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Cisplatin + Ifosfamide + Paclitaxel for Penile Cancer

Phase 2
Waitlist Available
Led By Lance Pagliaro, MD
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up restaging with second and fourth 21-day cycles followed by surgery
Awards & highlights
Approved for 10 Other Conditions
All Individual Drugs Already Approved
No Placebo-Only Group

Summary

Primary Objective: -To evaluate the feasibility and efficacy of multimodality treatment (neoadjuvant chemotherapy prior to extirpative surgery) for clinical stage TXN2-3M0 squamous cell carcinoma of the penis.

Eligible Conditions
  • Penile Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~restaging with second and fourth 21-day cycles followed by surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and restaging with second and fourth 21-day cycles followed by surgery for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of Participants With Pathologic Complete Remission (pCR)

Awards & Highlights

Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Cisplatin + Ifosfamide + PaclitaxelExperimental Treatment3 Interventions
Cisplatin 25 mg/m\^2 IV Days 1-3; Ifosfamide 1200 mg/m\^2 IV Days 1-3; Paclitaxel 175 mg/m\^2 IV Day 1
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ifosfamide
FDA approved
Paclitaxel
FDA approved
Cisplatin
FDA approved

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
3,058 Previous Clinical Trials
1,800,691 Total Patients Enrolled
1 Trials studying Penile Cancer
20 Patients Enrolled for Penile Cancer
Lance Pagliaro, MDPrincipal InvestigatorM.D. Anderson Cancer Center
2 Previous Clinical Trials
17 Total Patients Enrolled
~1 spots leftby Oct 2025
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