Carbon Dioxide Levels for Anesthesia in Children

N/A

Recruiting

Led By Christopher A Chin, MBBS, FRCA, FRCP, MA

Research Sponsored by University of British Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Controlled ventilation via endotracheal tube

American Society of Anesthesiologists (ASA) physical status I and II

Timeline

Screening 3 weeks

Treatment Varies

Follow Up continually assessed throughout the general anesthetic, approximately 1.5-2 hours

Awards & highlights

No Placebo-Only Group

Summary

This trial will investigate how different levels of carbon dioxide during intravenous anesthesia affect the sedation or sleepiness levels in children. The study aims to see if adjusting CO2 levels can reduce the amount of

Who is the study for?

This trial is for children aged 3-11 years who need anesthesia for non-painful or minimally painful procedures, like certain ear surgeries or dental work with local anesthetics. They should be generally healthy (ASA status I and II) and the procedure should last at least 90 minutes to allow time for testing.

What is being tested?

The study tests how different CO2 levels during anesthesia affect sleepiness in children, using a BIS monitor that measures brain activity. It compares normal CO2 levels (40 mmHg), high normal levels (50 mmHg), and low normal levels (30 mmHg) to see if they can reduce the amount of anesthetic needed.

What are the potential side effects?

While not explicitly stated, potential side effects may include respiratory changes due to varying CO2 levels. High CO2 might cause deeper sedation while low CO2 could lead to lighter anesthesia than intended.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am on a breathing machine through a tube in my windpipe.

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I am in good or mild systemic disease condition according to ASA standards.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ continually assessed throughout the general anesthetic, approximately 1.5-2 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~continually assessed throughout the general anesthetic, approximately 1.5-2 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and continually assessed throughout the general anesthetic, approximately 1.5-2 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

To determine the effect of end-tidal carbon dioxide concentration (EtCO2) on the depth of anesthesia in children, as measured by BIS.

Secondary study objectives

Patient movement as detected clinically by the surgical or anesthetic team.

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.