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Lifestyle Changes for Glaucoma

N/A

Waitlist Available

Led By Karen Joos, MD,PhD

Research Sponsored by Vanderbilt University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with normal-pressure glaucoma

Patients with open-angle glaucoma

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within 1 day

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing if increased pressure in the eye affects its stability.

Who is the study for?

This trial is for individuals with open-angle glaucoma or normal-pressure glaucoma, as well as those with autonomic dysfunction. Healthy people can also join. Medical students, prisoners, and pregnant women are not eligible to participate.

What is being tested?

The study investigates how drinking water and changing body posture might affect the pressure inside the eye (IOP) in people with different types of glaucoma or autonomic dysfunction compared to healthy individuals.

What are the potential side effects?

Since this trial involves non-invasive interventions like drinking water and postural changes, side effects may be minimal but could include discomfort from eye pressure measurements or dizziness upon standing.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with normal-pressure glaucoma.

Select...

I have open-angle glaucoma.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within 1 day

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within 1 day

This trial's timeline: 3 weeks for screening, Varies for treatment, and within 1 day for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Intraocular Pressure

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups

Experimental Treatment

Active Control

Group I: Subjects with normal-pressure glaucomaExperimental Treatment2 Interventions

Subjects with open-angle glaucoma damage following a glaucoma specialist's examination without ever an intraocular pressure recording greater than 21 mm Hg. .1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

Group II: Subjects with autonomic dysfunctionExperimental Treatment2 Interventions

Subjects with known autonomic dysfunction diagnoses as defined by the General Clinical Research Center (GCRC) such as pure autonomic failure, Postural orthostatic tachycardia syndrome (POTS), and Multiple System Atrophy( MSA). 1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

Group III: Primary open-angle glaucoma subjectsExperimental Treatment2 Interventions

Subjects diagnosed with primary open-angle glaucoma following a glaucoma specialist's examination. 1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

Group IV: Normal subjectsActive Control2 Interventions

Subjects without evidence of glaucoma or autonomic dysfunction. ..1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

0 / 2Eligibility criteria met