A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease
Recruiting in Palo Alto (17 mi)
+39 other locations
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 2
Waitlist Available
Sponsor: Surface Ophthalmics, Inc.
Prior Safety Data
Trial Summary
What is the purpose of this trial?This trial is testing SURF-100 eye drops to see if they can help adults with dry eyes by keeping their eyes moist and reducing discomfort.
Eligibility Criteria
Inclusion Criteria
Adults at least 18 years of age at the time of the Screening visit.
Willing and able to comply with all study procedures and attend all study visits.
Willing to suspend use of tear substitutes at least 72 hours prior to Visit 2 (Day 0) through Visit 7 (Day 98).
+7 more
Participant Groups
7Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: SURF-100 (a combination of 0.3% Mycophenolic Acid and 0.01% Betamethasone Sodium Phosphate)Experimental Treatment1 Intervention
One drop in the study eye (and fellow eye, if applicable) twice daily for 84 days
Group II: Mycophenolic Acid 0.3%Experimental Treatment1 Intervention
One drop in the study eye (and fellow eye, if applicable) twice daily for 84 days.
Group III: Mycophenolic Acid 0.1%Experimental Treatment1 Intervention
One drop in the study eye (and fellow eye, if applicable) twice daily for 84 days.
Group IV: Betamethasone Sodium Phosphate 0.01%Experimental Treatment1 Intervention
One drop in the study eye (and fellow eye, if applicable) twice daily for 84 days.
Group V: Cyclosporine 0.05% Ophthalmic EmulsionActive Control1 Intervention
One drop in the study eye (and fellow eye, if applicable) twice daily for 84 days
Group VI: Lifitegrast 5% Ophthalmic SolutionActive Control1 Intervention
One drop in the study eye (and fellow eye, if applicable) twice daily for 84 days
Group VII: VehiclePlacebo Group1 Intervention
One drop in the study eye (and fellow eye, if applicable) twice daily for 84 days.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Black Hills Regional Eye InstituteRapid City, SD
Kentucky Eye InstituteLexington, KY
Total Eye Care, PAMemphis, TN
EyeSight Ophthalmic ServicesSomersworth, NH
More Trial Locations
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Who Is Running the Clinical Trial?
Surface Ophthalmics, Inc.Lead Sponsor
Surface Pharmaceuticals, Inc.Lead Sponsor