Procedure
DBS Therapy for Obsessive-Compulsive Disorder
This trial involves using Deep Brain Stimulation (DBS) to help patients with severe OCD who haven't responded to other treatments. The DBS device sends electrical signals to specific brain areas to control OCD symptoms by regulating abnormal brain activity.
Procedure
DBS for Treatment-Resistant Depression
This trialwill study if a brain stimulation technique (DBS) can help 6 people with depression that hasn't been helped by other treatments. Primary outcome measure will be their depression levels 6 months after the stimulation.
Popular Filters
Trials for Parkinson's Disease Patients
Procedure
Deep Brain Stimulation Adjustments for Parkinson's Disease
This trial looks at how different locations and frequencies of electrical stimulation to the subthalamic nucleus (a deep brain structure) affects cognition in Parkinson's patients who have had deep brain stimulation surgery.
Nerve Grafts + DBS Surgery for Parkinson's Disease
This trial tests the safety of implanting a patient's own nerve tissue into their brain during surgery for Parkinson's disease. The goal is to use natural substances from the nerve tissue to help protect and repair brain cells affected by the disease.
Behavioural Intervention
Alternating-Frequency DBS for Parkinson's Disease
This trial is testing a new type of brain stimulation that changes how often electrical signals are sent to the brain. It aims to help Parkinson's Disease patients who have trouble with balance and walking, problems that current treatments can't fix. By adjusting the stimulation pattern, researchers hope to improve these movement issues.
Trials for PD Patients
Procedure
Deep Brain Stimulation Adjustments for Parkinson's Disease
This trial looks at how different locations and frequencies of electrical stimulation to the subthalamic nucleus (a deep brain structure) affects cognition in Parkinson's patients who have had deep brain stimulation surgery.
Nerve Grafts + DBS Surgery for Parkinson's Disease
This trial tests the safety of implanting a patient's own nerve tissue into their brain during surgery for Parkinson's disease. The goal is to use natural substances from the nerve tissue to help protect and repair brain cells affected by the disease.
Behavioural Intervention
Alternating-Frequency DBS for Parkinson's Disease
This trial is testing a new type of brain stimulation that changes how often electrical signals are sent to the brain. It aims to help Parkinson's Disease patients who have trouble with balance and walking, problems that current treatments can't fix. By adjusting the stimulation pattern, researchers hope to improve these movement issues.
Trials With No Placebo
Procedure
Deep Brain Stimulation Adjustments for Parkinson's Disease
This trial looks at how different locations and frequencies of electrical stimulation to the subthalamic nucleus (a deep brain structure) affects cognition in Parkinson's patients who have had deep brain stimulation surgery.
Procedure
MRI to Study Deep Brain Stimulation Effects in Neurodegenerative Disease
This trial studies the effects of a treatment using electrical impulses on patients with various neurological and psychiatric conditions. Researchers will use advanced imaging techniques to understand how this treatment affects brain function and structure. This method has been used for over twenty years to treat movement disorders and is a promising treatment for other conditions.
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Frequently Asked Questions
Introduction to dbs
What are the top hospitals conducting dbs research?
When it comes to cutting-edge clinical trials in Deep Brain Stimulation (DBS), several hospitals across North America are leading the charge. In Cleveland, Ohio, the renowned Cleveland Clinic stands out with six active DBS trials. This groundbreaking treatment involves implanting electrodes into specific areas of the brain to alleviate symptoms of various neurological conditions such as [Parkinson's disease](https://www.withpower.com/clinical-trials/parkinson's-disease) and essential tremor. While Cleveland Clinic has yet to conduct any previous DBS trials, its commitment to innovation and patient care is evident through their current research efforts.
In Phoenix, Arizona, the Barrow Neurological Institute is making strides in DBS research as well. With three ongoing trials focused on this revolutionary therapy, Barrow Neurological Institute aims to improve the quality of life for individuals suffering from movement disorders and other neurological conditions. Like some other top hospitals in this field, they have yet to conduct any past DBS studies but are dedicated to pushing boundaries and finding new solutions for patients.
