Comparison of Three Different Initial Treatments Without Protease Inhibitors for HIV Infection
Trial Summary
What is the purpose of this trial?
The purpose of this study is to compare the effectiveness, safety, and tolerability of 3 anti-HIV combination treatments that do not use protease inhibitors (PIs). The current rule for starting treatment of HIV infection is to combine members from different classes of anti-HIV drugs, such as 2 nucleoside reverse transcriptase inhibitors (NRTIs) and either a PI or a nonnucleoside reverse transcriptase inhibitor (NNRTI). However, these combinations can be complicated and difficult to take, can cause a number of side effects, and may become ineffective. Combinations that are simpler, better tolerated, and more effective are needed. Because PIs can cause long-term side effects and because HIV can become resistant to many of them at the same time, anti-HIV combination treatments that do not use PIs are being tested.
Eligibility Criteria
Inclusion Criteria
Treatment Details
Interventions
- NNRTIs (Non-Nucleoside Reverse Transcriptase Inhibitor)
- NRTIs (Nucleoside Reverse Transcriptase Inhibitor)