comparing two different treatments for patients with mild to moderate osteoarthritis. One treatment involves harvesting fat from the patient and transplanting stem cells from that fat, in addition to standard arthroscopic procedures. The other treatment is just the standard arthroscopic procedures without the stem cell transplant.
Neurotoxin
Resiniferatoxin +1 More for Osteoarthritis
This trial is testing different doses of two drugs, RTX and Zilretta, to see which is best at reducing knee pain from osteoarthritis. The study involves people who have moderate to severe knee pain. The drugs are injected directly into the knee joint to help relieve pain. RTX is derived from cactus-like plants, and Zilretta is designed to provide long-lasting pain relief.
Procedure
PPS Injections for Knee Osteoarthritis
This trial is testing the effectiveness of a drug called pentosan polysulfate sodium (PPS) for treating knee pain caused by osteoarthritis. The study will last up to 80 weeks, and participants will receive either PPS injections or placebo injections.
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Trials for Osteoarthritis Patients
Corticosteroid
Methylprednisolone for Knee Arthritis
"This trial is testing if a specific steroid medication, methylprednisolone, can improve patient outcomes after knee replacement surgery. The steroid will be given in decreasing doses over time to see if it helps
Selective Serotonin and Norepinephrine Reuptake Inhibitor
Pain Medication for Knee Osteoarthritis
This trial is for people with knee osteoarthritis pain at Northwestern University. It will last about 20 weeks and involve 180 participants. Participants will be split into three groups and given either dul
Behavioural Intervention
Dietary Interventions for Osteoarthritis Pain
This trial will investigate the efficacy of low-carb diets to reduce knee OA pain, with an emphasis on racial differences and interactions with biopsychosocial factors. #OA #RacialDisparities #PainRelief #LCD
Behavioral Intervention
Non-Surgical Management for Knee Osteoarthritis
This trial will compare two different ways of treating knee osteoarthritis. All subjects will receive a standardized approach recommended by the Department of Defense and Veterans Administration. Follow-up will occur over a 1 year period.
Platelet-Rich Plasma
Platelet-Rich Plasma vs Hyaluronic Acid for Osteoarthritis
This trial is testing whether platelet-rich plasma (PRP) is more effective than hyaluronic acid (HA) in treating knee osteoarthritis, as measured by changes in cartilage thickness and pain/function scores. Approximately 100 subjects will be treated at NorthShore University HealthSystem.
Trials for OA Patients
Corticosteroid
Methylprednisolone for Knee Arthritis
"This trial is testing if a specific steroid medication, methylprednisolone, can improve patient outcomes after knee replacement surgery. The steroid will be given in decreasing doses over time to see if it helps
Selective Serotonin and Norepinephrine Reuptake Inhibitor
Pain Medication for Knee Osteoarthritis
This trial is for people with knee osteoarthritis pain at Northwestern University. It will last about 20 weeks and involve 180 participants. Participants will be split into three groups and given either dul
Behavioural Intervention
Dietary Interventions for Osteoarthritis Pain
This trial will investigate the efficacy of low-carb diets to reduce knee OA pain, with an emphasis on racial differences and interactions with biopsychosocial factors. #OA #RacialDisparities #PainRelief #LCD
Behavioral Intervention
Non-Surgical Management for Knee Osteoarthritis
This trial will compare two different ways of treating knee osteoarthritis. All subjects will receive a standardized approach recommended by the Department of Defense and Veterans Administration. Follow-up will occur over a 1 year period.
Platelet-Rich Plasma
Platelet-Rich Plasma vs Hyaluronic Acid for Osteoarthritis
This trial is testing whether platelet-rich plasma (PRP) is more effective than hyaluronic acid (HA) in treating knee osteoarthritis, as measured by changes in cartilage thickness and pain/function scores. Approximately 100 subjects will be treated at NorthShore University HealthSystem.
Phase 3 Trials
Non-Surgical Interventions for Knee Osteoarthritis
This trial will compare commonly recommended treatments to reduce pain and functional limitations in KOA. The results will lead to improved patient selection for treatment and inform evidence based guidelines by offering well-tested, effective, non-surgical alternatives.
Stem Cell Therapy
Stem Cell Treatment for Knee Osteoarthritis
This trial is testing a new treatment that uses cells from a patient's own fat to help repair knee damage in people with knee osteoarthritis. The cells are injected into the knee to reduce pain and improve joint function. This type of therapy has been increasingly studied and used for treating knee osteoarthritis due to its potential to reduce pain and improve joint function.
Monoclonal Antibodies
RTX-GRT7039 for Osteoarthritis
This trial tests a new treatment to help people with knee osteoarthritis who still have pain despite other treatments. The treatment works by affecting the body's pain signals. The study will observe patients for up to a year to confirm its effectiveness and safety.
Cannabinoid
CBD for Knee Osteoarthritis
This trial is testing if CBD tablets that dissolve in the mouth can reduce pain and improve function in people with knee osteoarthritis. The study targets patients who are already doing physiotherapy and home exercises. CBD is thought to work by interacting with the body's system that controls pain and inflammation. CBD is a non-euphoric component of cannabis that has shown potential in relieving pain and reducing inflammation in osteoarthritis.
