Ixekizumab for Refractory Uveitis

Recruiting in Palo Alto (17 mi)

Overseen byC. Stephen Foster, MD, FACS, FACR

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Recruiting

Sponsor: Massachusetts Eye Research and Surgery Institution

No Placebo Group

Prior Safety Data

Approved in 2 Jurisdictions

Trial Summary

What is the purpose of this trial?The objective of this study is to explore the efficacy of ixekizumab in treating patients with a diagnosis of non-infectious intermediate, posterior, panuveitis, or chronic steroid-dependent anterior uveitis who had failed treatment with a classic synthetic DMARD including methotrexate, mycophenolate, cyclosporin, azathioprine, cyclophosphamide and/or at least one anti-TNF agent including adalimumab, infliximab, etanercept, golimumab or certolizumab.

Eligibility Criteria

Adults with non-infectious uveitis (intermediate, posterior, panuveitis, or chronic steroid-dependent anterior uveitis) who didn't respond to certain DMARDs or anti-TNF drugs. Participants must have active eye inflammation and not be planning cataract surgery soon. They can't join if they've had recent corticosteroid implants/injections, certain eye conditions/surgeries, severe infections, other clinical trial participation recently, major surgeries planned/just done, live vaccine received within a month before the trial starts.

Inclusion Criteria

I have a type of eye inflammation not caused by an infection.

I have tried and not responded to at least one standard rheumatoid arthritis medication or one anti-TNF drug.

I have inflammation or swelling in my eye confirmed by specific tests.

+2 more

Exclusion Criteria

I am likely to have cataract surgery during the trial.

Dose of concomitant immunosuppressive therapy at the baseline visit: Methotrexate (MTX) ˃ 25 mg per week, Cyclosporine ˃ 4 mg/kg per day, Mycophenolate mofetil ˃ 3 grams per day or an equivalent drug to mycophenolate mofetil (e.g. mycophenolic acid) at an equivalent dose approved by the medical monitor, Azathioprine ˃ 175 mg per day, Tacrolimus (oral formulation) > 8 mg per day, If entering the study on 1 concomitant immunosuppressive therapy, dose has been increased within the last 28 days prior to Baseline visit, Subject has received Retisert® (implant) within 3 years prior to the Baseline visit or that has had complications related to the device. Subject has had Retisert® (implant) removed within 90 days prior to the Baseline visit or has had complications related to the removal of the device, Subject has received intraocular or periocular corticosteroids within 30 days prior to Baseline visit, Subject with proliferative or severe non-proliferative diabetic retinopathy or clinically significant macular edema due to diabetic retinopathy, Subject with neovascular/wet age-related macular degeneration, Subject with abnormality of vitreo-retinal interface (i.e., vitreomacular traction, epiretinal membranes, etc.) with the potential for macular structural damage independent of the inflammatory process, deemed macular pathology is deemed by a retinal specialist to be a potential cofounder of patient's visual acuity reduction, Subject with severe vitreous haze that precludes visualization of the fundus at the baseline visit, Subject has received Ozurdex® (dexamethasone implant) within 6 months prior to the baseline visit, Subject has received intravitreal anti-VEGF therapy within 45 days of the Baseline visit for Lucentis® (ranibizumab) or Avastin® (bevacizumab) or within 60 days of the Baseline visit for anti-VEGF Trap (aflibercept), Subject has received intravitreal methotrexate within 90 days prior to the Baseline visit, Subject on systemic carbonic anhydrase inhibitor within 1 week prior to Screening visit, Subject with macular edema as the only sign of uveitis, Subject with a history of scleritis, Subject with intolerance to high-dose oral corticosteroids (equivalent of oral prednisone 1 mg/kg/day or 60 to 80 mg/day), Subject on cyclophosphamide within 30 days prior to the Baseline visit, Participation in other investigational drug or device clinical trials within 30 days prior to Day 0 or planning to participate in other investigational drug or device clinical trials within 180 days following 48 weeks after day 0. This includes both ocular and non-ocular clinical trials, Major surgery within 8 weeks prior to screening or planned major surgery within 6 months following randomization, Treatment with intravenous gamma globulin or plasmapheresis during the course of the trial, Immunization with a live/attenuated vaccine within 4 weeks prior to baseline, History of severe allergic or anaphylactic reactions to human, humanized monoclonal antibodies, Prior history of Crohn's Colitis or Ulcerative Colitis, Evidence of serious uncontrolled concomitant cardiovascular, nervous system, pulmonary (including obstructive pulmonary disease), renal, hepatic, endocrine (include uncontrolled diabetes mellitus) or gastrointestinal disease (including complicated diverticulitis, liver disease or peptic ulcer disease), Known active current or history of recurrent bacterial, viral, fungal, mycobacterial or other infections (including but not limited to tuberculosis and atypical mycobacterial disease, Hepatitis B and C, and herpes zoster, but excluding fungal infections of nail beds), Any major episode of infection requiring hospitalization or treatment with IV antibiotics within 4 weeks of screening or oral antibiotics within 2 weeks prior to screening, Active tuberculosis (TB) requiring treatment within the previous 3 years. Patients should be screened for latent TB and, if positive, treated following local practice guidelines prior to initiating trial. Patients treated for tuberculosis with no recurrence in 3 years are permitted, Primary or secondary immunodeficiency (history of or currently active), Evidence of active malignant disease, malignancies diagnosed within the previous 5 years (including hematological malignancies and solid tumors, except basal and squamous cell carcinoma of the skin or carcinoma in situ of the cervix uteri that has been excised and cured), Pregnant women or breast-feeding mothers, Patients with reproductive potential not willing to use an effective method of contraception, History of alcohol, drug, or chemical abuse within 1 year prior to screening, Serum creatinine > 1.6 mg/dL (141 μmol/L) in female patients and > 1.9 mg/dL (168 μmol/L) in male patients. Patients with serum creatinine values exceeding limits may be eligible for the study if their estimated glomerular filtration rates (GFR) are >30, Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 1.5 times upper limit of normal (ULN), Total Bilirubin > 1.5 ULN, Platelet count < 100 x 109/L (100,000/mm3), Hemoglobin < 85 g/L (8.5 g/dL; 5.3 mmol/L), White Blood Cells < 3.0 x 109/L (3000/mm3), Absolute Neutrophil Count < 2.0 x 109/L (2000/mm3), Absolute Lymphocyte Count < 0.5 x 109/L (500/mm3), Positive Hepatitis BsAg, or Hepatitis C antibody

I have or might have an eye infection causing inflammation.

+6 more

Participant Groups

The study is testing Ixekizumab Prefilled Syringe's effectiveness in treating refractory non-infectious uveitis compared to previous treatments that failed such as classic synthetic DMARDs and anti-TNF agents. It aims to see if this new treatment can manage the condition better.

2Treatment groups

Experimental Treatment

Group I: 4-week dosingExperimental Treatment1 Intervention

Subjects will self-administer subcutaneous injection of ixekizumab during the baseline week (Week 0) using a loading dose of 160 mg of subcutaneous ixekizumab (Taltz), followed by 80 mg of subcutaneous ixekizumab Q4 weeks for 24-weeks.

Group II: 2-week dosingExperimental Treatment1 Intervention

Ixekizumab is already approved in United States, European Union for the following indications:

🇺🇸 Approved in United States as Taltz for: