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Thoracic epidural analgesia for Post Thoracotomy Pain Syndrome

N/A
Waitlist Available
Led By Ehab H Gendy, MD
Research Sponsored by National Cancer Institute, Egypt
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Summary

The thoracic epidural block (TEB) and thoracic paravertebral block (TPVB) are the most commonly used techniques for analgesia after thoracic surgery.Recently, erector spinae plane block (ESPB) was reported as a treatment for thoracic neuropathic pain.Dexmedetomidine has been primarily used for intra- venous sedation in intensive care settings. The unique analgesic properties of dexmedetomidine have encouraged the anesthesiologists to use it perineurally. This study aims to evaluate the effect ultrasound erector spinae plane block with dexmedetomidine infusion in management of acute and chronic post thoracotomy pain.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Pain intensity score
Secondary study objectives
Number of patients who will develop post-thoracotomy pain syndrome.

Trial Design

3Treatment groups
Active Control
Group I: Thoracic epidural analgesiaActive Control1 Intervention
Patients will preoperatively receive thoracic epidural at the level T5 \& T6 with bolus 20 ml of levobupivacaine 0.25% then levobupivacaine 0.1% infused at a rate of 0.1 mL/Kg/h until chest tube removal ( 5-6 days).
Group II: ESPB with levobupivacaineActive Control1 Intervention
patients will preoperatively receive US guided ESP block on the side to be operates upon, the puncture point of the skin is infiltrated with 2% lidocaine, and once the structures are identified with ultrasound at the level of T5 transverse process, we will inject bolus 20ml of levobupivacaine 0.25% on the deep aspect of erector spinae muscle then catheter inserted.A 20 ml bolus of levobupivacaine 0.1% is injected every 6 hours until chest tube removal.
Group III: ESPB with levobupivacaine and dexmedetomidineActive Control1 Intervention
patients will preoperatively receive US guided ESP block on the side to be operates upon, the puncture point of the skin is infiltrated with 2% lidocaine, and once the structures are identified with ultrasound at the level of T5 transverse process, we will inject bolus 20ml of levobupivacaine 0.25% plus 0.5mic/Kg dexmedetomidine on the deep aspect of erector spinae muscle then catheter inserted. 20 ml bolus of levobupivacaine 0.1% with dexmedetomidine 0.5 μg/Kg was injected every 6 hours until chest tube removal.

Find a Location

Who is running the clinical trial?

National Cancer Institute, EgyptLead Sponsor
108 Previous Clinical Trials
8,297 Total Patients Enrolled
2 Trials studying Post Thoracotomy Pain Syndrome
291 Patients Enrolled for Post Thoracotomy Pain Syndrome
Ehab H Gendy, MDPrincipal InvestigatorAssistant Professor of Anesthesia, intensive care and pain releif
2 Previous Clinical Trials
160 Total Patients Enrolled
~20 spots leftby Sep 2025
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