What side effects are associated with this type of intervention?

Common treatments for fatigue include creatine loading, caffeine ingestion, and pharmacologic agents like modafinil, aspirin, and carnitine. Creatine loading may delay neuromuscular fatigue but can cause gastrointestinal discomfort and weight gain. Caffeine can enhance alertness and delay fatigue but may lead to insomnia, jitteriness, and increased heart rate. Modafinil is used to treat fatigue in conditions like multiple sclerosis but can cause headaches, nausea, and anxiety. Aspirin may help with fatigue but can lead to gastrointestinal issues and increased bleeding risk. Carnitine is generally well-tolerated but can cause mild gastrointestinal symptoms. Cognitive tasks performed during fatiguing contractions can exacerbate muscle fatigue and cognitive load, potentially leading to decreased performance and increased perceived exertion.

What prior FDA approvals exist?

There are no specific FDA-approved treatments for fatigue directly related to cognitive load and muscle fatigue mentioned in the provided context. However, treatments for conditions like fibromyalgia, which include symptoms of fatigue, might be relevant. Drugs such as pregabalin and duloxetine have been studied for fibromyalgia and have shown some efficacy in managing fatigue. Additionally, cognitive-behavioral interventions have been explored as a treatment option for managing fatigue in fibromyalgia patients.

What other types of research exist?

Promising novel alternatives to cognitive tasks for treating fatigue in 2024 include: 1) Aerobic exercise programs, which have shown feasibility and effectiveness in reducing fatigue. 2) Cognitive-behavioral therapy (CBT), which has been effective in managing fatigue, especially in conditions like fibromyalgia. 3) Pharmacological treatments such as pregabalin and duloxetine, which have demonstrated efficacy in reducing fatigue symptoms. 4) Integrative therapies like progressive muscle relaxation and guided imagery, which have been effective in reducing fatigue and improving quality of life.

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Cognitive Task Performance During Fatigue

N/A

Recruiting

Led By Hugo Pereira, PhD

Research Sponsored by University of Oklahoma

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Healthy individuals aged between 18-35 and 65-90

Be older than 18 years old

Must not have

History of neuromuscular disease

Timeline

Screening 3 weeks

Treatment Varies

Follow Up each session will take approximately 2-3 hours (total of 4 test sessions

Awards & highlights

No Placebo-Only Group

Summary

This trial will study how doing a mental task affects muscle fatigue during exercise. It involves general individuals and aims to see if mental effort changes how tired muscles get.

Who is the study for?

This trial is for healthy individuals in two age groups: young adults aged 18-35 and older adults aged 65-90. It's not suitable for those with neuromuscular diseases or anyone who has metal implants or joint replacements.

What is being tested?

The study is examining how performing a cognitive task can affect fatigue during muscle contractions, which might help understand the impact of aging on mental and physical performance.

What are the potential side effects?

Since this trial involves a cognitive task, there may be minimal to no side effects. Participants could potentially experience mental fatigue or stress from the tasks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am healthy and aged 18-35 or 65-90.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have a history of muscle or nerve diseases.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ each session will take approximately 2-3 hours (total of 4 test sessions

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~each session will take approximately 2-3 hours (total of 4 test sessions

This trial's timeline: 3 weeks for screening, Varies for treatment, and each session will take approximately 2-3 hours (total of 4 test sessions for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

anxiety levels

arterial pressure

fatigue

+1 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups

Experimental Treatment

Group I: young womenExperimental Treatment1 Intervention

Individuals will participate in 1 familiarization and 3 test sessions

Group II: young menExperimental Treatment1 Intervention

Individuals will participate in 1 familiarization and 3 test sessions

Group III: older womenExperimental Treatment1 Intervention

Individuals will participate in 1 familiarization and 3 test sessions

Group IV: older menExperimental Treatment1 Intervention

Individuals will participate in 1 familiarization and 3 test sessions

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

cognitive task

2019

N/A

~300

0 / 2Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for fatigue, such as exercise therapy, cognitive behavioral therapy (CBT), and mindfulness-based stress reduction (MBSR), work through different mechanisms to alleviate symptoms. Exercise therapy enhances muscle strength and endurance, reducing physical fatigue. CBT helps patients reframe negative thoughts and develop coping strategies, which can alleviate mental fatigue. MBSR reduces stress and improves emotional regulation, decreasing both mental and physical fatigue. These treatments are crucial for fatigue patients as they address both physical and psychological aspects, providing a holistic approach to managing fatigue.

The lasting effects of resistance and endurance exercise interventions on breast cancer patient mental wellbeing and physical fitness.Low-level phototherapy to improve exercise capacity and muscle performance: a systematic review and meta-analysis.Exercise therapy for chronic fatigue syndrome.