Whole Brain vs Stereotactic Radiation for Brain Cancer

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen by Ayal Aizer, MD, MPH

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Dana-Farber Cancer Institute

No Placebo Group

Trial Summary

What is the purpose of this trial?

This research study is studying two different types of radiation as treatment for brain metastases (tumors in the brain that spread from a cancer that originated elsewhere in the body)

Eligibility Criteria

This trial is for adults aged 18-80 with solid tumors that have spread to the brain, showing 5-20 metastases on MRI. They must be in good physical condition (Karnofsky score ≥70) and can have had previous systemic therapy. Excluded are those who've had brain radiation before, cannot get an MRI or gadolinium contrast, have severe kidney disease, certain cancers like small cell lung cancer, lymphoma or myeloma, or a very large tumor over 5 cm.

Inclusion Criteria

I am able to care for myself but cannot do normal activities without help.

I have a confirmed solid tumor with untreated brain metastases.

I have had treatment that affects my whole body.

Exclusion Criteria

I have had radiation treatment for cancer that spread to my brain.

I have small cell lung cancer, lymphoma, or myeloma.

I had surgery to remove one or more brain tumors but haven't started follow-up radiation therapy.

Participant Groups

The study compares two radiation treatments for patients with multiple brain tumors from another cancer source: whole-brain radiation versus stereotactic radiation (SRS), which targets specific areas. It's designed to see which method is more effective at treating these types of brain metastases.

Group I: Stereotactic Radiation (SRS) Experimental Treatment 1 Intervention

* MRI will be performed prior to radiation is administered * Radiation will be given in 1-5 fractions (dose depends on the size of the tumor that will be treated)

Group II: Whole Brain Radiation Active Control 1 Intervention

* MRI will be performed prior to radiation is administered * A hippocampal sparing approach will be used when possible * Dose will be 30 Gy in 10 fractions

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Brigham and Women's Hospital Boston, MA

Dana Farber Cancer Institute Boston, MA

Who Is Running the Clinical Trial?

Dana-Farber Cancer Institute Lead Sponsor

Brigham and Women's Hospital Collaborator

References