Melatonin for Postoperative Pain
Trial Summary
What is the purpose of this trial?
The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption. Patients will receive either melatonin or a placebo for three nights prior to surgery and we will measure pre-operative anxiety, preoperative sleep quality, post op pain medication consumption, post op pain scores, and blood values.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently taking melatonin or have a history of using psychotropic drugs (medications affecting the mind).
What data supports the effectiveness of the drug melatonin for reducing postoperative pain?
Research shows that melatonin can reduce postoperative pain severity, as seen in studies where patients undergoing surgeries like lumbar disc and colorectal surgeries experienced less pain when given melatonin compared to a placebo. Melatonin's analgesic (pain-relieving) effects are supported by its ability to reduce pain and anxiety, making it a potentially effective option for managing postoperative pain.12345
Is melatonin safe for human use?
Melatonin is generally considered safe for human use, with studies showing it is well-tolerated in both children and adults for sleep-related issues. However, there is limited long-term safety data, and its effects during pregnancy or interactions with other medications are not fully understood.678910
How does the drug melatonin differ from other treatments for postoperative pain?
Melatonin is unique for postoperative pain management because it is administered sublingually (under the tongue) before surgery, which can help reduce pain severity and anxiety after surgery. Unlike traditional pain medications, melatonin also has sedative and anti-inflammatory properties, making it a novel option for improving patient comfort and cooperation post-surgery.14111213
Eligibility Criteria
This trial is for healthy adults aged 18-35 needing wisdom tooth surgery under IV sedation, without allergies to melatonin or pain meds, no chronic pain or psychiatric conditions, not pregnant, and not currently using melatonin. They must be able to understand and sign the consent form.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Preoperative Treatment
Participants receive either melatonin or placebo for three nights before surgery
Surgery and Immediate Postoperative Monitoring
Participants undergo wisdom tooth surgery and immediate postoperative monitoring
Postoperative Follow-up
Participants complete surveys on pain and medication consumption for 5 days post-surgery
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Lactose pill (Other)
- Melatonin (Hormone Therapy)