Erector Spinae Plane Block for Postoperative Pain After Kidney Stone Surgery

Recruiting in Palo Alto (17 mi)

+1 other location

Brian M. Ilfeld, MD - Anesthesiology ...

Overseen byBrian Ilfeld, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: University of California, San Diego

Prior Safety Data

Trial Summary

What is the purpose of this trial?This is a randomized, triple-masked, placebo-controlled parallel-arm human subjects clinical trial investigating the addition of a continuous erector spinae plane nerve block to a single-injection erector spinae plane block to provide postoperative analgesia following percutaneous nephrolithotomy. Participants will all receive a single-injection nerve block and perineural catheter insertion. Following surgery, participants will be randomly allocated to receive either perineural local anesthetic or normal saline until the second day following surgery.

Eligibility Criteria

This trial is for adults over 18 who are having a kidney stone removal surgery called unilateral percutaneous nephrolithotomy and will receive an erector spinae plane block for pain. It's not for pregnant individuals, those with allergies to the drugs used, kidney problems, chronic opioid use or abuse, severe health issues limiting function, extreme obesity, or if they can't communicate with staff.

Inclusion Criteria

I am 18 years old or older.

I am having a kidney stone removal surgery on one side, lying face down.

My pain management plan includes a specific type of single-injection nerve block.

Exclusion Criteria

I cannot communicate with my doctors or hospital staff.

Known allergy to any study medication

I don't have infections where a catheter would be inserted.

+8 more

Participant Groups

The study tests whether adding a continuous nerve block to a single-injection one after kidney stone surgery reduces pain. Participants get either real local anesthetic bupivacaine or placebo saline through a catheter until the second day post-surgery.

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Active TreatmentExperimental Treatment1 Intervention

Administration of bupivacaine 0.25% through a perineural catheter inserted into the erector spinae plane (programmed intermittent bolus of 21 mL every 4 hours and no patient-controlled bolus)

Group II: PlaceboPlacebo Group1 Intervention

Administration of normal saline through a perineural catheter inserted into the erector spinae plane (programmed intermittent bolus of 21 mL every 4 hours and no patient-controlled bolus)