The University of Florida in Gainesville is also actively involved in advancing DBS treatments with three ongoing clinical trials. By investigating different aspects of DBS technology and its potential applications, researchers at this institution hope to unlock new possibilities for those living with neurological disorders.
North of the border in Toronto, Canada's Toronto Western Hospital is joining forces by also conducting three active DBS trials. Through these pioneering investigations into deep brain stimulation techniques, experts aim not only to enhance our understanding but also develop more effective treatment options for a range of conditions including dystonia and obsessive-compulsive disorder.
Lastly, on the west coast resides another influential player: The University of California Los Angeles (UCLA). With two active clinical trials centered around innovative uses for deep brain stimulation technology underway at UCLA Medical Center located within their sprawling campus; they seek novel ways that can utilize this technique beyond conventional applications like improving motor function or reducing tremors associated with Parkinson’s disease
These esteemed institutions serve as beacons illuminating the path towards groundbreaking advancements in DBS. Through their ongoing research efforts, these hospitals are not only improving the lives of patients but also paving the way for a future where neurological disorders can be effectively treated with precision and compassion.
Which are the best cities for dbs clinical trials?
In the realm of deep brain stimulation (DBS) clinical trials, several cities emerge as leading hubs for research. Cleveland, Ohio takes the forefront with 7 ongoing trials investigating various aspects like eiDBS suppression and DBS+Rehab. Toronto, Ontario follows closely behind with 6 active studies focusing on Continuous DBS and fMRI evaluations. Phoenix, Arizona also plays a significant role in advancing DBS knowledge through its 5 ongoing trials centered around VIM Stimulation and STN-PPN DBS Surgery. Additionally, Gainesville, Florida and Los Angeles, California each contribute to this field with 4 active trials exploring different facets of DBS technology and applications. These cities collectively provide individuals seeking participation in groundbreaking DBS clinical trials an array of opportunities for innovative treatment options.
Which are the top treatments for dbs being explored in clinical trials?
In the realm of clinical trials, there are several top treatments being explored for Deep Brain Stimulation (DBS). These innovative therapies hold great potential in addressing various conditions. Among them are:
- Daratumumab: 6 active DBS trials.
- Belantamab mafodotin: 4 active DBS trials.
- Lenalidomide: 3 active DBS trials.
These groundbreaking treatments have shown promise and are paving the way for future advancements in DBS research. The ongoing studies offer hope for improved outcomes and enhanced quality of life for patients living with neurologic disorders.
What are the most recent clinical trials for dbs?
Exciting developments are occurring in the field of deep brain stimulation (DBS), with recent clinical trials providing valuable insights and potential advancements. Among these trials is eiDBS suppression, a phase 4 study that became available on 9/15/2023, aiming to evaluate the effectiveness of suppressing symptoms through DBS therapy. Additionally, another trial called "1 for dbs" has entered phases 1 and 2 as of 9/1/2023, offering novel approaches for improving DBS treatments. Furthermore, investigations into ON Dopaminergic Medication (phase 1) and ON/OFF stimulation sequencing (phase 2) present promising avenues to optimize DBS outcomes. As research continues to unfold in this area, individuals living with movement disorders can look forward to improved therapeutic options arising from these groundbreaking clinical trials.
What dbs clinical trials were recently completed?
Recently completed clinical trials in the field of deep brain stimulation (DBS) have made significant strides in advancing treatment options. These trials have focused on investigating the efficacy and safety of different DBS techniques for various neurological conditions. While several studies were conducted, three noteworthy ones stand out: a trial exploring the use of DBS for Parkinson's disease was completed by Johns Hopkins University; another trial conducted by Massachusetts General Hospital investigated DBS as a potential therapy for obsessive-compulsive disorder; and finally, an international multi-center study sponsored by Medtronic explored the application of DBS for epilepsy management. These recent advancements highlight the ongoing efforts to enhance patient outcomes through innovative research in deep brain stimulation.