Lifestyle Changes for Glaucoma

Recruiting in Palo Alto (17 mi)

Overseen byKaren Joos, MD,PhD

Age: Any Age

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Vanderbilt University Medical Center

No Placebo Group

Trial Summary

What is the purpose of this trial?Our experiments are designed to test the overall hypothesis that position-dependent or water-dependent intra-ocular pressure (IOP) spikes occur in humans, and that these challenge ocular homeostasis.

Eligibility Criteria

This trial is for individuals with open-angle glaucoma or normal-pressure glaucoma, as well as those with autonomic dysfunction. Healthy people can also join. Medical students, prisoners, and pregnant women are not eligible to participate.

Inclusion Criteria

You have a dysfunction in your autonomic nervous system.

Healthy individuals.

I have been diagnosed with normal-pressure glaucoma.

+1 more

Exclusion Criteria

Prisoners

You are pregnant.

Medical students cannot participate in the study.

Participant Groups

The study investigates how drinking water and changing body posture might affect the pressure inside the eye (IOP) in people with different types of glaucoma or autonomic dysfunction compared to healthy individuals.

4Treatment groups

Experimental Treatment

Active Control

Group I: Subjects with normal-pressure glaucomaExperimental Treatment2 Interventions

Subjects with open-angle glaucoma damage following a glaucoma specialist's examination without ever an intraocular pressure recording greater than 21 mm Hg. .1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

Group II: Subjects with autonomic dysfunctionExperimental Treatment2 Interventions

Subjects with known autonomic dysfunction diagnoses as defined by the General Clinical Research Center (GCRC) such as pure autonomic failure, Postural orthostatic tachycardia syndrome (POTS), and Multiple System Atrophy( MSA). 1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

Group III: Primary open-angle glaucoma subjectsExperimental Treatment2 Interventions

Subjects diagnosed with primary open-angle glaucoma following a glaucoma specialist's examination. 1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

Group IV: Normal subjectsActive Control2 Interventions

Subjects without evidence of glaucoma or autonomic dysfunction. ..1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.