Beetroot Juice Therapy for Chronic Kidney Disease

Recruiting in Palo Alto (17 mi)

Overseen byMatthew J Rossman, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Recruiting

Sponsor: University of Colorado, Boulder

Prior Safety Data

Trial Summary

What is the purpose of this trial?This trial tests if drinking beetroot juice daily can help people with chronic kidney disease by improving their blood flow, movement, and thinking abilities. The juice works by boosting a molecule called nitric oxide in the body. Beetroot is known for its high concentration of inorganic nitrate, which can be converted into nitric oxide, potentially benefiting patients with chronic kidney disease by reducing blood pressure and improving renal function.

Eligibility Criteria

This trial is for people with chronic kidney disease stages II-IV who can perform basic motor and cognitive tests, have a stable body weight (BMI <40), normal albumin levels, and blood pressure above 100/60 mmHg. They shouldn't be hospitalized recently, on warfarin, or have severe heart/liver conditions.

Inclusion Criteria

Free from alcohol dependence or abuse, as defined by the American Psychiatry Association, Diagnostic and Statistical Manual of Mental Disorders (DSM-V)

Ability to give informed consent

Your albumin level is higher than 3.0 grams per deciliter.

+6 more

Exclusion Criteria

You eat a lot of foods with nitrate or take nitrate supplements, or you are very sensitive to nitrate or nitrite.

Unwilling to abstain from use of mouthwash or other oral hygiene practices (e.g., tongue scraping) outside of teeth brushing that disrupt the oral microbiome and would interfere with nitrate conversion to nitrite

I haven't donated blood in the last 8 weeks and won't donate for 8 weeks after the study.

+9 more

Participant Groups

The study tests if drinking nitrate-rich beetroot juice daily for three months improves blood vessel health, movement ability, and brain function in CKD patients by boosting nitric oxide levels compared to a nitrate-depleted version.

2Treatment groups

Active Control

Placebo Group

Group I: Nitrate-rich beetroot juiceActive Control1 Intervention

Daily dose of nitrate-rich beetroot juice (70 mL) for 3 months.

Group II: Nitrate-depleted beetroot juicePlacebo Group1 Intervention

Daily dose of nitrate-depleted beetroot juice (70 mL) for 3 months. The nitrate-depleted beetroot juice is identical in appearance, taste and caloric content to nitrate-rich beetroot juice, but with nitrate removed.