Hormone Therapy
MFat vs Corticosteroid Injection for Knee Osteoarthritis
This trial is testing a new treatment where a patient's own fat is processed and injected into their knee to help with pain and function in people with moderate knee osteoarthritis. The goal is to see if this method works better by reducing inflammation and promoting healing. This approach has shown promising results in reducing pain and improving function.
Trials With No Placebo
Corticosteroid
Methylprednisolone for Knee Arthritis
"This trial is testing if a specific steroid medication, methylprednisolone, can improve patient outcomes after knee replacement surgery. The steroid will be given in decreasing doses over time to see if it helps
Behavioural Intervention
Dietary Interventions for Osteoarthritis Pain
This trial will investigate the efficacy of low-carb diets to reduce knee OA pain, with an emphasis on racial differences and interactions with biopsychosocial factors. #OA #RacialDisparities #PainRelief #LCD
Behavioral Intervention
Non-Surgical Management for Knee Osteoarthritis
This trial will compare two different ways of treating knee osteoarthritis. All subjects will receive a standardized approach recommended by the Department of Defense and Veterans Administration. Follow-up will occur over a 1 year period.
Platelet-Rich Plasma
Platelet-Rich Plasma vs Hyaluronic Acid for Osteoarthritis
This trial is testing whether platelet-rich plasma (PRP) is more effective than hyaluronic acid (HA) in treating knee osteoarthritis, as measured by changes in cartilage thickness and pain/function scores. Approximately 100 subjects will be treated at NorthShore University HealthSystem.
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Frequently Asked Questions
Introduction to knee osteoarthritis
What are the top hospitals conducting knee osteoarthritis research?
When it comes to advancing research and finding innovative treatments for knee osteoarthritis, several hospitals are making significant contributions. In Seattle, the University of Washington is at the forefront with three ongoing clinical trials dedicated to this condition. While they may not have conducted any previous knee osteoarthritis trials, their active involvement demonstrates a commitment to improving patient outcomes. Similarly, in Salt Lake City, the University of Utah is also conducting three active knee osteoarthritis trials, signaling their dedication to exploring new treatment options. Moving towards BioSolutions Clinical Research Center in La Mesa and Affinity Health in Oak Brook both hosting two ongoing investigations related to this condition; each institution aims at creating breakthroughs that can make a substantial impact on patients' lives. Lastly joining them is Healthcare Research Network located in Hazelwood where multiple efforts are underway to understand and develop innovative approaches against knee osteoarthritis.
Knee osteoarthritis affects millions of people worldwide and can cause pain, stiffness, and reduced mobility. By actively engaging in these clinical trials for knee osteoarthritis across various locations throughout the United States healthcare landscape offers hope for those suffering from this degenerative joint disease.
Which are the best cities for knee osteoarthritis clinical trials?
In the realm of knee osteoarthritis clinical trials, several cities emerge as prominent hubs for research. La Mesa, California leads the way with 8 active trials investigating treatments like Lorecivivint, canakinumab, and JointStem. San Antonio, Texas also boasts 8 ongoing studies focusing on interventions such as Lorecivivint, DoD/VA CPG Core Set + PT, and Microfragmented Adipose Tissue (Mfat). Chicago, Illinois follows closely behind with 7 active trials delving into potential treatments like Lorecivivint, DFV890, and Naproxen 500 Mg. Together these cities provide individuals suffering from knee osteoarthritis access to cutting-edge clinical trials that pave the path towards advancements in treatment options and improved quality of life.
Which are the top treatments for knee osteoarthritis being explored in clinical trials?
Clinical trials are at the forefront of advancing treatment options for knee osteoarthritis. Among the top treatments being explored in these trials are:
- Platelet-rich plasma (PRP): A therapy that utilizes a concentrated dose of platelets from the patient's own blood to stimulate healing and reduce inflammation.
- Mesenchymal stem cells (MSCs): Stem cell-based therapies that have shown promise in promoting tissue regeneration and reducing pain.
- Hyaluronic acid injections: Injections of hyaluronic acid into the affected joint, providing lubrication and cushioning to alleviate symptoms. These treatments offer hope for patients with knee osteoarthritis, potentially improving their quality of life by addressing pain and mobility issues.
What are the most recent clinical trials for knee osteoarthritis?
Recent clinical trials offer hope for individuals suffering from knee osteoarthritis. Group A TA 40 mg, a Phase 4 trial, has shown promise in providing relief for those with this degenerative joint disease. Additionally, GNSC-001 (low dose), Kenalog with 0ml bupivacaine, RHH646, and Microfragmented Adipose Tissue (Mfat) have also demonstrated potential benefits as treatment options for knee osteoarthritis during their respective phases of research. These studies mark significant strides in the quest to improve the quality of life for patients grappling with this debilitating condition.
What knee osteoarthritis clinical trials were recently completed?
Several recent clinical trials have focused on advancing our understanding and treatment of knee osteoarthritis. Notably, a trial sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) investigating the efficacy of Lasmiditan in managing this condition was recently completed. Additionally, another significant study led by the Hospital for Special Surgery examined the potential benefits of Platelet-Rich Plasma (PRP) injections for knee osteoarthritis patients. These advancements provide valuable insights into new therapeutic approaches that may help alleviate symptoms and improve quality of life for individuals living with knee osteoarthritis.