Dupilumab for Asthma
(VIA Trial)
Trial Summary
The trial does not specify if you need to stop taking your current medications, but it does exclude those who have used asthma biologic therapy, antiviral, immunosuppressive, or immune modulator therapies in the last 3 months. It also excludes those using inhaled nasal sprays.
Dupilumab has shown effectiveness in treating severe type-2 asthma by targeting specific pathways involved in inflammation, and its efficacy has been demonstrated in clinical trials. It is already used for other conditions like atopic dermatitis and chronic rhinitis, indicating its potential in managing asthma symptoms.
12345Dupilumab is generally considered safe for treating asthma, with studies showing minimal adverse events compared to a placebo. However, it may cause an increase in blood eosinophils (a type of white blood cell) and has been associated with some ocular (eye-related) adverse events, mostly in patients treated for atopic dermatitis.
12678Dupilumab is unique because it targets the IL-4 and IL-13 signaling pathways, which are involved in the inflammation process of asthma. This mechanism may offer an advantage over other biologics by being effective in both eosinophilic and non-eosinophilic severe asthma types, unlike some existing treatments.
12347Eligibility Criteria
Adults aged 18-40 with mild, well-controlled asthma may join this study. They must have a positive methacholine test, certain blood or breath markers of inflammation, and no recent use of strong immune therapies. Smokers or those with other lung diseases can't participate. Women who can get pregnant must use effective birth control.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either dupilumab or placebo and are subsequently exposed to the rhinovirus
Follow-up
Participants are monitored for safety and effectiveness after treatment, including changes in biomarkers and symptoms
Open-label extension (optional)
Participants may opt into continuation of treatment long-term
Participant Groups
Dupilumab is already approved in United States, European Union for the following indications:
- Atopic dermatitis
- Asthma
- Chronic rhinosinusitis with nasal polyps
- Eosinophilic esophagitis
- Atopic dermatitis
- Asthma
- Chronic rhinosinusitis with nasal polyps
- Eosinophilic esophagitis