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Topical Analgesic

Capsaicin for CHS

Phase 4
Waitlist Available
Led By Angela Holian, PharmD
Research Sponsored by University of Virginia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days (outpatient phone call)
Awards & highlights

Study Summary

This trial will test if capsaicin cream can help people with a condition that causes them to vomit a lot.

Eligible Conditions
  • Cannabinoid Hyperemesis Syndrome
  • CHS

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days (outpatient phone call)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days (outpatient phone call) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Time to resolution of symptoms
Secondary outcome measures
Clinical improvement in pain score
Other outcome measures
Symptom improvement at thirty days

Side effects data

From 2018 Phase 4 trial • 80 Patients • NCT02288156
31%
nasopharyngitis
19%
Nasal congestion
13%
Cough
13%
Rhinorrhoea
6%
Pyrexia
6%
Cystitis
6%
Rhinitis
6%
Influenza
6%
Sneezing
6%
Laryngitis
6%
pain in extremity
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
0,01mM
0,1mM
0.001mM

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: CapsaicinExperimental Treatment1 Intervention
capsaicin 0.075% cream applied once topically
Group II: PlaceboActive Control1 Intervention
placebo cream applied once topically
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Capsaicin
FDA approved

Find a Location

Who is running the clinical trial?

University of VirginiaLead Sponsor
759 Previous Clinical Trials
1,245,536 Total Patients Enrolled
Angela Holian, PharmDPrincipal Investigator - University of Virginia
University of Virginia
~11 spots leftby Jun 2025
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