Wild Rice for Cardiovascular Health
Recruiting in Palo Alto (17 mi)
Overseen byMohammed H Moghadasian, PhD
Age: 18 - 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Manitoba
Must not be taking: Cardiovascular, Diabetes, Cancer
Disqualifiers: Pregnant, Lactating, Smokers, Obese
No Placebo Group
Trial Summary
What is the purpose of this trial?In this study 24 adult males and adult females, with overall healthy condition, will consume approximately 30 grams of wild rice every day for 28 days. Cardiovascular risk factors will be assessed at the beginning and at the end of the study.
Will I have to stop taking my current medications?
The trial requires that participants are not currently on any medications for cardiovascular, diabetes, and cancer diseases.
What data supports the effectiveness of the treatment Wild Rice for cardiovascular health?
Research shows that wild rice can help prevent atherosclerosis (a condition where arteries become clogged with fatty substances) in mice by reducing inflammation and cholesterol levels. It also has antioxidant properties and is rich in nutrients, which may contribute to its heart health benefits.
12345Is wild rice safe for human consumption?
Wild rice is generally considered safe for human consumption and is recognized as a health-promoting food by the US Food and Drug Administration. It is rich in nutrients and has been shown to have antioxidant and lipid-lowering properties in experimental settings.
12345How does the treatment wild rice differ from other treatments for cardiovascular health?
Wild rice is unique because it is a whole grain rich in antioxidants and phytochemicals, which help reduce inflammation and cholesterol levels, potentially preventing atherosclerosis (hardening of the arteries). Unlike many standard treatments, wild rice is a natural dietary option that can be easily incorporated into meals.
12346Eligibility Criteria
This trial is for healthy men and women aged between 20 to 40 years old. Participants will be required to consume wild rice daily, so they should not have any known allergies or dietary restrictions that prevent them from eating this food.Inclusion Criteria
I am healthy.
I am female.
I am male.
+1 more
Exclusion Criteria
Non-smokers
Non-pregnant
Non-lactating
+2 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants consume approximately 30 grams of wild rice every day for 28 days
4 weeks
2 visits (in-person)
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Participant Groups
The study investigates the cardiovascular benefits of consuming approximately 30 grams of wild rice every day for a period of 28 days. Researchers will measure participants' heart health factors before and after the trial.
1Treatment groups
Experimental Treatment
Group I: Wild riceExperimental Treatment1 Intervention
Participants will consume one serving of the test food containing wild rice every day over 28 days.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
St. Boniface Hospital Research Center Asper clinicalWinnipeg, Canada
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Who Is Running the Clinical Trial?
University of ManitobaLead Sponsor
References
Wild rice (Zizania palustris L.) prevents atherogenesis in LDL receptor knockout mice. [2013]Dietary modifications including healthy eating constitute one of the first line strategies for prevention and treatment of cardiovascular disease (CVD) risk factors including high cholesterol and atherosclerosis. The purpose of the present study was to investigate the potential cardiovascular benefits of wild rice in male and female LDL-receptor-deficient (LDLr-KO) mice.
Nutritional constituents and health benefits of wild rice (Zizania spp.). [2018]Wild rice (Zizania spp.) seems to have originated in North America and then dispersed into Eastern Asia and other parts of the world. Nutritional analysis shows that wild rice is rich in minerals, vitamins, protein, starch, dietary fiber, and various antioxidant phytochemicals, while it is low in fat. Wild rice has been recognized as a whole grain by the US Food and Drug Administration; in the North American marketplace it is currently sold as and considered to be a health-promoting food. Recent scientific studies have revealed antioxidant and lipid-lowering properties of wild rice, while others have documented cardiovascular benefits associated with the long-term consumption of wild rice in experimental settings. The present review article summarizes various features of wild rice and its cultivation, including its plantation, harvest, nutritional composition, and biological properties. While evidence for the cardiovascular benefits of wild rice consumption is accumulating, additional studies are warranted to determine the clinical benefits of regular consumption of wild rice.
