Influenza Vaccine for Flu
Trial Summary
What is the purpose of this trial?
Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, if you are on immunosuppressive drugs, steroids, or have received certain treatments recently, you may not be eligible to participate.
What data supports the effectiveness of the influenza vaccine treatment?
Research shows that quadrivalent influenza vaccines, like VaxigripTetra and Fluarix Quadrivalent, provide broader protection against the flu by including two A and two B virus strains. These vaccines have been shown to be safe and effective in preventing influenza, offering better protection than older trivalent vaccines by covering more virus strains.12345
Is the influenza vaccine generally safe for humans?
The influenza vaccines, including various formulations like Fluzone Quadrivalent and Vaxigrip, have been widely used and studied for safety. They are generally considered safe, with common mild side effects such as injection-site reactions and headaches. Serious adverse reactions are rare, and extensive safety monitoring has shown no unexpected safety concerns.14678
How is the influenza vaccine treatment different from other flu treatments?
The quadrivalent influenza vaccines (QIVs) are unique because they include two influenza A subtypes and two B type viruses, offering broader protection compared to trivalent vaccines (TIVs) that only cover one B strain. This reduces the risk of the vaccine not matching the dominant circulating B strain, providing more effective protection against the flu.13459
Research Team
Eligibility Criteria
Healthy adults aged 18 and older who are willing to follow the study procedures can join. They must not have had a flu shot in the last 2 months, any blood products or immunosuppressive treatments in the past 3 months, or cancer treatments within the last 3 years. People with certain allergies, immune conditions, or those on long-term steroids cannot participate.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Vaccination
Participants receive a seasonal, inactivated, quadrivalent influenza vaccine administered intramuscularly
Follow-up
Participants are monitored for immune responses, including cellular and humoral responses, over several years
Treatment Details
Interventions
- Seasonal influenza vaccine (Virus Therapy)
Seasonal influenza vaccine is already approved in United States, European Union, Canada, Japan, Switzerland for the following indications:
- Prevention of influenza A and B virus infection
- Prevention of influenza A and B virus infection
- Prevention of influenza A and B virus infection
- Prevention of influenza A and B virus infection
- Prevention of influenza A and B virus infection
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pennsylvania
Lead Sponsor
Stanford University
Collaborator
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborator
The Scripps Research Institute
Collaborator