Physical Activity for Alzheimer's Disease
(RAATE-MCI Trial)
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Pennington Biomedical Research Center
Disqualifiers: Dementia, Uncontrolled hypertension, Recent heart surgery, others
No Placebo Group
Trial Summary
What is the purpose of this trial?The RAATE-MCI proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group. RAATE-MCI is a 52-week randomized controlled trial. 144 African American adults aged 60 and older will be recruited.
Do I need to stop my current medications to join the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Physical activity program for Alzheimer's Disease?
Research shows that exercise programs can help improve daily living activities, physical performance, and reduce depression in people with Alzheimer's disease. These programs can also enhance functional capacity and mobility, making everyday tasks easier for those affected.
12345Is physical activity safe for people with Alzheimer's disease?
Research indicates that exercise programs, including home-based ones, are generally safe for people with Alzheimer's disease, with studies focusing on their feasibility and safety.
12678How is the physical activity program treatment for Alzheimer's disease different from other treatments?
The physical activity program for Alzheimer's disease is unique because it focuses on improving patients' functional abilities and independence through regular exercise, which can be done at home or in care settings, making it more accessible and easier for caregivers to manage compared to traditional medical treatments.
124910Eligibility Criteria
The RAATE-MCI trial is for African American adults aged 60 or older who self-identify as such, are willing to be randomly assigned to groups, can attend sessions and travel within the study area for a year. They must be physically able to exercise but not currently active, have mild cognitive impairment without severe dementia, and agree to data use after the study.Inclusion Criteria
Physically capable of exercise
Free of conditions that would make regular exercise unsafe as deemed by the medical investigator
Willing to accept randomization
+9 more
Exclusion Criteria
I am not willing to sign consent or be randomly assigned to a study group.
I am currently in a heart and lung rehab program.
My diabetes is not under control.
+11 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants are assigned to either a physical activity intervention or a successful aging group for 52 weeks
52 weeks
Regular sessions at Pennington Biomedical or local community facilities
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Participant Groups
This trial tests if physical activity affects Alzheimer's risk factors in older African Americans. Participants will either join a physical activity program or an active control group for one year. The goal is to see how exercise influences cognitive health compared with usual activities.
2Treatment groups
Experimental Treatment
Group I: Successful AgingExperimental Treatment1 Intervention
Low intensity activity program and a healthy aging educational component
Group II: Physical ActivityExperimental Treatment1 Intervention
150 minutes of physical activity weekly
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Pennington Biomedical ResearchBaton Rouge, LA
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Who Is Running the Clinical Trial?
Pennington Biomedical Research CenterLead Sponsor
National Institute on Aging (NIA)Collaborator
References
Evaluation of a home-based exercise program in the treatment of Alzheimer's disease: the Maximizing Independence in Dementia (MIND) study. [2022]To determine the feasibility and efficacy of a home-based exercise intervention program to improve the functional performance of patients with Alzheimer's Disease (AD).
Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial. [2022]To investigate the effectiveness of an exercise program in improving ability to perform activities of daily living (ADLs), physical performance, and nutritional status and decreasing behavioral disturbance and depression in patients with Alzheimer's disease (AD).
Effectiveness of physical exercise at improving functional capacity in older adults living with Alzheimer's disease: a systematic review of randomized controlled trials. [2023]To investigate the effects of physical exercise at improving functional capacity in older adults living with Alzheimer's disease (AD).
A randomized controlled trial of an activity specific exercise program for individuals with Alzheimer disease in long-term care settings. [2021]To determine whether an activity specific exercise program could improve ability to perform basic mobility activities in long-term care residents with Alzheimer disease (AD).
Benefits of physical exercise for older adults with Alzheimer's disease. [2008]The physical and mental benefits of exercise are widely known but seldom available to persons suffering from Alzheimer's disease (AD). This article presents information on the potential benefits of physical exercise for people with AD, discussing some of the metabolic and neuropathological changes regarded as underlying causes of AD, as well as some of the psychological and organic abnormalities that can be modified through exercise. The extent to which physical exercise programs can play a role in the treatment of AD is addressed in the second part of the article, describing the most relevant clinical studies in this field. Finally, the article provides information about how to prescribe physical exercise for AD patients, mainly by giving examples of structured physical programs designed for older adults with dementia.
What are older Latinos told about physical activity and cognition? A content analysis of a top-circulating magazine. [2021]Physical activity (PA) may reduce risk of developing Alzheimer's disease (AD). The objectives of this study were to: (a) Compare the content of English and Spanish PA-focused articles in American Association of Retired Persons (AARP) magazines; and (b) Determine whether these articles discuss PA as a potential correlate of AD.
An integrative review of exercise interventions among community-dwelling adults with Alzheimer's disease. [2020]To synthesise the current research on exercise interventions and health-related outcomes among community-dwelling adults with Alzheimer's disease (AD).
Feasibility, safety and preliminary evidence of the effectiveness of a home-based exercise programme for older people with Alzheimer's disease: a pilot randomized controlled trial. [2022]To evaluate the feasibility and safety of a home-based exercise programme for people with Alzheimer's disease, and to provide preliminary evidence of programme effectiveness in improving balance and mobility and reducing falls risk.
Feasibility [corrected] of regular physical exercise for patients with moderate to severe Alzheimer disease. [2019]Physical activity delays loss of autonomy in the elderly. In patients with Alzheimer disease (AD), physical activity could be a useful strategy in therapeutic management by delaying loss of functional independence and the usual complications of the disease.
Home-based multimodal exercise program in older people with Alzheimer disease: Randomized controlled trial protocol. [2021]At-home physical exercise may be an important intervention strategy for older people with Alzheimer disease (AD) due to the greater adherence and ease for the caregivers.