89Zr-DFO-huJ591 PET Scan for Prostate Cancer

Recruiting in Palo Alto (17 mi)

Overseen byMichael Morris, MD

Age: 18+

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Waitlist Available

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial is testing a new type of scan to see if it can better detect prostate cancer that has spread, especially to the bones. The scan uses a special substance to highlight cancer cells in the body. Researchers hope this will improve future cancer treatments.

Eligibility Criteria

This trial is for adult males over 18 with confirmed prostate cancer at MSKCC, showing disease progression either through scans or rising PSA levels. Participants must have a performance status of 60+ on the Karnofsky scale and be able to consent. Men who've had anaphylactic reactions to J591 or FDG, or those with certain abnormal liver test results are excluded.

Inclusion Criteria

I am a man and I am 18 years old or older.

I am mostly able to care for myself and carry out daily activities.

I am a man and I am 18 years old or older.

+6 more

Exclusion Criteria

My liver function tests are within normal limits, except I may have Gilbert's disease.

Previous anaphylactic reaction to either J591 or FDG

Participant Groups

The study tests the safety and accuracy of a new PET scan using an experimental tracer called 89Zr-DFO-huJ591, aimed at detecting metastatic prostate cancer. It compares this new scan's effectiveness against standard imaging techniques like CT, MRI, bone scans, and FDG PET scans.

1Treatment groups

Experimental Treatment

Group I: 89Zr-DFO-huJ591Experimental Treatment1 Intervention

Registered patients will undergo a baseline FDG PET scan up to 14 days before administration of a single dose of the 89Zr-DFO-huJ591 tracer, this scan is considered for research purposes. The exception to the 14-day timeframe is that patients who have already had an FDG PET scan up to 4 weeks prior to registration are not required to repeat the FDG PET scan on study.