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Oxymetazoline for Nasal Polyps

Phase 4
Waitlist Available
Led By William C Yao, MD
Research Sponsored by The University of Texas Health Science Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
The inclusion criteria will be patients undergoing bilateral endoscopic sinus surgery (ESS) in which the same sinuses and procedures on both sides are the same for CRS with or without nasal polyposis.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during surgery approximately 2-3 hours
Awards & highlights

Study Summary

The purpose of this study is to compare the effects of Oxymetazoline and Epinephrine (which are 2 different nasal decongestants both of which are routinely used before sinus surgery) on blood loss and the surgeon's view of the surgical field during sinus surgery.

Eligible Conditions
  • Nasal Polyps
  • Sinus Endoscopy

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during surgery approximately 2-3 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and during surgery approximately 2-3 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Surgical Field Visualization During Sinus Surgery as Indicated by Score on Boezaart Grading Scale
Secondary outcome measures
Amount of Blood Loss in mL

Trial Design

2Treatment groups
Active Control
Group I: OxymetazolineActive Control1 Intervention
Pledgets will be soaked in 0.05% oxymetazoline solution Two pledgets with the associated medication will be placed into the nasal cavity; one along the floor of the nose and another directed towards the middle meatus.
Group II: EpinephrineActive Control1 Intervention
Pledgets will be soaked in 1:1000 epinephrine solution Two pledgets with the associated medication will be placed into the nasal cavity; one along the floor of the nose and another directed towards the middle meatus.

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center, HoustonLead Sponsor
919 Previous Clinical Trials
325,021 Total Patients Enrolled
1 Trials studying Nasal Polyps
58 Patients Enrolled for Nasal Polyps
William C Yao, MDPrincipal InvestigatorThe University of Texas Health Science Center, Houston
~3 spots leftby Jun 2025
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