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Electrolyte Supplement

50 mg/kg for Asthma (IMPACT-ED Trial)

Phase 2
Waitlist Available
Research Sponsored by University of Utah
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 months of enrollment.
Awards & highlights

IMPACT-ED Trial Summary

This trial will test whether magnesium sulfate can be used in the emergency department to prevent hospitalization for children with severe asthma.

IMPACT-ED Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 months of enrollment.
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 months of enrollment. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Enrollment
Secondary outcome measures
Adverse events and safety profiles
Hospital course
Hospitalization
+2 more

IMPACT-ED Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: 50 mg/kgActive Control1 Intervention
Doses for each IVMg arm will be prepared in identical manner, by drawing a specified volume of IVMg from the commercial container using sterile technique and mixing in a polyvinylchloride container with a specified volume of sterile water. For the 50 mg/kg arm, this will be accomplished by mixing 25 mL of IVMg (80 mg/mL) with 15 mL of sterile water for a final concentration of 50 mg/mL and volume of 40 mL. After randomization the institutional pharmacist will draw equivolumetric dosages (1 mL/kg, with max of 40 mL) from previously prepared vials. The dose will be delivered by the clinical nurse over 20 minutes through a peripheral IV.
Group II: 75 mg/kgActive Control1 Intervention
Doses for each IVMg arm will be prepared in identical manner, by drawing a specified volume of IVMg from the commercial container using sterile technique and mixing in a polyvinylchloride container with a specified volume of sterile water. For the 75 mg/kg arm, this will be accomplished by mixing 37.5 mL of IVMg (80 mg/mL) with 2.5 mL of sterile water for a final concentration of 75 mg/mL and volume of 40 mL. After randomization the institutional pharmacist will draw equivolumetric dosages (1 mL/kg, with max of 40 mL) from previously prepared vials. The dose will be delivered by the clinical nurse over 20 minutes through a peripheral IV.
Group III: PlaceboPlacebo Group1 Intervention
For the placebo arm, 40 mL of 0.9% sodium chloride solution will be drawn into a polyvinylchloride container identical in appearance to the containers used for the IVMg arms. After randomization the institutional pharmacist will draw equivolumetric dosages (1 mL/kg, with max of 40 mL) from previously prepared vials. The dose will be delivered by the clinical nurse over 20 minutes through a peripheral IV.

Find a Location

Who is running the clinical trial?

University of UtahLead Sponsor
1,104 Previous Clinical Trials
1,782,483 Total Patients Enrolled
5 Trials studying Asthma
176,455 Patients Enrolled for Asthma
Children's Hospital of PhiladelphiaOTHER
710 Previous Clinical Trials
8,588,912 Total Patients Enrolled
13 Trials studying Asthma
4,689 Patients Enrolled for Asthma
Nationwide Children's HospitalOTHER
341 Previous Clinical Trials
5,220,447 Total Patients Enrolled
3 Trials studying Asthma
76 Patients Enrolled for Asthma
~19 spots leftby Jun 2025
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