Inhibitory Effects of North American Wild Rice on Monocyte Adhesion and Inflammatory Modulators in Low-Density Lipoprotein Receptor-Knockout Mice. [2017]The present study examined the effects of wild rice on monocyte adhesion, inflammatory and fibrinolytic mediators in low-density lipoprotein receptor-knockout (LDLr-KO) mice. Male LDLr-KO mice received a cholesterol (0.06%, w/w)-supplemented diet with or without white or wild rice (60%, w/w) for 20 weeks. White rice significantly increased monocyte adhesion and abundances of monocyte chemoattractant protein-1, tissue necrosis factor-α, intracellular cell adhesion molecule-1, plasminogen activator inhibitor-1, urokinase plasminogen activator (uPA), and uPA receptor in aortae and hearts of LDLr-KO mice compared to the control diet. Wild rice inhibited monocyte adhesion to the aorta, atherosclerosis, and abundances of the inflammatory and fibrinolytic regulators in the cardiovascular tissue of LDLr-KO mice compared to white rice. White or wild rice did not significantly alter the levels of cholesterol, triglycerides, or antioxidant enzymes in plasma. The anti-atherosclerotic effect of wild rice may result from its inhibition on monocyte adhesion and inflammatory modulators in LDLr-KO mice.
Combination effects of wild rice and phytosterols on prevention of atherosclerosis in LDL receptor knockout mice. [2017]Dietary modifications including healthy eating constitute one of the first line strategies for prevention and treatment of atherosclerotic cardiovascular diseases (CVD), including atherosclerosis. In this study, we assessed anti-atherogenic effects of a combination of wild rice and phytosterols in low-density lipoprotein receptor knockout (LDL-r-KO) mice. Male LDL-r-KO mice were divided into four groups and fed with: (1) control diet; (2) the control diet containing 60% (w/w) wild rice; (3) the control diet containing 2% (w/w) phytosterols; or (4) the control diet containing both wild rice and phytosterols for 20weeks. All diets were supplemented with 0.06% (w/w) dietary cholesterol. Blood samples, hearts, and feces were collected and used for biochemical and histological examination. Consumption of 60% (w/w) wild rice in combination with 2% (w/w) phytosterols significantly reduced the size and severity of atherosclerotic lesions in the aortic roots as compared to those in the control group. This effect was associated with significant reductions in plasma total, LDL and VLDL cholesterol concentrations as well as an increase in fecal cholesterol excretion. In conclusion, the dietary combination of wild rice and phytosterols prevents atherogenesis in this animal model. Further investigations are needed to understand mechanisms of action and potential clinical outcome of such dietary intervention.
Anti-Atherosclerotic Properties of Wild Rice in Low-Density Lipoprotein Receptor Knockout Mice: The Gut Microbiome, Cytokines, and Metabolomics Study. [2020]We previously reported the anti-atherogenic properties of wild rice in low-density lipoprotein receptor knockout (LDL-r-KO) mice. The present study aimed to discover the mechanism of action for such effects.
Antioxidant activity of commercial wild rice and identification of flavonoid compounds in active fractions. [2015]The health benefits of whole grain consumption have been attributed to their content of complex carbohydrates, vitamins, minerals, and other phytochemical constituents. Wild rice is a whole grain finding applications in gourmet foods due to its nutritional value and unique taste. However, little is known about its antioxidant properties and phytochemical components. The objectives of this study were to evaluate the antioxidant properties of wild rice. Eleven commercial wild rice samples (raw, mixed, and processed) were extracted with acetone and fractionated using a Sephadex LH-20 column. 2,2-Diphenyl-1-picrylhydrazyl radical (DPPH(*)) scavenging activity, oxygen radical absorbance capacity (ORAC), and total phenolic content were evaluated to determine the antioxidant properties of wild rice. The antioxidant activity of wild rice was found to be 30 times greater than that of the control white rice. Significant differences (p