← Back to Search

Multidisciplinary Team Care for Breast Cancer (TITAN Trial)

Phase 2

Waitlist Available

Research Sponsored by University of Alberta

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

histologically confirmed malignancy (breast or lymphoma);

scheduled to receive anthracycline and/or trastuzumab-based chemotherapy;

Must not have

previous radiotherapy to thorax.

previous anthracycline or trastuzumab-based therapy;

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from baseline to 12 months

Awards & highlights

No Placebo-Only Group

Summary

This trial will assess whether receiving extra assessments and early interventions from teams of health care professionals is helpful for people diagnosed with cancer.

Who is the study for?

This trial is for adults over 18 with breast cancer or lymphoma, scheduled for specific chemotherapy treatments, and able to attend follow-ups. It's not for those with heart issues, prior thorax radiotherapy, previous similar chemo treatments, physical disability impeding certain tests, psychiatric conditions affecting consent, or involvement in related studies.

What is being tested?

The TITAN Study is testing whether extra care from a team of various health professionals (like nurses and dietitians) can benefit people with cancer during and after treatment. Participants will be randomly assigned to receive either this multidisciplinary intervention or the usual care.

What are the potential side effects?

Since this study focuses on additional assessments rather than medication side effects are not the main concern; however, any interventions introduced by the multidisciplinary team may carry their own risks depending on individual patient circumstances.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My cancer (breast or lymphoma) has been confirmed through tissue examination.

Select...

I am scheduled for chemotherapy that includes anthracycline or trastuzumab.

Select...

I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have had radiation therapy to my chest area before.

Select...

I have had treatments with anthracycline or trastuzumab.

Select...

I do not have heart failure, cardiomyopathy, or an LVEF below 50%.

Select...

I have a physical disability that prevents me from undergoing exercise tests or DEXA scans.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from baseline to 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from baseline to 12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

cardiac MRI

Secondary study objectives

serum biomarkers

Other study objectives

multidisciplinary team interventions

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: multidisciplinary team interventionExperimental Treatment1 Intervention

Intervention arm receives regular assessments and treatments from cardiology team, clinical nutrition, pharmacist, exercise physiologist and physiotherapist

Group II: Observational armActive Control1 Intervention

Participants randomized to observational arm will receive usual care.

0 / 7Eligibility criteria met